Susceptibilities of Nonhuman Primates to Chronic Wasting Disease
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids. We used 2 nonhuman primate species, cynomolgus macaques and squirrel monkeys,...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2009-09-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/15/9/09-0253_article |
| _version_ | 1818990767880798208 |
|---|---|
| author | Brent Race Kimberly D. Meade-White Michael W. Miller Kent D. Barbian Richard Rubenstein Giuseppe LaFauci Larisa Cervenakova Cynthia Favara Donald Gardner Dan Long Michael Parnell James Striebel Suzette A. Priola Anne Ward Elizabeth S. Williams Richard Race Bruce Chesebro |
| author_facet | Brent Race Kimberly D. Meade-White Michael W. Miller Kent D. Barbian Richard Rubenstein Giuseppe LaFauci Larisa Cervenakova Cynthia Favara Donald Gardner Dan Long Michael Parnell James Striebel Suzette A. Priola Anne Ward Elizabeth S. Williams Richard Race Bruce Chesebro |
| author_sort | Brent Race |
| collection | DOAJ |
| description | Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids. We used 2 nonhuman primate species, cynomolgus macaques and squirrel monkeys, as human models for CWD susceptibility. CWD was inoculated into these 2 species by intracerebral and oral routes. After intracerebral inoculation of squirrel monkeys, 7 of 8 CWD isolates induced a clinical wasting syndrome within 33–53 months. The monkeys’ brains showed spongiform encephalopathy and protease-resistant prion protein (PrPres) diagnostic of prion disease. After oral exposure, 2 squirrel monkeys had PrPres in brain, spleen, and lymph nodes at 69 months postinfection. In contrast, cynomolgus macaques have not shown evidence of clinical disease as of 70 months postinfection. Thus, these 2 species differed in susceptibility to CWD. Because humans are evolutionarily closer to macaques than to squirrel monkeys, they may also be resistant to CWD. |
| first_indexed | 2024-12-20T19:59:37Z |
| format | Article |
| id | doaj.art-728aa7a33b464b64abcff9512600d648 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-20T19:59:37Z |
| publishDate | 2009-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-728aa7a33b464b64abcff9512600d6482022-12-21T19:28:04ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592009-09-011591366137610.3201/eid1509.090253Susceptibilities of Nonhuman Primates to Chronic Wasting DiseaseBrent RaceKimberly D. Meade-WhiteMichael W. MillerKent D. BarbianRichard RubensteinGiuseppe LaFauciLarisa CervenakovaCynthia FavaraDonald GardnerDan LongMichael ParnellJames StriebelSuzette A. PriolaAnne WardElizabeth S. WilliamsRichard RaceBruce ChesebroChronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids. We used 2 nonhuman primate species, cynomolgus macaques and squirrel monkeys, as human models for CWD susceptibility. CWD was inoculated into these 2 species by intracerebral and oral routes. After intracerebral inoculation of squirrel monkeys, 7 of 8 CWD isolates induced a clinical wasting syndrome within 33–53 months. The monkeys’ brains showed spongiform encephalopathy and protease-resistant prion protein (PrPres) diagnostic of prion disease. After oral exposure, 2 squirrel monkeys had PrPres in brain, spleen, and lymph nodes at 69 months postinfection. In contrast, cynomolgus macaques have not shown evidence of clinical disease as of 70 months postinfection. Thus, these 2 species differed in susceptibility to CWD. Because humans are evolutionarily closer to macaques than to squirrel monkeys, they may also be resistant to CWD.https://wwwnc.cdc.gov/eid/article/15/9/09-0253_articleChronic wasting diseaseoral transmissionintracerebral transmissioncynomolgus macaquessquirrel monkeysTSE diseases |
| spellingShingle | Brent Race Kimberly D. Meade-White Michael W. Miller Kent D. Barbian Richard Rubenstein Giuseppe LaFauci Larisa Cervenakova Cynthia Favara Donald Gardner Dan Long Michael Parnell James Striebel Suzette A. Priola Anne Ward Elizabeth S. Williams Richard Race Bruce Chesebro Susceptibilities of Nonhuman Primates to Chronic Wasting Disease Emerging Infectious Diseases Chronic wasting disease oral transmission intracerebral transmission cynomolgus macaques squirrel monkeys TSE diseases |
| title | Susceptibilities of Nonhuman Primates to Chronic Wasting Disease |
| title_full | Susceptibilities of Nonhuman Primates to Chronic Wasting Disease |
| title_fullStr | Susceptibilities of Nonhuman Primates to Chronic Wasting Disease |
| title_full_unstemmed | Susceptibilities of Nonhuman Primates to Chronic Wasting Disease |
| title_short | Susceptibilities of Nonhuman Primates to Chronic Wasting Disease |
| title_sort | susceptibilities of nonhuman primates to chronic wasting disease |
| topic | Chronic wasting disease oral transmission intracerebral transmission cynomolgus macaques squirrel monkeys TSE diseases |
| url | https://wwwnc.cdc.gov/eid/article/15/9/09-0253_article |
| work_keys_str_mv | AT brentrace susceptibilitiesofnonhumanprimatestochronicwastingdisease AT kimberlydmeadewhite susceptibilitiesofnonhumanprimatestochronicwastingdisease AT michaelwmiller susceptibilitiesofnonhumanprimatestochronicwastingdisease AT kentdbarbian susceptibilitiesofnonhumanprimatestochronicwastingdisease AT richardrubenstein susceptibilitiesofnonhumanprimatestochronicwastingdisease AT giuseppelafauci susceptibilitiesofnonhumanprimatestochronicwastingdisease AT larisacervenakova susceptibilitiesofnonhumanprimatestochronicwastingdisease AT cynthiafavara susceptibilitiesofnonhumanprimatestochronicwastingdisease AT donaldgardner susceptibilitiesofnonhumanprimatestochronicwastingdisease AT danlong susceptibilitiesofnonhumanprimatestochronicwastingdisease AT michaelparnell susceptibilitiesofnonhumanprimatestochronicwastingdisease AT jamesstriebel susceptibilitiesofnonhumanprimatestochronicwastingdisease AT suzetteapriola susceptibilitiesofnonhumanprimatestochronicwastingdisease AT anneward susceptibilitiesofnonhumanprimatestochronicwastingdisease AT elizabethswilliams susceptibilitiesofnonhumanprimatestochronicwastingdisease AT richardrace susceptibilitiesofnonhumanprimatestochronicwastingdisease AT brucechesebro susceptibilitiesofnonhumanprimatestochronicwastingdisease |