Optimization of acute medication use following eptinezumab initiation during a migraine attack: post hoc analysis of the RELIEF study
Abstract Background The benefits of preventive treatment on the effectiveness of migraine management have rarely been examined. This post hoc analysis investigated the impact of eptinezumab on the optimization of acute medication effectiveness using the 4-item Migraine Treatment Optimization Questio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-022-01463-3 |
| _version_ | 1811222870313926656 |
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| author | Roger Cady Richard B. Lipton Dawn C. Buse Mette Krog Josiassen Annika Lindsten Anders Ettrup |
| author_facet | Roger Cady Richard B. Lipton Dawn C. Buse Mette Krog Josiassen Annika Lindsten Anders Ettrup |
| author_sort | Roger Cady |
| collection | DOAJ |
| description | Abstract Background The benefits of preventive treatment on the effectiveness of migraine management have rarely been examined. This post hoc analysis investigated the impact of eptinezumab on the optimization of acute medication effectiveness using the 4-item Migraine Treatment Optimization Questionnaire (mTOQ-4) to measure acute medication optimization over 4 weeks post-infusion. Methods RELIEF was a 12-week, phase 3, multicenter, parallel-group, double-blind, placebo-controlled clinical trial conducted in patients aged 18–75 years with a ≥ 1-year history of migraine and 4–15 migraine days per month in the 3 months prior to screening. Patients were randomized 1:1 to a 30-min infusion of eptinezumab 100 mg or placebo within 1–6 h of a qualifying migraine attack. The mTOQ-6 and 6-item Headache Impact Test (HIT-6) were administered at screening visit and week 4. From the mTOQ-6, we calculated the mTOQ-4 using the following items: “2-h pain free,” “24-h relief,” “able to plan,” and “feeling in control” to measure acute medication optimization. Results A total of 238 patients received eptinezumab 100 mg and 226 provided week 4 data; 242 received placebo and 232 provided week 4 data. In the eptinezumab arm, the proportion of patients with moderate/maximal optimization increased from 31.4% at baseline to 58.0% (26.6 percentage point increase) at week 4. The corresponding proportions in the placebo group were 40.5% to 50.4% (9.9 percentage point increase). Eptinezumab treatment was associated with numerically larger improvements in HIT-6 at week 4. Relative improvements with eptinezumab vs. placebo from baseline to week 4 in HIT-6 were greater in those with poor treatment optimization at baseline. Conclusions In comparison with placebo, treatment with eptinezumab was associated with improvements in acute medication optimization as measured by mTOQ and reductions in headache impact, as measured by HIT-6. These benefits were greater in those with poor acute treatment optimization prior to preventive treatment with eptinezumab. Trial registration ClinicalTrials.gov identifier: NCT04152083 . |
| first_indexed | 2024-04-12T08:23:05Z |
| format | Article |
| id | doaj.art-7294224df94c4a88a383591a4d4856b6 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-04-12T08:23:05Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-7294224df94c4a88a383591a4d4856b62022-12-22T03:40:30ZengBMCThe Journal of Headache and Pain1129-23691129-23772022-07-012311910.1186/s10194-022-01463-3Optimization of acute medication use following eptinezumab initiation during a migraine attack: post hoc analysis of the RELIEF studyRoger Cady0Richard B. Lipton1Dawn C. Buse2Mette Krog Josiassen3Annika Lindsten4Anders Ettrup5RK ConsultsDepartment of Neurology, Albert Einstein College of MedicineDepartment of Neurology, Albert Einstein College of MedicineH. Lundbeck A/SH. Lundbeck A/SH. Lundbeck A/SAbstract Background The benefits of preventive treatment on the effectiveness of migraine management have rarely been examined. This post hoc analysis investigated the impact of eptinezumab on the optimization of acute medication effectiveness using the 4-item Migraine Treatment Optimization Questionnaire (mTOQ-4) to measure acute medication optimization over 4 weeks post-infusion. Methods RELIEF was a 12-week, phase 3, multicenter, parallel-group, double-blind, placebo-controlled clinical trial conducted in patients aged 18–75 years with a ≥ 1-year history of migraine and 4–15 migraine days per month in the 3 months prior to screening. Patients were randomized 1:1 to a 30-min infusion of eptinezumab 100 mg or placebo within 1–6 h of a qualifying migraine attack. The mTOQ-6 and 6-item Headache Impact Test (HIT-6) were administered at screening visit and week 4. From the mTOQ-6, we calculated the mTOQ-4 using the following items: “2-h pain free,” “24-h relief,” “able to plan,” and “feeling in control” to measure acute medication optimization. Results A total of 238 patients received eptinezumab 100 mg and 226 provided week 4 data; 242 received placebo and 232 provided week 4 data. In the eptinezumab arm, the proportion of patients with moderate/maximal optimization increased from 31.4% at baseline to 58.0% (26.6 percentage point increase) at week 4. The corresponding proportions in the placebo group were 40.5% to 50.4% (9.9 percentage point increase). Eptinezumab treatment was associated with numerically larger improvements in HIT-6 at week 4. Relative improvements with eptinezumab vs. placebo from baseline to week 4 in HIT-6 were greater in those with poor treatment optimization at baseline. Conclusions In comparison with placebo, treatment with eptinezumab was associated with improvements in acute medication optimization as measured by mTOQ and reductions in headache impact, as measured by HIT-6. These benefits were greater in those with poor acute treatment optimization prior to preventive treatment with eptinezumab. Trial registration ClinicalTrials.gov identifier: NCT04152083 .https://doi.org/10.1186/s10194-022-01463-3MigraineEptinezumabCGRPmTOQ |
| spellingShingle | Roger Cady Richard B. Lipton Dawn C. Buse Mette Krog Josiassen Annika Lindsten Anders Ettrup Optimization of acute medication use following eptinezumab initiation during a migraine attack: post hoc analysis of the RELIEF study The Journal of Headache and Pain Migraine Eptinezumab CGRP mTOQ |
| title | Optimization of acute medication use following eptinezumab initiation during a migraine attack: post hoc analysis of the RELIEF study |
| title_full | Optimization of acute medication use following eptinezumab initiation during a migraine attack: post hoc analysis of the RELIEF study |
| title_fullStr | Optimization of acute medication use following eptinezumab initiation during a migraine attack: post hoc analysis of the RELIEF study |
| title_full_unstemmed | Optimization of acute medication use following eptinezumab initiation during a migraine attack: post hoc analysis of the RELIEF study |
| title_short | Optimization of acute medication use following eptinezumab initiation during a migraine attack: post hoc analysis of the RELIEF study |
| title_sort | optimization of acute medication use following eptinezumab initiation during a migraine attack post hoc analysis of the relief study |
| topic | Migraine Eptinezumab CGRP mTOQ |
| url | https://doi.org/10.1186/s10194-022-01463-3 |
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