A digital health weight-loss intervention in severe obesity
Introduction Severe obesity is a growing epidemic that causes significant morbidity and mortality, and is particularly difficult to reverse. Efficacious and cost-effective interventions are needed to combat this epidemic. This study hypothesized that obese people (body mass index (BMI) ≥35 kg/m 2 )...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-03-01
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| Series: | Digital Health |
| Online Access: | https://doi.org/10.1177/2055207620910279 |
| _version_ | 1828867606356951040 |
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| author | Conor Senecal Maria Collazo-Clavell Beth R Larrabee Mariza de Andrade Weihua Lin Bing Chen Lilach O. Lerman Amir Lerman Francisco Lopez-Jimenez |
| author_facet | Conor Senecal Maria Collazo-Clavell Beth R Larrabee Mariza de Andrade Weihua Lin Bing Chen Lilach O. Lerman Amir Lerman Francisco Lopez-Jimenez |
| author_sort | Conor Senecal |
| collection | DOAJ |
| description | Introduction Severe obesity is a growing epidemic that causes significant morbidity and mortality, and is particularly difficult to reverse. Efficacious and cost-effective interventions are needed to combat this epidemic. This study hypothesized that obese people (body mass index (BMI) ≥35 kg/m 2 ) using a remote weight-loss program combining a mobile application, wireless scales, and low-calorie meal replacement would experience clinically significant weight loss. Methods This study was a retrospective observational analysis of 8275 individuals with a baseline BMI ≥35 kg/m 2 who used a remote weight-loss program combining mobile applications, frequent self-weighing, and calorie restriction via meal replacement for a minimum of 35 days. Weight changes were evaluated at multiple intervals (42, 60, 90, and 120 days), and weight loss was evaluated for all and for pre-specified subgroups based on demographic features and frequency of self-weighing. Results Mean weight loss at 42 days ( N = 6781) was 8.1 kg (margin of error (MOE) = 0.126 kg) with 73.6% of users experiencing >5% total body weight loss. Both men (9.1 kg; MOE = 0.172 kg; 7.9% from baseline) and women (7.1 kg; MOE = 0.179 kg; 7.2% from baseline) experienced significant weight loss. At the 120-day interval ( N = 2914), mean weight loss was 14 kg (MOE = 0.340 kg), 13% total body weight loss from baseline, and 82.3% of participants had lost >5% of their initial body weight. The decrease in body-fat percent correlated well with weight loss ( R = 0.92; p < 0.001). Conclusions In a large cohort of individuals with class II or III obesity, a remote weight-loss program combining mobile applications, daily self-weighing, and calorie restriction via meal replacement resulted in dramatic weight loss among subjects who were active users when evaluated through a retrospective observational analysis. |
| first_indexed | 2024-12-13T05:14:03Z |
| format | Article |
| id | doaj.art-728504bd62894c438b2c2f10aca84e2d |
| institution | Directory Open Access Journal |
| issn | 2055-2076 |
| language | English |
| last_indexed | 2024-12-13T05:14:03Z |
| publishDate | 2020-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Digital Health |
| spelling | doaj.art-728504bd62894c438b2c2f10aca84e2d2022-12-21T23:58:28ZengSAGE PublishingDigital Health2055-20762020-03-01610.1177/2055207620910279A digital health weight-loss intervention in severe obesityConor Senecal0Maria Collazo-Clavell1Beth R Larrabee2Mariza de Andrade3Weihua Lin4Bing Chen5Lilach O. Lerman6Amir Lerman7Francisco Lopez-Jimenez8 Department of Cardiovascular Medicine, Mayo Clinic, USA Division of Endocrinology, Department of Medicine, Mayo Clinic, USA Division of Biostatistics, Mayo Clinic College of Medicine, USA Division of Biostatistics, Mayo Clinic College of Medicine, USA Hangzhou MetaWell Technology Co., PR China Hangzhou MetaWell Technology Co., PR China Hangzhou MetaWell Technology Co., PR China Department of Cardiovascular Medicine, Mayo Clinic, USA Department of Cardiovascular Medicine, Mayo Clinic, USAIntroduction Severe obesity is a growing epidemic that causes significant morbidity and mortality, and is particularly difficult to reverse. Efficacious and cost-effective interventions are needed to combat this epidemic. This study hypothesized that obese people (body mass index (BMI) ≥35 kg/m 2 ) using a remote weight-loss program combining a mobile application, wireless scales, and low-calorie meal replacement would experience clinically significant weight loss. Methods This study was a retrospective observational analysis of 8275 individuals with a baseline BMI ≥35 kg/m 2 who used a remote weight-loss program combining mobile applications, frequent self-weighing, and calorie restriction via meal replacement for a minimum of 35 days. Weight changes were evaluated at multiple intervals (42, 60, 90, and 120 days), and weight loss was evaluated for all and for pre-specified subgroups based on demographic features and frequency of self-weighing. Results Mean weight loss at 42 days ( N = 6781) was 8.1 kg (margin of error (MOE) = 0.126 kg) with 73.6% of users experiencing >5% total body weight loss. Both men (9.1 kg; MOE = 0.172 kg; 7.9% from baseline) and women (7.1 kg; MOE = 0.179 kg; 7.2% from baseline) experienced significant weight loss. At the 120-day interval ( N = 2914), mean weight loss was 14 kg (MOE = 0.340 kg), 13% total body weight loss from baseline, and 82.3% of participants had lost >5% of their initial body weight. The decrease in body-fat percent correlated well with weight loss ( R = 0.92; p < 0.001). Conclusions In a large cohort of individuals with class II or III obesity, a remote weight-loss program combining mobile applications, daily self-weighing, and calorie restriction via meal replacement resulted in dramatic weight loss among subjects who were active users when evaluated through a retrospective observational analysis.https://doi.org/10.1177/2055207620910279 |
| spellingShingle | Conor Senecal Maria Collazo-Clavell Beth R Larrabee Mariza de Andrade Weihua Lin Bing Chen Lilach O. Lerman Amir Lerman Francisco Lopez-Jimenez A digital health weight-loss intervention in severe obesity Digital Health |
| title | A digital health weight-loss intervention in severe obesity |
| title_full | A digital health weight-loss intervention in severe obesity |
| title_fullStr | A digital health weight-loss intervention in severe obesity |
| title_full_unstemmed | A digital health weight-loss intervention in severe obesity |
| title_short | A digital health weight-loss intervention in severe obesity |
| title_sort | digital health weight loss intervention in severe obesity |
| url | https://doi.org/10.1177/2055207620910279 |
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