Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies
BackgroundNeuroinflammation is a response that involves different cell lineages of the central nervous system, such as neurons and glial cells. Among the non-pharmacological interventions for neuroinflammation, photobiomodulation (PBM) is gaining prominence because of its beneficial effects found in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1006031/full |
| _version_ | 1818021332450803712 |
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| author | Fabrízio dos Santos Cardoso Farzad Salehpour Norberto Cysne Coimbra Francisco Gonzalez-Lima Sérgio Gomes da Silva Sérgio Gomes da Silva |
| author_facet | Fabrízio dos Santos Cardoso Farzad Salehpour Norberto Cysne Coimbra Francisco Gonzalez-Lima Sérgio Gomes da Silva Sérgio Gomes da Silva |
| author_sort | Fabrízio dos Santos Cardoso |
| collection | DOAJ |
| description | BackgroundNeuroinflammation is a response that involves different cell lineages of the central nervous system, such as neurons and glial cells. Among the non-pharmacological interventions for neuroinflammation, photobiomodulation (PBM) is gaining prominence because of its beneficial effects found in experimental brain research. We systematically reviewed the effects of PBM on laboratory animal models, specially to investigate potential benefits of PBM as an efficient anti-inflammatory therapy.MethodsWe conducted a systematic search on the bibliographic databases (PubMed and ScienceDirect) with the keywords based on MeSH terms: photobiomodulation, low-level laser therapy, brain, neuroinflammation, inflammation, cytokine, and microglia. Data search was limited from 2009 to June 2022. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The initial systematic search identified 140 articles. Among them, 54 articles were removed for duplication and 59 articles by screening. Therefore, 27 studies met the inclusion criteria.ResultsThe studies showed that PBM has anti-inflammatory properties in several conditions, such as traumatic brain injury, edema formation and hyperalgesia, ischemia, neurodegenerative conditions, aging, epilepsy, depression, and spinal cord injury.ConclusionTaken together, these results indicate that transcranial PBM therapy is a promising strategy to treat brain pathological conditions induced by neuroinflammation. |
| first_indexed | 2024-04-14T08:16:46Z |
| format | Article |
| id | doaj.art-72948872cfd742aa950fc6953743c247 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-14T08:16:46Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-72948872cfd742aa950fc6953743c2472022-12-22T02:04:22ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-09-011610.3389/fnins.2022.10060311006031Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studiesFabrízio dos Santos Cardoso0Farzad Salehpour1Norberto Cysne Coimbra2Francisco Gonzalez-Lima3Sérgio Gomes da Silva4Sérgio Gomes da Silva5Departamento de Farmacologia, Faculdade de Medicina de Ribeirão da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, BrazilDepartment of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX, United StatesDepartamento de Farmacologia, Faculdade de Medicina de Ribeirão da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, BrazilDepartment of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX, United StatesCentro Universitário UNIFAMINAS (UNIFAMINAS), Muriaé, MG, BrazilHospital do Câncer de Muriaé, Fundação Cristiano Varella (FCV), Muriaé, MG, BrazilBackgroundNeuroinflammation is a response that involves different cell lineages of the central nervous system, such as neurons and glial cells. Among the non-pharmacological interventions for neuroinflammation, photobiomodulation (PBM) is gaining prominence because of its beneficial effects found in experimental brain research. We systematically reviewed the effects of PBM on laboratory animal models, specially to investigate potential benefits of PBM as an efficient anti-inflammatory therapy.MethodsWe conducted a systematic search on the bibliographic databases (PubMed and ScienceDirect) with the keywords based on MeSH terms: photobiomodulation, low-level laser therapy, brain, neuroinflammation, inflammation, cytokine, and microglia. Data search was limited from 2009 to June 2022. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The initial systematic search identified 140 articles. Among them, 54 articles were removed for duplication and 59 articles by screening. Therefore, 27 studies met the inclusion criteria.ResultsThe studies showed that PBM has anti-inflammatory properties in several conditions, such as traumatic brain injury, edema formation and hyperalgesia, ischemia, neurodegenerative conditions, aging, epilepsy, depression, and spinal cord injury.ConclusionTaken together, these results indicate that transcranial PBM therapy is a promising strategy to treat brain pathological conditions induced by neuroinflammation.https://www.frontiersin.org/articles/10.3389/fnins.2022.1006031/fullphotobiomodulationlow-level laser (light) therapybrainneuroinflammationinflammationcytokine |
| spellingShingle | Fabrízio dos Santos Cardoso Farzad Salehpour Norberto Cysne Coimbra Francisco Gonzalez-Lima Sérgio Gomes da Silva Sérgio Gomes da Silva Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies Frontiers in Neuroscience photobiomodulation low-level laser (light) therapy brain neuroinflammation inflammation cytokine |
| title | Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies |
| title_full | Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies |
| title_fullStr | Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies |
| title_full_unstemmed | Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies |
| title_short | Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies |
| title_sort | photobiomodulation for the treatment of neuroinflammation a systematic review of controlled laboratory animal studies |
| topic | photobiomodulation low-level laser (light) therapy brain neuroinflammation inflammation cytokine |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1006031/full |
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