Conserved and divergent development of brainstem vestibular and auditory nuclei
Vestibular function was established early in vertebrates and has remained, for the most part, unchanged. In contrast, each group of tetrapods underwent independent evolutionary processes to solve the problem of hearing on land, resulting in a remarkable mixture of conserved, divergent and convergent...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-12-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/40232 |
| _version_ | 1811199813781291008 |
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| author | Marcela Lipovsek Richard JT Wingate |
| author_facet | Marcela Lipovsek Richard JT Wingate |
| author_sort | Marcela Lipovsek |
| collection | DOAJ |
| description | Vestibular function was established early in vertebrates and has remained, for the most part, unchanged. In contrast, each group of tetrapods underwent independent evolutionary processes to solve the problem of hearing on land, resulting in a remarkable mixture of conserved, divergent and convergent features that define extant auditory systems. The vestibuloacoustic nuclei of the hindbrain develop from a highly conserved ground plan and provide an ideal framework on which to address the participation of developmental processes to the evolution of neuronal circuits. We employed an electroporation strategy to unravel the contribution of two dorsoventral and four axial lineages to the development of the chick hindbrain vestibular and auditory nuclei. We compare the chick developmental map with recently established genetic fate-maps of the developing mouse hindbrain. Overall, we find considerable conservation of developmental origin for the vestibular nuclei. In contrast, a comparative analysis of the developmental origin of hindbrain auditory structures echoes the complex evolutionary history of the auditory system. In particular, we find that the developmental origin of the chick auditory interaural time difference circuit supports its emergence from an ancient vestibular network, unrelated to the analogous mammalian counterpart. |
| first_indexed | 2024-04-12T01:53:47Z |
| format | Article |
| id | doaj.art-728839b361c047189bf5b60369eea233 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:53:47Z |
| publishDate | 2018-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-728839b361c047189bf5b60369eea2332022-12-22T03:52:51ZengeLife Sciences Publications LtdeLife2050-084X2018-12-01710.7554/eLife.40232Conserved and divergent development of brainstem vestibular and auditory nucleiMarcela Lipovsek0https://orcid.org/0000-0001-9328-0328Richard JT Wingate1https://orcid.org/0000-0002-1662-6097Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United KingdomCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom; MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United KingdomVestibular function was established early in vertebrates and has remained, for the most part, unchanged. In contrast, each group of tetrapods underwent independent evolutionary processes to solve the problem of hearing on land, resulting in a remarkable mixture of conserved, divergent and convergent features that define extant auditory systems. The vestibuloacoustic nuclei of the hindbrain develop from a highly conserved ground plan and provide an ideal framework on which to address the participation of developmental processes to the evolution of neuronal circuits. We employed an electroporation strategy to unravel the contribution of two dorsoventral and four axial lineages to the development of the chick hindbrain vestibular and auditory nuclei. We compare the chick developmental map with recently established genetic fate-maps of the developing mouse hindbrain. Overall, we find considerable conservation of developmental origin for the vestibular nuclei. In contrast, a comparative analysis of the developmental origin of hindbrain auditory structures echoes the complex evolutionary history of the auditory system. In particular, we find that the developmental origin of the chick auditory interaural time difference circuit supports its emergence from an ancient vestibular network, unrelated to the analogous mammalian counterpart.https://elifesciences.org/articles/40232auditoryvestibularhindbraindevelopmentevolution |
| spellingShingle | Marcela Lipovsek Richard JT Wingate Conserved and divergent development of brainstem vestibular and auditory nuclei eLife auditory vestibular hindbrain development evolution |
| title | Conserved and divergent development of brainstem vestibular and auditory nuclei |
| title_full | Conserved and divergent development of brainstem vestibular and auditory nuclei |
| title_fullStr | Conserved and divergent development of brainstem vestibular and auditory nuclei |
| title_full_unstemmed | Conserved and divergent development of brainstem vestibular and auditory nuclei |
| title_short | Conserved and divergent development of brainstem vestibular and auditory nuclei |
| title_sort | conserved and divergent development of brainstem vestibular and auditory nuclei |
| topic | auditory vestibular hindbrain development evolution |
| url | https://elifesciences.org/articles/40232 |
| work_keys_str_mv | AT marcelalipovsek conservedanddivergentdevelopmentofbrainstemvestibularandauditorynuclei AT richardjtwingate conservedanddivergentdevelopmentofbrainstemvestibularandauditorynuclei |