Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation
Abstract Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However, whether and how lysosomes mediate the mitochondrial stress response (MSR) remain largely unknown. Here, we demonstrate that lysosomal acidificatio...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-09-01
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| Series: | Cell Discovery |
| Online Access: | https://doi.org/10.1038/s41421-023-00589-1 |