The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer
Purpose: Firstly, we aimed to investigate the correlation among dynamic contrasted magnetic resonance (MR) images, diffusion-weighted MR images, and apparent diffusion coefficent (ADC) values in patients with prostate cancer. Secondly, we aimed to investigate the roles of these variables on clinical...
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| Format: | Article |
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PAGEPress Publications
2017-12-01
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| Series: | Archivio Italiano di Urologia e Andrologia |
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| Online Access: | http://www.pagepressjournals.org/index.php/aiua/article/view/6924 |
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| author | Bedriye Koyuncu Sokmen Dogukan Sokmen Nese Ucar Huseyin Ozkurt Abdulmuttalip Simsek |
| author_facet | Bedriye Koyuncu Sokmen Dogukan Sokmen Nese Ucar Huseyin Ozkurt Abdulmuttalip Simsek |
| author_sort | Bedriye Koyuncu Sokmen |
| collection | DOAJ |
| description | Purpose: Firstly, we aimed to investigate the correlation among dynamic contrasted magnetic resonance (MR) images, diffusion-weighted MR images, and apparent diffusion coefficent (ADC) values in patients with prostate cancer. Secondly, we aimed to investigate the roles of these variables on clinical risk classification and the biological behavior of the prostate cancer. Methods: A total of sixty with prostatic adenocarcinoma patients diagnosed between January 2011 and May 2013 were retrospectively included in the study. Risk classification of patients were evaluated as low-risk (Group 1) (n = 20) (Stage T1c-T2a, PSA < 10 ng/ml, Gleason Score < 7), moderate-risk (Group 2) (n = 18) (Stage T1b-T2c, PSA = 10-20 ng/ml, Gleason Score = 7) and high-risk (Group 3) (n = 22) (Stage > T3a, PSA > 20 ng/ml, Gleason Score > 7). Diffusion-weighted MR images, dynamic contrasted MR images, and ADC values of the prostates were correlated. Results: ADC values of the cases in Group 3 were lower than those of the other groups (p < 0.001). ADC values of the areas without malignancy did not differ significantly between groups (p > 0.05). Biological activity of the tumor tissue was determined by GS, while a negative correlation was observed between GSs and ADC values of the patients, (p < 0.001). Conclusion: In tumors with higher Gleason scores, lower ADC values were obtained. These measured values can play a role in the noninvasive determination of the cellularity of the tumoral mass. |
| first_indexed | 2024-12-13T07:30:27Z |
| format | Article |
| id | doaj.art-72880ecb352b49b49366348b0dd2b09f |
| institution | Directory Open Access Journal |
| issn | 1124-3562 2282-4197 |
| language | English |
| last_indexed | 2024-12-13T07:30:27Z |
| publishDate | 2017-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Archivio Italiano di Urologia e Andrologia |
| spelling | doaj.art-72880ecb352b49b49366348b0dd2b09f2022-12-21T23:55:13ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972017-12-0189427728110.4081/aiua.2017.4.2775517The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancerBedriye Koyuncu Sokmen0Dogukan Sokmen1Nese Ucar2Huseyin Ozkurt3Abdulmuttalip Simsek4Department of Radiology, Sisli Florence Nightingale Hospital IstanbulDepartment of Urology, Hospital Derindere, IstanbulDepartment of Radiology, Gaziosmanpasa Taksim Training and Research Hospital, IstanbulDepartment of Radiology, Istanbul Hamidiye Sisli Etfal Training and Research Hospital, IstanbulDepartment of Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, IstanbulPurpose: Firstly, we aimed to investigate the correlation among dynamic contrasted magnetic resonance (MR) images, diffusion-weighted MR images, and apparent diffusion coefficent (ADC) values in patients with prostate cancer. Secondly, we aimed to investigate the roles of these variables on clinical risk classification and the biological behavior of the prostate cancer. Methods: A total of sixty with prostatic adenocarcinoma patients diagnosed between January 2011 and May 2013 were retrospectively included in the study. Risk classification of patients were evaluated as low-risk (Group 1) (n = 20) (Stage T1c-T2a, PSA < 10 ng/ml, Gleason Score < 7), moderate-risk (Group 2) (n = 18) (Stage T1b-T2c, PSA = 10-20 ng/ml, Gleason Score = 7) and high-risk (Group 3) (n = 22) (Stage > T3a, PSA > 20 ng/ml, Gleason Score > 7). Diffusion-weighted MR images, dynamic contrasted MR images, and ADC values of the prostates were correlated. Results: ADC values of the cases in Group 3 were lower than those of the other groups (p < 0.001). ADC values of the areas without malignancy did not differ significantly between groups (p > 0.05). Biological activity of the tumor tissue was determined by GS, while a negative correlation was observed between GSs and ADC values of the patients, (p < 0.001). Conclusion: In tumors with higher Gleason scores, lower ADC values were obtained. These measured values can play a role in the noninvasive determination of the cellularity of the tumoral mass.http://www.pagepressjournals.org/index.php/aiua/article/view/6924Prostate cancerDynamic contrasted MRIDiffusion-weighted MRIApparent diffusion coefficient value |
| spellingShingle | Bedriye Koyuncu Sokmen Dogukan Sokmen Nese Ucar Huseyin Ozkurt Abdulmuttalip Simsek The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer Archivio Italiano di Urologia e Andrologia Prostate cancer Dynamic contrasted MRI Diffusion-weighted MRI Apparent diffusion coefficient value |
| title | The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer |
| title_full | The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer |
| title_fullStr | The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer |
| title_full_unstemmed | The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer |
| title_short | The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer |
| title_sort | correlation between biological activity and diffusion weighted mr imaging and adc value in cases with prostate cancer |
| topic | Prostate cancer Dynamic contrasted MRI Diffusion-weighted MRI Apparent diffusion coefficient value |
| url | http://www.pagepressjournals.org/index.php/aiua/article/view/6924 |
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