"Neutrophil Function in 8 Cases of Papillon-Lefevre Syndrome "
Statement of Problem: Papillon Lefevre syndrome (PLS) is a rate autosomal recessive disorder, which is characterized by palmar- plantar hyperkeratosis and rapid periodontal destruction of primary and permanent dentitions. Purpose: The aim of the present study was to evaluate the peripheral blood ne...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2004-03-01
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| Series: | Frontiers in Dentistry |
| Subjects: | |
| Online Access: | https://jdt.tums.ac.ir/index.php/jdt/article/view/2 |
| _version_ | 1818473239774494720 |
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| author | Lotfazar M Amirghofran Z Nicfarjam L |
| author_facet | Lotfazar M Amirghofran Z Nicfarjam L |
| author_sort | Lotfazar M |
| collection | DOAJ |
| description | Statement of Problem: Papillon Lefevre syndrome (PLS) is a rate autosomal recessive disorder, which is characterized by palmar- plantar hyperkeratosis and rapid periodontal destruction of primary and permanent dentitions.
Purpose: The aim of the present study was to evaluate the peripheral blood neutrophil function including random locomotion, chemotaxis and oxidative mechanism of killing in a group of patients with PLS.
Materials and Methods: Peripheral blood was obtained from 8 PLS patients and 92 healthy control subjects. PMN mobility was measured by a modification of the micromethod of Addison and Babbage. Latex-Stimulated NBT reduction test described by Park et al was followed. Data were analyzed by Mann Whitney U test.
Results: The chemotactic activity in the PLS group was significantly lower than control group (89.5±21.6 vs 113±16 m, P0.05).
Conclusion: The present study indicated an impaired neutrophil chemotaxis in PLS patients. |
| first_indexed | 2024-04-14T04:20:48Z |
| format | Article |
| id | doaj.art-72898dfa3130479cac071a2fdb18c71f |
| institution | Directory Open Access Journal |
| issn | 2676-296X |
| language | English |
| last_indexed | 2024-04-14T04:20:48Z |
| publishDate | 2004-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Frontiers in Dentistry |
| spelling | doaj.art-72898dfa3130479cac071a2fdb18c71f2022-12-22T02:12:32ZengTehran University of Medical SciencesFrontiers in Dentistry2676-296X2004-03-0111"Neutrophil Function in 8 Cases of Papillon-Lefevre Syndrome " Lotfazar M0 Amirghofran Z1 Nicfarjam L2 Statement of Problem: Papillon Lefevre syndrome (PLS) is a rate autosomal recessive disorder, which is characterized by palmar- plantar hyperkeratosis and rapid periodontal destruction of primary and permanent dentitions. Purpose: The aim of the present study was to evaluate the peripheral blood neutrophil function including random locomotion, chemotaxis and oxidative mechanism of killing in a group of patients with PLS. Materials and Methods: Peripheral blood was obtained from 8 PLS patients and 92 healthy control subjects. PMN mobility was measured by a modification of the micromethod of Addison and Babbage. Latex-Stimulated NBT reduction test described by Park et al was followed. Data were analyzed by Mann Whitney U test. Results: The chemotactic activity in the PLS group was significantly lower than control group (89.5±21.6 vs 113±16 m, P0.05). Conclusion: The present study indicated an impaired neutrophil chemotaxis in PLS patients.https://jdt.tums.ac.ir/index.php/jdt/article/view/2Papillon Lefevre SyndromeChemotaxisNeutrophils |
| spellingShingle | Lotfazar M Amirghofran Z Nicfarjam L "Neutrophil Function in 8 Cases of Papillon-Lefevre Syndrome " Frontiers in Dentistry Papillon Lefevre Syndrome Chemotaxis Neutrophils |
| title | "Neutrophil Function in 8 Cases of Papillon-Lefevre Syndrome " |
| title_full | "Neutrophil Function in 8 Cases of Papillon-Lefevre Syndrome " |
| title_fullStr | "Neutrophil Function in 8 Cases of Papillon-Lefevre Syndrome " |
| title_full_unstemmed | "Neutrophil Function in 8 Cases of Papillon-Lefevre Syndrome " |
| title_short | "Neutrophil Function in 8 Cases of Papillon-Lefevre Syndrome " |
| title_sort | neutrophil function in 8 cases of papillon lefevre syndrome |
| topic | Papillon Lefevre Syndrome Chemotaxis Neutrophils |
| url | https://jdt.tums.ac.ir/index.php/jdt/article/view/2 |
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