miR-1908 Dysregulation in Human Cancers
MiR-1908 is a miRNA located in the intron of the fatty acid desaturase 1 (FADS1) gene. The expression level of miR-1908 is abnormal in many diseases such as cancer. miR-1908 can inhibit the expression of at least 27 target genes by binding to the 3’ untranslated region (3’ UTR) of target genes. miR-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.857743/full |
| _version_ | 1818394133326200832 |
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| author | Jinze Shen Yuchen Wu Wenjing Ruan Feng Zhu Shiwei Duan |
| author_facet | Jinze Shen Yuchen Wu Wenjing Ruan Feng Zhu Shiwei Duan |
| author_sort | Jinze Shen |
| collection | DOAJ |
| description | MiR-1908 is a miRNA located in the intron of the fatty acid desaturase 1 (FADS1) gene. The expression level of miR-1908 is abnormal in many diseases such as cancer. miR-1908 can inhibit the expression of at least 27 target genes by binding to the 3’ untranslated region (3’ UTR) of target genes. miR-1908 is involved in the biological processes of cell proliferation, cell differentiation, cell apoptosis, cancer cell invasion, and metastasis. The expression of miR-1908 is regulated by 11 factors, including lncRNA HOTTIP, adipokines (TNF-α, leptin, and resistin), NF-κB, free fatty acid (FFA), cholesterol, stearoyl-CoA desaturase (SCD1), immune-related transcription factors (STAT1, RB1, and IRF1). The expression of miR-1908 is also affected by the anticancer drug OSW-1, growth hormone (GH), and the anticonvulsant drug sodium valproate. In addition, the aberrant expression of miR-1908 is also related to the prognosis of a variety of cancers, including non-small cell lung cancer (NSCLC), ovarian cancer (OC), breast cancer, cervical cancer, glioma, high-grade serous ovarian carcinoma (HGSOC), osteosarcoma, etc. This article summarizes the abnormal expression pattern of miR-1908 in various diseases and its molecular regulation mechanisms. Our work will provide potential hints and direction for future miR-1908-related research. |
| first_indexed | 2024-12-14T05:56:22Z |
| format | Article |
| id | doaj.art-728b53cf0b8148cd83b17535610bd528 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T05:56:22Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-728b53cf0b8148cd83b17535610bd5282022-12-21T23:14:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.857743857743miR-1908 Dysregulation in Human CancersJinze Shen0Yuchen Wu1Wenjing Ruan2Feng Zhu3Shiwei Duan4Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou, ChinaDepartment of Clinical Medicine, The First School of Medicine, Wenzhou Medical University, Wenzhou, ChinaSir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou, ChinaDepartment of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou, ChinaMiR-1908 is a miRNA located in the intron of the fatty acid desaturase 1 (FADS1) gene. The expression level of miR-1908 is abnormal in many diseases such as cancer. miR-1908 can inhibit the expression of at least 27 target genes by binding to the 3’ untranslated region (3’ UTR) of target genes. miR-1908 is involved in the biological processes of cell proliferation, cell differentiation, cell apoptosis, cancer cell invasion, and metastasis. The expression of miR-1908 is regulated by 11 factors, including lncRNA HOTTIP, adipokines (TNF-α, leptin, and resistin), NF-κB, free fatty acid (FFA), cholesterol, stearoyl-CoA desaturase (SCD1), immune-related transcription factors (STAT1, RB1, and IRF1). The expression of miR-1908 is also affected by the anticancer drug OSW-1, growth hormone (GH), and the anticonvulsant drug sodium valproate. In addition, the aberrant expression of miR-1908 is also related to the prognosis of a variety of cancers, including non-small cell lung cancer (NSCLC), ovarian cancer (OC), breast cancer, cervical cancer, glioma, high-grade serous ovarian carcinoma (HGSOC), osteosarcoma, etc. This article summarizes the abnormal expression pattern of miR-1908 in various diseases and its molecular regulation mechanisms. Our work will provide potential hints and direction for future miR-1908-related research.https://www.frontiersin.org/articles/10.3389/fonc.2022.857743/fullmiR-1908ceRNAcancerdiagnosisprognosis |
| spellingShingle | Jinze Shen Yuchen Wu Wenjing Ruan Feng Zhu Shiwei Duan miR-1908 Dysregulation in Human Cancers Frontiers in Oncology miR-1908 ceRNA cancer diagnosis prognosis |
| title | miR-1908 Dysregulation in Human Cancers |
| title_full | miR-1908 Dysregulation in Human Cancers |
| title_fullStr | miR-1908 Dysregulation in Human Cancers |
| title_full_unstemmed | miR-1908 Dysregulation in Human Cancers |
| title_short | miR-1908 Dysregulation in Human Cancers |
| title_sort | mir 1908 dysregulation in human cancers |
| topic | miR-1908 ceRNA cancer diagnosis prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.857743/full |
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