Hyperbaric Oxygen Effects on Contrast and Macular Light Sensitivity in Dry Type Age-Related Macular Degeneration Patients
This study was to compare the effectiveness of hyperbaric oxygen therapy (HBOT) on contrast and macular light sensitivity improvement in dry type age-related macular degeneration (AMD) patients. The subjects were eyes that had been diagnosed with dry type AMD which met inclusion criteria. The subjec...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2021-04-01
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| Series: | Folia Medica Indonesiana |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/FMI/article/view/9310 |
| _version_ | 1818729612068257792 |
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| author | Indriani Kartika Dewi Moestidjab Moestidjab Titut Harnanik |
| author_facet | Indriani Kartika Dewi Moestidjab Moestidjab Titut Harnanik |
| author_sort | Indriani Kartika Dewi |
| collection | DOAJ |
| description | This study was to compare the effectiveness of hyperbaric oxygen therapy (HBOT) on contrast and macular light sensitivity improvement in dry type age-related macular degeneration (AMD) patients. The subjects were eyes that had been diagnosed with dry type AMD which met inclusion criteria. The subjects were divided into two groups. The first group was given antioxidants and HBOT. The second group was given only antioxidants. Contrast and macular light sensitivity test were done using MARS contrast sensitivity chart and Humphrey Field Analyzer-3 for three times, pre-therapy, day-1 and 14 post- therapy. This study found that 25 eyes were included for analysis, 14 subjects in first group, and 11 subjects in second group. Statistical analysis results showed that there were significant increase on contrast sensitivity in intervention group between one-day post-therapy with pre-therapy, P = 0.003 (P <0.05), and between 14-days post-therapy with pre-therapy, P = 0,015 (P <0.05). From pre- and post-analysis, there were no significant difference found on contrast sensitivity in control group and macular light sensitivity in intervention group. In control group, there were significant increase on superotemporal, superonasal, and inferonasal area between one-day post-therapy and pra-therapy with P = 0.004, P = 0.013 and P = 0.008 (P <0.05), respectively, and there was significant decrease on inferonasal area between 14-days post-therapy and one-day post-therapy, P = 0.003 (P <0.05). In conclusion, patients with AMD who were subjected to HBOT achieved improvement in contrast sensitivity in cases considered as having low prognosis. HBOT should be considered as promising intervention for AMD management adjuvant and further research are needed to find optimal dosage. |
| first_indexed | 2024-12-17T22:48:39Z |
| format | Article |
| id | doaj.art-728a7d8bd85843018db070b4fc06ab37 |
| institution | Directory Open Access Journal |
| issn | 2355-8393 2599-056X |
| language | English |
| last_indexed | 2024-12-17T22:48:39Z |
| publishDate | 2021-04-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Folia Medica Indonesiana |
| spelling | doaj.art-728a7d8bd85843018db070b4fc06ab372022-12-21T21:29:43ZengUniversitas AirlanggaFolia Medica Indonesiana2355-83932599-056X2021-04-01571344010.20473/fmi.v57i1.931012210Hyperbaric Oxygen Effects on Contrast and Macular Light Sensitivity in Dry Type Age-Related Macular Degeneration PatientsIndriani Kartika Dewi0Moestidjab Moestidjab1Titut Harnanik2Ophthalmology Study Programme, Faculty of Medicine, Universitas Airlangga, SurabayaOphthalmology Department, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Hospital, SurabayaDepartment of Hyperbaric, Naval Health Institute, Surabaya, IndonesiaThis study was to compare the effectiveness of hyperbaric oxygen therapy (HBOT) on contrast and macular light sensitivity improvement in dry type age-related macular degeneration (AMD) patients. The subjects were eyes that had been diagnosed with dry type AMD which met inclusion criteria. The subjects were divided into two groups. The first group was given antioxidants and HBOT. The second group was given only antioxidants. Contrast and macular light sensitivity test were done using MARS contrast sensitivity chart and Humphrey Field Analyzer-3 for three times, pre-therapy, day-1 and 14 post- therapy. This study found that 25 eyes were included for analysis, 14 subjects in first group, and 11 subjects in second group. Statistical analysis results showed that there were significant increase on contrast sensitivity in intervention group between one-day post-therapy with pre-therapy, P = 0.003 (P <0.05), and between 14-days post-therapy with pre-therapy, P = 0,015 (P <0.05). From pre- and post-analysis, there were no significant difference found on contrast sensitivity in control group and macular light sensitivity in intervention group. In control group, there were significant increase on superotemporal, superonasal, and inferonasal area between one-day post-therapy and pra-therapy with P = 0.004, P = 0.013 and P = 0.008 (P <0.05), respectively, and there was significant decrease on inferonasal area between 14-days post-therapy and one-day post-therapy, P = 0.003 (P <0.05). In conclusion, patients with AMD who were subjected to HBOT achieved improvement in contrast sensitivity in cases considered as having low prognosis. HBOT should be considered as promising intervention for AMD management adjuvant and further research are needed to find optimal dosage.https://e-journal.unair.ac.id/FMI/article/view/9310amdhyperbaric oxygencontrast sensitivitylight sensitivity |
| spellingShingle | Indriani Kartika Dewi Moestidjab Moestidjab Titut Harnanik Hyperbaric Oxygen Effects on Contrast and Macular Light Sensitivity in Dry Type Age-Related Macular Degeneration Patients Folia Medica Indonesiana amd hyperbaric oxygen contrast sensitivity light sensitivity |
| title | Hyperbaric Oxygen Effects on Contrast and Macular Light Sensitivity in Dry Type Age-Related Macular Degeneration Patients |
| title_full | Hyperbaric Oxygen Effects on Contrast and Macular Light Sensitivity in Dry Type Age-Related Macular Degeneration Patients |
| title_fullStr | Hyperbaric Oxygen Effects on Contrast and Macular Light Sensitivity in Dry Type Age-Related Macular Degeneration Patients |
| title_full_unstemmed | Hyperbaric Oxygen Effects on Contrast and Macular Light Sensitivity in Dry Type Age-Related Macular Degeneration Patients |
| title_short | Hyperbaric Oxygen Effects on Contrast and Macular Light Sensitivity in Dry Type Age-Related Macular Degeneration Patients |
| title_sort | hyperbaric oxygen effects on contrast and macular light sensitivity in dry type age related macular degeneration patients |
| topic | amd hyperbaric oxygen contrast sensitivity light sensitivity |
| url | https://e-journal.unair.ac.id/FMI/article/view/9310 |
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