Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus—A Case Report and Literature Review
In this article, we report on a rare case of acute respiratory distress syndrome (ARDS) caused by the Puumala orthohantavirus (PUUV), which is typically associated with hemorrhagic fever with renal syndrome (HFRS). This is the first documented case of PUUV-associated ARDS in Southeast Europe. The di...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/12/2963 |
| _version_ | 1797379986569560064 |
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| author | Marija Santini Jelena Ljubić Nikola Šoštar Tatjana Vilibić-Čavlek Maja Bogdanić Samo Zakotnik Tatjana Avšič-Županc Miša Korva Ivan Christian Kurolt Leona Radmanić Petra Šimičić Juraj Krznarić Branimir Gjurašin Marko Kutleša Klaudija Višković Nataša Cetinić Balent Renata Žunec Ivana Margeta Marić Ana Ribarović Snjezana Židovec-Lepej |
| author_facet | Marija Santini Jelena Ljubić Nikola Šoštar Tatjana Vilibić-Čavlek Maja Bogdanić Samo Zakotnik Tatjana Avšič-Županc Miša Korva Ivan Christian Kurolt Leona Radmanić Petra Šimičić Juraj Krznarić Branimir Gjurašin Marko Kutleša Klaudija Višković Nataša Cetinić Balent Renata Žunec Ivana Margeta Marić Ana Ribarović Snjezana Židovec-Lepej |
| author_sort | Marija Santini |
| collection | DOAJ |
| description | In this article, we report on a rare case of acute respiratory distress syndrome (ARDS) caused by the Puumala orthohantavirus (PUUV), which is typically associated with hemorrhagic fever with renal syndrome (HFRS). This is the first documented case of PUUV-associated ARDS in Southeast Europe. The diagnosis was confirmed by serum RT-PCR and serology and corroborated by phylogenetic analysis and chemokine profiling. The patient was a 23-year-old male from Zagreb, Croatia, who had recently traveled throughout Europe. He presented with fever, headache, abdominal pain, and sudden onset of ARDS. Treatment involved high-flow nasal cannula oxygen therapy and glucocorticoids, which resulted in a full recovery. A systematic literature review identified 10 cases of hantavirus pulmonary syndrome (HPS) caused by PUUV in various European countries and Turkey between 2002 and 2023. The median age of patients was 53 years (range 24–73), and six of the patients were male. Most patients were treated in intensive care units, but none received antiviral therapy targeting PUUV. Eight patients survived hospitalization. The presented case highlights the importance of considering HPS in the differential diagnosis of ARDS, even in areas where HFRS is the dominant form of hantavirus infection. |
| first_indexed | 2024-03-08T20:30:57Z |
| format | Article |
| id | doaj.art-7280052fa13c47d3bf89a03522ab17ec |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-08T20:30:57Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-7280052fa13c47d3bf89a03522ab17ec2023-12-22T14:26:14ZengMDPI AGMicroorganisms2076-26072023-12-011112296310.3390/microorganisms11122963Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus—A Case Report and Literature ReviewMarija Santini0Jelena Ljubić1Nikola Šoštar2Tatjana Vilibić-Čavlek3Maja Bogdanić4Samo Zakotnik5Tatjana Avšič-Županc6Miša Korva7Ivan Christian Kurolt8Leona Radmanić9Petra Šimičić10Juraj Krznarić11Branimir Gjurašin12Marko Kutleša13Klaudija Višković14Nataša Cetinić Balent15Renata Žunec16Ivana Margeta Marić17Ana Ribarović18Snjezana Židovec-Lepej19Department for Infections in Immunocompromised Patients, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, CroatiaInfectious Diseases Department, County Hospital Čakovec, 40000 Čakovec, CroatiaEmergency Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, CroatiaSchool of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Virology, Croatian Institute of Public Health, 10000 Zagreb, CroatiaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaResearch Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, CroatiaDepartment for Molecular Diagnostics and Flow Cytometry, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, CroatiaDepartment for Molecular Diagnostics and Flow Cytometry, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, CroatiaSchool of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Intensive Care Medicine and Neuroinfectology, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, CroatiaSchool of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Radiology and Ultrasound, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, CroatiaDepartment of Clinical Microbiology, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, CroatiaTissue Typing Laboratory, University Hospital Zagreb, 10000 Zagreb, CroatiaCounty Hospital “Dr. Josip Benčević”, 35000 Slavonski Brod, CroatiaCounty Hospital Zadar, 23000 Zadar, CroatiaDepartment for Molecular Diagnostics and Flow Cytometry, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, CroatiaIn this article, we report on a rare case of acute respiratory distress syndrome (ARDS) caused by the Puumala orthohantavirus (PUUV), which is typically associated with hemorrhagic fever with renal syndrome (HFRS). This is the first documented case of PUUV-associated ARDS in Southeast Europe. The diagnosis was confirmed by serum RT-PCR and serology and corroborated by phylogenetic analysis and chemokine profiling. The patient was a 23-year-old male from Zagreb, Croatia, who had recently traveled throughout Europe. He presented with fever, headache, abdominal pain, and sudden onset of ARDS. Treatment involved high-flow nasal cannula oxygen therapy and glucocorticoids, which resulted in a full recovery. A systematic literature review identified 10 cases of hantavirus pulmonary syndrome (HPS) caused by PUUV in various European countries and Turkey between 2002 and 2023. The median age of patients was 53 years (range 24–73), and six of the patients were male. Most patients were treated in intensive care units, but none received antiviral therapy targeting PUUV. Eight patients survived hospitalization. The presented case highlights the importance of considering HPS in the differential diagnosis of ARDS, even in areas where HFRS is the dominant form of hantavirus infection.https://www.mdpi.com/2076-2607/11/12/2963hantavirushantavirus pulmonary syndromeacute respiratory distress syndromePuumala orthohantavirusimmunomodulatory therapychemokine profile |
| spellingShingle | Marija Santini Jelena Ljubić Nikola Šoštar Tatjana Vilibić-Čavlek Maja Bogdanić Samo Zakotnik Tatjana Avšič-Županc Miša Korva Ivan Christian Kurolt Leona Radmanić Petra Šimičić Juraj Krznarić Branimir Gjurašin Marko Kutleša Klaudija Višković Nataša Cetinić Balent Renata Žunec Ivana Margeta Marić Ana Ribarović Snjezana Židovec-Lepej Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus—A Case Report and Literature Review Microorganisms hantavirus hantavirus pulmonary syndrome acute respiratory distress syndrome Puumala orthohantavirus immunomodulatory therapy chemokine profile |
| title | Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus—A Case Report and Literature Review |
| title_full | Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus—A Case Report and Literature Review |
| title_fullStr | Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus—A Case Report and Literature Review |
| title_full_unstemmed | Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus—A Case Report and Literature Review |
| title_short | Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus—A Case Report and Literature Review |
| title_sort | hantavirus pulmonary syndrome caused by puumala orthohantavirus a case report and literature review |
| topic | hantavirus hantavirus pulmonary syndrome acute respiratory distress syndrome Puumala orthohantavirus immunomodulatory therapy chemokine profile |
| url | https://www.mdpi.com/2076-2607/11/12/2963 |
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