Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020
Dengue virus (DENV) serotype-2 was detected in the South Pacific region in 2014 for the first time in 15 years. In 2016–2020, DENV-2 re-emerged in French Polynesia, Vanuatu, Wallis and Futuna, and New Caledonia, co-circulating with and later replacing DENV-1. In this context, epidemiological and mol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/10/1081 |
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| author | Catherine Inizan Olivia O’Connor George Worwor Talica Cabemaiwai Jean-Claude Grignon Dominique Girault Marine Minier Matthieu Prot Valentine Ballan George Junior Pakoa Jean-Paul Grangeon Philippe Guyant Christelle Lepers Daniel Faktaufon Aalisha Sahukhan Onofre Edwin Merilles Ann-Claire Gourinat Etienne Simon-Lorière Myrielle Dupont-Rouzeyrol |
| author_facet | Catherine Inizan Olivia O’Connor George Worwor Talica Cabemaiwai Jean-Claude Grignon Dominique Girault Marine Minier Matthieu Prot Valentine Ballan George Junior Pakoa Jean-Paul Grangeon Philippe Guyant Christelle Lepers Daniel Faktaufon Aalisha Sahukhan Onofre Edwin Merilles Ann-Claire Gourinat Etienne Simon-Lorière Myrielle Dupont-Rouzeyrol |
| author_sort | Catherine Inizan |
| collection | DOAJ |
| description | Dengue virus (DENV) serotype-2 was detected in the South Pacific region in 2014 for the first time in 15 years. In 2016–2020, DENV-2 re-emerged in French Polynesia, Vanuatu, Wallis and Futuna, and New Caledonia, co-circulating with and later replacing DENV-1. In this context, epidemiological and molecular evolution data are paramount to decipher the diffusion route of this DENV-2 in the South Pacific region. In the current work, the <i>E</i> gene from 23 DENV-2 serum samples collected in Vanuatu, Fiji, Wallis and Futuna, and New Caledonia was sequenced. Both maximum likelihood and Bayesian phylogenetic analyses were performed. While all DENV-2 strains sequenced belong to the Cosmopolitan genotype, phylogenetic analysis suggests at least three different DENV-2 introductions in the South Pacific between 2017 and 2020. Strains retrieved in these Pacific Islands Countries and Territories (PICTs) in 2017–2020 are phylogenetically related, with strong phylogenetic links between strains retrieved from French PICTs. These phylogenetic data substantiate epidemiological data of the DENV-2 diffusion pattern between these countries. |
| first_indexed | 2024-03-10T16:02:44Z |
| format | Article |
| id | doaj.art-727f69a2b8164276901831dfa575557e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T16:02:44Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-727f69a2b8164276901831dfa575557e2023-11-20T15:09:23ZengMDPI AGViruses1999-49152020-09-011210108110.3390/v12101081Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020Catherine Inizan0Olivia O’Connor1George Worwor2Talica Cabemaiwai3Jean-Claude Grignon4Dominique Girault5Marine Minier6Matthieu Prot7Valentine Ballan8George Junior Pakoa9Jean-Paul Grangeon10Philippe Guyant11Christelle Lepers12Daniel Faktaufon13Aalisha Sahukhan14Onofre Edwin Merilles15Ann-Claire Gourinat16Etienne Simon-Lorière17Myrielle Dupont-Rouzeyrol18Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New CaledoniaInstitut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New CaledoniaSurveillance, Emergency and Research Unit, Ministry of Health, Port Vila, VanuatuNational Public Health Laboratory, Fiji Centre For Communicable Disease Control, Suva, FijiLaboratoire de Biologie Médicale, Hôpital de Sia, Mata’Utu 98600, Wallis et FutunaInstitut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New CaledoniaInstitut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New CaledoniaEvolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, 75015 Paris, FranceInstitut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New CaledoniaSurveillance, Emergency and Research Unit, Ministry of Health, Port Vila, VanuatuNew Caledonia Health Authorities (Direction des Affaires Sanitaires et Sociales-Nouvelle-Calédonie, DASS-NC), Noumea 98800, New CaledoniaWHO Country Liaison Office, Port Vila, VanuatuPacific Community (SPC), Noumea 98800, New CaledoniaNational Public Health Laboratory, Fiji Centre For Communicable Disease Control, Suva, FijiNational Public Health Laboratory, Fiji Centre For Communicable Disease Control, Suva, FijiPacific Community (SPC), Noumea 98800, New CaledoniaCentre Hospitalier Territorial, Microbiology Laboratory, Dumbea-sur-Mer, Dumbea 98835, New CaledoniaEvolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, 75015 Paris, FranceInstitut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New CaledoniaDengue virus (DENV) serotype-2 was detected in the South Pacific region in 2014 for the first time in 15 years. In 2016–2020, DENV-2 re-emerged in French Polynesia, Vanuatu, Wallis and Futuna, and New Caledonia, co-circulating with and later replacing DENV-1. In this context, epidemiological and molecular evolution data are paramount to decipher the diffusion route of this DENV-2 in the South Pacific region. In the current work, the <i>E</i> gene from 23 DENV-2 serum samples collected in Vanuatu, Fiji, Wallis and Futuna, and New Caledonia was sequenced. Both maximum likelihood and Bayesian phylogenetic analyses were performed. While all DENV-2 strains sequenced belong to the Cosmopolitan genotype, phylogenetic analysis suggests at least three different DENV-2 introductions in the South Pacific between 2017 and 2020. Strains retrieved in these Pacific Islands Countries and Territories (PICTs) in 2017–2020 are phylogenetically related, with strong phylogenetic links between strains retrieved from French PICTs. These phylogenetic data substantiate epidemiological data of the DENV-2 diffusion pattern between these countries.https://www.mdpi.com/1999-4915/12/10/1081denguephylogenymolecular evolutionPacific |
| spellingShingle | Catherine Inizan Olivia O’Connor George Worwor Talica Cabemaiwai Jean-Claude Grignon Dominique Girault Marine Minier Matthieu Prot Valentine Ballan George Junior Pakoa Jean-Paul Grangeon Philippe Guyant Christelle Lepers Daniel Faktaufon Aalisha Sahukhan Onofre Edwin Merilles Ann-Claire Gourinat Etienne Simon-Lorière Myrielle Dupont-Rouzeyrol Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020 Viruses dengue phylogeny molecular evolution Pacific |
| title | Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020 |
| title_full | Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020 |
| title_fullStr | Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020 |
| title_full_unstemmed | Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020 |
| title_short | Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020 |
| title_sort | molecular characterization of dengue type 2 outbreak in pacific islands countries and territories 2017 2020 |
| topic | dengue phylogeny molecular evolution Pacific |
| url | https://www.mdpi.com/1999-4915/12/10/1081 |
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