Glucose tolerance test with a single abnormal value as a predictor of type 2 diabetes mellitus: a multicenter retrospective study
Abstract Clinical implication of a single abnormal value (SAV) in the 100 g oral glucose tolerance test during pregnancy has not been established. We aimed to evaluate the risk of postpartum type 2 diabetes mellitus (T2DM) and investigate adverse pregnancy outcomes in women with SAV, using a retrosp...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-57535-8 |
| _version_ | 1827310210953248768 |
|---|---|
| author | Seon Ui Lee Subeen Hong Sae Kyung Choi Su Mi Kim Jae Eun Shin Ki Cheol Kil Yeon Hee Kim Jeong Ha Wie Yun Sung Jo Hyun Sun Ko |
| author_facet | Seon Ui Lee Subeen Hong Sae Kyung Choi Su Mi Kim Jae Eun Shin Ki Cheol Kil Yeon Hee Kim Jeong Ha Wie Yun Sung Jo Hyun Sun Ko |
| author_sort | Seon Ui Lee |
| collection | DOAJ |
| description | Abstract Clinical implication of a single abnormal value (SAV) in the 100 g oral glucose tolerance test during pregnancy has not been established. We aimed to evaluate the risk of postpartum type 2 diabetes mellitus (T2DM) and investigate adverse pregnancy outcomes in women with SAV, using a retrospective database, from seven medical centers of Korea. Based on the Carpenter-Coustan criteria using two-step approach, pregnancy and postpartum outcomes were compared, among normoglycemic, SAV, and gestational diabetes mellitus (GDM) groups. Among 9353 women, 342 (3.66%) and 418(4.47%) women were included in SAV and GDM groups, respectively. SAV and GDM groups showed significantly higher rates of postpartum T2DM than normoglycemic group (7.60%, 14.83%, and 1.82%, respectively, p < 0.001). And SAV group showed significantly higher rates of pregnancy associated hypertension, preterm birth, and neonatal hypoglycemia and sepsis, compared to normoglycemic group (neonatal sepsis, p = 0.008; the others, p < 0.001). In multivariate analysis, postpartum T2DM was associated with SAV, GDM (with/without insulin), nulliparity, pre-pregnancy BMI, chronic hypertension, hyperlipidemia, and DM family history. A scoring model to predict postpartum T2DM within 5 years, achieved an area under the curve of 0.74. This study demonstrated that not only GDM, but also SAV is a significant risk factor for postpartum T2DM. |
| first_indexed | 2024-04-24T19:56:02Z |
| format | Article |
| id | doaj.art-7281a7e0a3d241199209e9bd03bd0380 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T19:56:02Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7281a7e0a3d241199209e9bd03bd03802024-03-24T12:19:12ZengNature PortfolioScientific Reports2045-23222024-03-0114111310.1038/s41598-024-57535-8Glucose tolerance test with a single abnormal value as a predictor of type 2 diabetes mellitus: a multicenter retrospective studySeon Ui Lee0Subeen Hong1Sae Kyung Choi2Su Mi Kim3Jae Eun Shin4Ki Cheol Kil5Yeon Hee Kim6Jeong Ha Wie7Yun Sung Jo8Hyun Sun Ko9Department of Obstetrics and Gynecology, College of Medicine, Incheon St. Mary’s Hospital, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Incheon St. Mary’s Hospital, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, St. Vincent’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Obstetrics and Gynecology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaAbstract Clinical implication of a single abnormal value (SAV) in the 100 g oral glucose tolerance test during pregnancy has not been established. We aimed to evaluate the risk of postpartum type 2 diabetes mellitus (T2DM) and investigate adverse pregnancy outcomes in women with SAV, using a retrospective database, from seven medical centers of Korea. Based on the Carpenter-Coustan criteria using two-step approach, pregnancy and postpartum outcomes were compared, among normoglycemic, SAV, and gestational diabetes mellitus (GDM) groups. Among 9353 women, 342 (3.66%) and 418(4.47%) women were included in SAV and GDM groups, respectively. SAV and GDM groups showed significantly higher rates of postpartum T2DM than normoglycemic group (7.60%, 14.83%, and 1.82%, respectively, p < 0.001). And SAV group showed significantly higher rates of pregnancy associated hypertension, preterm birth, and neonatal hypoglycemia and sepsis, compared to normoglycemic group (neonatal sepsis, p = 0.008; the others, p < 0.001). In multivariate analysis, postpartum T2DM was associated with SAV, GDM (with/without insulin), nulliparity, pre-pregnancy BMI, chronic hypertension, hyperlipidemia, and DM family history. A scoring model to predict postpartum T2DM within 5 years, achieved an area under the curve of 0.74. This study demonstrated that not only GDM, but also SAV is a significant risk factor for postpartum T2DM.https://doi.org/10.1038/s41598-024-57535-8 |
| spellingShingle | Seon Ui Lee Subeen Hong Sae Kyung Choi Su Mi Kim Jae Eun Shin Ki Cheol Kil Yeon Hee Kim Jeong Ha Wie Yun Sung Jo Hyun Sun Ko Glucose tolerance test with a single abnormal value as a predictor of type 2 diabetes mellitus: a multicenter retrospective study Scientific Reports |
| title | Glucose tolerance test with a single abnormal value as a predictor of type 2 diabetes mellitus: a multicenter retrospective study |
| title_full | Glucose tolerance test with a single abnormal value as a predictor of type 2 diabetes mellitus: a multicenter retrospective study |
| title_fullStr | Glucose tolerance test with a single abnormal value as a predictor of type 2 diabetes mellitus: a multicenter retrospective study |
| title_full_unstemmed | Glucose tolerance test with a single abnormal value as a predictor of type 2 diabetes mellitus: a multicenter retrospective study |
| title_short | Glucose tolerance test with a single abnormal value as a predictor of type 2 diabetes mellitus: a multicenter retrospective study |
| title_sort | glucose tolerance test with a single abnormal value as a predictor of type 2 diabetes mellitus a multicenter retrospective study |
| url | https://doi.org/10.1038/s41598-024-57535-8 |
| work_keys_str_mv | AT seonuilee glucosetolerancetestwithasingleabnormalvalueasapredictoroftype2diabetesmellitusamulticenterretrospectivestudy AT subeenhong glucosetolerancetestwithasingleabnormalvalueasapredictoroftype2diabetesmellitusamulticenterretrospectivestudy AT saekyungchoi glucosetolerancetestwithasingleabnormalvalueasapredictoroftype2diabetesmellitusamulticenterretrospectivestudy AT sumikim glucosetolerancetestwithasingleabnormalvalueasapredictoroftype2diabetesmellitusamulticenterretrospectivestudy AT jaeeunshin glucosetolerancetestwithasingleabnormalvalueasapredictoroftype2diabetesmellitusamulticenterretrospectivestudy AT kicheolkil glucosetolerancetestwithasingleabnormalvalueasapredictoroftype2diabetesmellitusamulticenterretrospectivestudy AT yeonheekim glucosetolerancetestwithasingleabnormalvalueasapredictoroftype2diabetesmellitusamulticenterretrospectivestudy AT jeonghawie glucosetolerancetestwithasingleabnormalvalueasapredictoroftype2diabetesmellitusamulticenterretrospectivestudy AT yunsungjo glucosetolerancetestwithasingleabnormalvalueasapredictoroftype2diabetesmellitusamulticenterretrospectivestudy AT hyunsunko glucosetolerancetestwithasingleabnormalvalueasapredictoroftype2diabetesmellitusamulticenterretrospectivestudy |