Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review
Aging is characterized by a progressive decline or loss of physiological functions, leading to increased susceptibility to disease or death. Several aging hallmarks, including genomic instability, cellular senescence, and mitochondrial dysfunction, have been suggested, which often lead to the numero...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/1/58 |
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| author | Yu Gyung Kim Sang Min Lee Sungeun Bae Taejun Park Hyeonjin Kim Yujeong Jang Keonwoo Moon Hyungmin Kim Kwangmin Lee Joonyoung Park Jin-Seok Byun Do-Yeon Kim |
| author_facet | Yu Gyung Kim Sang Min Lee Sungeun Bae Taejun Park Hyeonjin Kim Yujeong Jang Keonwoo Moon Hyungmin Kim Kwangmin Lee Joonyoung Park Jin-Seok Byun Do-Yeon Kim |
| author_sort | Yu Gyung Kim |
| collection | DOAJ |
| description | Aging is characterized by a progressive decline or loss of physiological functions, leading to increased susceptibility to disease or death. Several aging hallmarks, including genomic instability, cellular senescence, and mitochondrial dysfunction, have been suggested, which often lead to the numerous aging disorders. The periodontium, a complex structure surrounding and supporting the teeth, is composed of the gingiva, periodontal ligament, cementum, and alveolar bone. Supportive and protective roles of the periodontium are very critical to sustain life, but the periodontium undergoes morphological and physiological changes with age. In this review, we summarize the current knowledge of molecular and cellular physiological changes in the periodontium, by focusing on soft tissues including gingiva and periodontal ligament. |
| first_indexed | 2024-03-09T04:26:51Z |
| format | Article |
| id | doaj.art-728cf4f44fee4c928320e6ce5386cb8e |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T04:26:51Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-728cf4f44fee4c928320e6ce5386cb8e2023-12-03T13:39:33ZengMDPI AGJournal of Personalized Medicine2075-44262021-01-011115810.3390/jpm11010058Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative ReviewYu Gyung Kim0Sang Min Lee1Sungeun Bae2Taejun Park3Hyeonjin Kim4Yujeong Jang5Keonwoo Moon6Hyungmin Kim7Kwangmin Lee8Joonyoung Park9Jin-Seok Byun10Do-Yeon Kim11Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Pharmacology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, Daegu 41940, KoreaAging is characterized by a progressive decline or loss of physiological functions, leading to increased susceptibility to disease or death. Several aging hallmarks, including genomic instability, cellular senescence, and mitochondrial dysfunction, have been suggested, which often lead to the numerous aging disorders. The periodontium, a complex structure surrounding and supporting the teeth, is composed of the gingiva, periodontal ligament, cementum, and alveolar bone. Supportive and protective roles of the periodontium are very critical to sustain life, but the periodontium undergoes morphological and physiological changes with age. In this review, we summarize the current knowledge of molecular and cellular physiological changes in the periodontium, by focusing on soft tissues including gingiva and periodontal ligament.https://www.mdpi.com/2075-4426/11/1/58agingperiodontiumgingivaperiodontal ligamentMMP |
| spellingShingle | Yu Gyung Kim Sang Min Lee Sungeun Bae Taejun Park Hyeonjin Kim Yujeong Jang Keonwoo Moon Hyungmin Kim Kwangmin Lee Joonyoung Park Jin-Seok Byun Do-Yeon Kim Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review Journal of Personalized Medicine aging periodontium gingiva periodontal ligament MMP |
| title | Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review |
| title_full | Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review |
| title_fullStr | Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review |
| title_full_unstemmed | Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review |
| title_short | Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review |
| title_sort | effect of aging on homeostasis in the soft tissue of the periodontium a narrative review |
| topic | aging periodontium gingiva periodontal ligament MMP |
| url | https://www.mdpi.com/2075-4426/11/1/58 |
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