Targeting 14-3-3ζ by a small-molecule compound AI-34 maintains epithelial barrier integrity and alleviates colitis in mice via stabilizing β-catenin

Targeting 14-3-3ζ by a small-molecule compound AI-34 maintains epithelial barrier integrity and alleviates colitis in mice via stabilizing β-catenin

Aberrant intestinal epithelial barrier function is the primary pathology of Ulcerative colitis (UC), making it a desirable drug target. In this study, our small-molecule compound AI-34 exerted a significant protective effect in an LPS-induced epithelial barrier injury model. In vitro, AI-34 treatmen...

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Bibliographic Details
Main Authors: Yan Li, Nannan Liu, Yao Qian, Chenyang Jiao, Jiashu Yang, Xiangbao Meng, Yang Sun, Qiang Xu, Wen Liu, Jian Cui, Wenjie Guo
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Journal of Pharmacological Sciences
Subjects:
Small-molecule compound
14-3-3ζ
β-catenin
Colitis
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000348

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