Epidemiology and risk factors for carbapenemase-producing Enterobacteriaceae carriage in the hospital: A population-based nested case-control study
ABSTRACT: Objectives: This study aims to study the epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in Hong Kong. Methods: This is a longitudinal population-based study reporting monthly CPE incidence rate and a nested case-control study for identifying risk factors for CPE carriage...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
|
| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716523000577 |
| _version_ | 1797802242362834944 |
|---|---|
| author | Min Fan Shuk-Ching Wong Qiuyan Yu Philip H Li Peng Wu Esther Wai Yin Chan Ian Chi Kei Wong Hein M Tun Benjamin John Cowling Vincent Chi-Chung Cheng Celine Sze Ling Chui |
| author_facet | Min Fan Shuk-Ching Wong Qiuyan Yu Philip H Li Peng Wu Esther Wai Yin Chan Ian Chi Kei Wong Hein M Tun Benjamin John Cowling Vincent Chi-Chung Cheng Celine Sze Ling Chui |
| author_sort | Min Fan |
| collection | DOAJ |
| description | ABSTRACT: Objectives: This study aims to study the epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in Hong Kong. Methods: This is a longitudinal population-based study reporting monthly CPE incidence rate and a nested case-control study for identifying risk factors for CPE carriage. The cases were patients with at least one CPE-positive genotypic test, while the controls were randomly selected from the cohort with negative tests. Up to four controls per case were matched by sex, age group, and admission year-month. The independent risk factors were identified from a conditional logistic regression with potential covariates. Results: From 1 January 2008 to 31 December 2019, 8588 patients received CPE genotyping tests, and 2353 had at least one positive result. Class B carbapenemase was the predominant enzyme in the samples (78.6%). The incidence rate increased from 0.04 in 2015 to 1.62 in 2019 per 10,000 person-year. In the nested case-control study, 1709 cases and 6664 controls were matched. Previous use of any beta-lactam antibiotics (odds ratio:1.37 [1.22–1.53], P < 0.001) was found as an independent risk factor for carriage of CPE. Conclusion: The carriage of CPE was found with an increasing trend in Hong Kong. Previous use of any beta-lactam antibiotics is a risk factor for CPE. |
| first_indexed | 2024-03-13T05:02:33Z |
| format | Article |
| id | doaj.art-728ec149d0ab4097ababe2860d00f11b |
| institution | Directory Open Access Journal |
| issn | 2213-7165 |
| language | English |
| last_indexed | 2024-03-13T05:02:33Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj.art-728ec149d0ab4097ababe2860d00f11b2023-06-17T05:18:31ZengElsevierJournal of Global Antimicrobial Resistance2213-71652023-06-0133242248Epidemiology and risk factors for carbapenemase-producing Enterobacteriaceae carriage in the hospital: A population-based nested case-control studyMin Fan0Shuk-Ching Wong1Qiuyan Yu2Philip H Li3Peng Wu4Esther Wai Yin Chan5Ian Chi Kei Wong6Hein M Tun7Benjamin John Cowling8Vincent Chi-Chung Cheng9Celine Sze Ling Chui10Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaInfection Control Team, Queen Mary Hospital, Hong Kong SAR, ChinaCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaDivision of Rheumatology and Clinical Immunology, Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Hong Kong SAR, ChinaCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Hong Kong SAR, ChinaCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Hong Kong SAR, China; Aston Pharmacy School, Aston University, Birmingham, B4 7ET, United KingdomSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, ChinaWorld Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Hong Kong SAR, ChinaInfection Control Team, Queen Mary Hospital, Hong Kong SAR, China; Department of Microbiology, Queen Mary Hospital, Hong Kong SAR, ChinaLaboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Hong Kong SAR, China; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Corresponding author. Mailing address: 5/F, 3 Sassoon Road, Pokfulam, Hong Kong.ABSTRACT: Objectives: This study aims to study the epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in Hong Kong. Methods: This is a longitudinal population-based study reporting monthly CPE incidence rate and a nested case-control study for identifying risk factors for CPE carriage. The cases were patients with at least one CPE-positive genotypic test, while the controls were randomly selected from the cohort with negative tests. Up to four controls per case were matched by sex, age group, and admission year-month. The independent risk factors were identified from a conditional logistic regression with potential covariates. Results: From 1 January 2008 to 31 December 2019, 8588 patients received CPE genotyping tests, and 2353 had at least one positive result. Class B carbapenemase was the predominant enzyme in the samples (78.6%). The incidence rate increased from 0.04 in 2015 to 1.62 in 2019 per 10,000 person-year. In the nested case-control study, 1709 cases and 6664 controls were matched. Previous use of any beta-lactam antibiotics (odds ratio:1.37 [1.22–1.53], P < 0.001) was found as an independent risk factor for carriage of CPE. Conclusion: The carriage of CPE was found with an increasing trend in Hong Kong. Previous use of any beta-lactam antibiotics is a risk factor for CPE.http://www.sciencedirect.com/science/article/pii/S2213716523000577Carbapenemase-producing EnterobacteriaceaeCarriageNested case-control studyRisk factorEpidemiology |
| spellingShingle | Min Fan Shuk-Ching Wong Qiuyan Yu Philip H Li Peng Wu Esther Wai Yin Chan Ian Chi Kei Wong Hein M Tun Benjamin John Cowling Vincent Chi-Chung Cheng Celine Sze Ling Chui Epidemiology and risk factors for carbapenemase-producing Enterobacteriaceae carriage in the hospital: A population-based nested case-control study Journal of Global Antimicrobial Resistance Carbapenemase-producing Enterobacteriaceae Carriage Nested case-control study Risk factor Epidemiology |
| title | Epidemiology and risk factors for carbapenemase-producing Enterobacteriaceae carriage in the hospital: A population-based nested case-control study |
| title_full | Epidemiology and risk factors for carbapenemase-producing Enterobacteriaceae carriage in the hospital: A population-based nested case-control study |
| title_fullStr | Epidemiology and risk factors for carbapenemase-producing Enterobacteriaceae carriage in the hospital: A population-based nested case-control study |
| title_full_unstemmed | Epidemiology and risk factors for carbapenemase-producing Enterobacteriaceae carriage in the hospital: A population-based nested case-control study |
| title_short | Epidemiology and risk factors for carbapenemase-producing Enterobacteriaceae carriage in the hospital: A population-based nested case-control study |
| title_sort | epidemiology and risk factors for carbapenemase producing enterobacteriaceae carriage in the hospital a population based nested case control study |
| topic | Carbapenemase-producing Enterobacteriaceae Carriage Nested case-control study Risk factor Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S2213716523000577 |
| work_keys_str_mv | AT minfan epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy AT shukchingwong epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy AT qiuyanyu epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy AT philiphli epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy AT pengwu epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy AT estherwaiyinchan epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy AT ianchikeiwong epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy AT heinmtun epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy AT benjaminjohncowling epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy AT vincentchichungcheng epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy AT celineszelingchui epidemiologyandriskfactorsforcarbapenemaseproducingenterobacteriaceaecarriageinthehospitalapopulationbasednestedcasecontrolstudy |