Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosis
AbstractObjective To evaluate the clinical efficacy of the combination of high-intensity focused ultrasound (HIFU), mifepristone, and levonorgestrel-releasing intrauterine system (LNG-IUS) in adenomyosis treatment.Methods HIFU treatment was performed in 123 patients with symptomatic adenomyosis who...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2022.2161641 |
| _version_ | 1797374224975790080 |
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| author | Hui Zhu Qimin Ma Guoling Dong Lijun Yang Yang Li Shumin Song Yanchao Mu |
| author_facet | Hui Zhu Qimin Ma Guoling Dong Lijun Yang Yang Li Shumin Song Yanchao Mu |
| author_sort | Hui Zhu |
| collection | DOAJ |
| description | AbstractObjective To evaluate the clinical efficacy of the combination of high-intensity focused ultrasound (HIFU), mifepristone, and levonorgestrel-releasing intrauterine system (LNG-IUS) in adenomyosis treatment.Methods HIFU treatment was performed in 123 patients with symptomatic adenomyosis who had refused treatment with gonadotropin-releasing hormone agonist (GnRH-a) at Anyang Maternal and Child Health Care Hospital. In the control group, 34 patients were treated with HIFU alone, 29 patients with HIFU combined with mifepristone, 10 patients with HIFU combined with LNG-IUS. In the study group, 50 patients were treated with HIFU combined with mifepristone and LNG-IUS.Results Uterine volume, dysmenorrhea pain score, menstruation volume score, and serum CA125 level were significantly lower after treatment with HIFU combined with mifepristone and LNG-IUS than before treatment (p < .05). Moreover, hemoglobin level was significantly higher than that before treatment (p < .05). After 24 months, the efficacy of HIFU combined with mifepristone and LNG-IUS was significantly higher than that of HIFU alone, HIFU combined with mifepristone or HIFU with LNG-IUS (p < .05).Conclusions Combination therapy of HIFU, mifepristone, and LNG-IUS is an effective, safe, and inexpensive treatment for patients with symptomatic adenomyosis. This combination therapy demonstrates superior efficacy to treatment with HIFU alone, HIFU combined with mifepristone, and HIFU combined with LNG-IUS. |
| first_indexed | 2024-03-08T19:02:50Z |
| format | Article |
| id | doaj.art-7288a988baa04697bf88bd5baab216d1 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-03-08T19:02:50Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-7288a988baa04697bf88bd5baab216d12023-12-28T04:15:42ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572023-12-0140110.1080/02656736.2022.2161641Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosisHui Zhu0Qimin Ma1Guoling Dong2Lijun Yang3Yang Li4Shumin Song5Yanchao Mu6Department of Gynecology, Anyang Maternal and Child Health Care Hospital, Anyang, ChinaDepartment of Gynecology, Anyang Maternal and Child Health Care Hospital, Anyang, ChinaDepartment of Gynecology, Anyang Maternal and Child Health Care Hospital, Anyang, ChinaDepartment of Gynecology, Anyang Maternal and Child Health Care Hospital, Anyang, ChinaDepartment of Gynecology, Anyang Maternal and Child Health Care Hospital, Anyang, ChinaDepartment of Gynecology, Anyang Maternal and Child Health Care Hospital, Anyang, ChinaDepartment of Gynecology, Anyang Maternal and Child Health Care Hospital, Anyang, ChinaAbstractObjective To evaluate the clinical efficacy of the combination of high-intensity focused ultrasound (HIFU), mifepristone, and levonorgestrel-releasing intrauterine system (LNG-IUS) in adenomyosis treatment.Methods HIFU treatment was performed in 123 patients with symptomatic adenomyosis who had refused treatment with gonadotropin-releasing hormone agonist (GnRH-a) at Anyang Maternal and Child Health Care Hospital. In the control group, 34 patients were treated with HIFU alone, 29 patients with HIFU combined with mifepristone, 10 patients with HIFU combined with LNG-IUS. In the study group, 50 patients were treated with HIFU combined with mifepristone and LNG-IUS.Results Uterine volume, dysmenorrhea pain score, menstruation volume score, and serum CA125 level were significantly lower after treatment with HIFU combined with mifepristone and LNG-IUS than before treatment (p < .05). Moreover, hemoglobin level was significantly higher than that before treatment (p < .05). After 24 months, the efficacy of HIFU combined with mifepristone and LNG-IUS was significantly higher than that of HIFU alone, HIFU combined with mifepristone or HIFU with LNG-IUS (p < .05).Conclusions Combination therapy of HIFU, mifepristone, and LNG-IUS is an effective, safe, and inexpensive treatment for patients with symptomatic adenomyosis. This combination therapy demonstrates superior efficacy to treatment with HIFU alone, HIFU combined with mifepristone, and HIFU combined with LNG-IUS.https://www.tandfonline.com/doi/10.1080/02656736.2022.2161641Adenomyosishigh-intensity focused ultrasoundmifepristonelevonorgestrel-releasing intrauterine systemcombination therapy |
| spellingShingle | Hui Zhu Qimin Ma Guoling Dong Lijun Yang Yang Li Shumin Song Yanchao Mu Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosis International Journal of Hyperthermia Adenomyosis high-intensity focused ultrasound mifepristone levonorgestrel-releasing intrauterine system combination therapy |
| title | Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosis |
| title_full | Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosis |
| title_fullStr | Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosis |
| title_full_unstemmed | Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosis |
| title_short | Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosis |
| title_sort | clinical evaluation of high intensity focused ultrasound ablation combined with mifepristone and levonorgestrel releasing intrauterine system to treat symptomatic adenomyosis |
| topic | Adenomyosis high-intensity focused ultrasound mifepristone levonorgestrel-releasing intrauterine system combination therapy |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2022.2161641 |
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