Ferroptosis Meets Cell–Cell Contacts
Ferroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/9/2462 |
| _version_ | 1797519834240516096 |
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| author | Cornelia Dietrich Thomas G. Hofmann |
| author_facet | Cornelia Dietrich Thomas G. Hofmann |
| author_sort | Cornelia Dietrich |
| collection | DOAJ |
| description | Ferroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues. Deregulated ferroptosis has been linked to human diseases, such as neurodegenerative diseases, cardiovascular disorders, and cancer. Along these lines, ferroptosis is a promising pathway to overcoming therapy resistance of cancer cells. It is therefore of utmost importance to understand the cellular signalling pathways and the molecular mechanisms underlying ferroptosis regulation, including context-specific effects mediated by the neighbouring cells through cell–cell contacts. Here, we give an overview on the molecular events and machinery linked to ferroptosis induction and commitment. We further summarize and discuss current knowledge about the role of cell–cell contacts, which differ in ferroptosis regulation between normal somatic cells and cancer cells. We present emerging concepts on the underlying mechanisms, address open questions, and discuss the possible impact of cell–cell contacts on exploiting ferroptosis in cancer therapy. |
| first_indexed | 2024-03-10T07:48:24Z |
| format | Article |
| id | doaj.art-728e9fb1e853444db618c87ac9aef921 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:48:24Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-728e9fb1e853444db618c87ac9aef9212023-11-22T12:26:34ZengMDPI AGCells2073-44092021-09-01109246210.3390/cells10092462Ferroptosis Meets Cell–Cell ContactsCornelia Dietrich0Thomas G. Hofmann1Institute of Toxicology, University Medical Center of the Johannes Gutenberg-University, Obere Zahlbacher Str. 67, 55131 Mainz, GermanyInstitute of Toxicology, University Medical Center of the Johannes Gutenberg-University, Obere Zahlbacher Str. 67, 55131 Mainz, GermanyFerroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues. Deregulated ferroptosis has been linked to human diseases, such as neurodegenerative diseases, cardiovascular disorders, and cancer. Along these lines, ferroptosis is a promising pathway to overcoming therapy resistance of cancer cells. It is therefore of utmost importance to understand the cellular signalling pathways and the molecular mechanisms underlying ferroptosis regulation, including context-specific effects mediated by the neighbouring cells through cell–cell contacts. Here, we give an overview on the molecular events and machinery linked to ferroptosis induction and commitment. We further summarize and discuss current knowledge about the role of cell–cell contacts, which differ in ferroptosis regulation between normal somatic cells and cancer cells. We present emerging concepts on the underlying mechanisms, address open questions, and discuss the possible impact of cell–cell contacts on exploiting ferroptosis in cancer therapy.https://www.mdpi.com/2073-4409/10/9/2462ferroptosiscell–cell contactsepithelial–mesenchymal transitioncancer therapy |
| spellingShingle | Cornelia Dietrich Thomas G. Hofmann Ferroptosis Meets Cell–Cell Contacts Cells ferroptosis cell–cell contacts epithelial–mesenchymal transition cancer therapy |
| title | Ferroptosis Meets Cell–Cell Contacts |
| title_full | Ferroptosis Meets Cell–Cell Contacts |
| title_fullStr | Ferroptosis Meets Cell–Cell Contacts |
| title_full_unstemmed | Ferroptosis Meets Cell–Cell Contacts |
| title_short | Ferroptosis Meets Cell–Cell Contacts |
| title_sort | ferroptosis meets cell cell contacts |
| topic | ferroptosis cell–cell contacts epithelial–mesenchymal transition cancer therapy |
| url | https://www.mdpi.com/2073-4409/10/9/2462 |
| work_keys_str_mv | AT corneliadietrich ferroptosismeetscellcellcontacts AT thomasghofmann ferroptosismeetscellcellcontacts |