CT perfusion in evaluation of post therapy cervical lymphoma
Objective: Compare CT perfusion between responders and non-responders in patients with residual cervical nodes after lymphoma treatment. Subjects and methods: Twenty-seven patients with treated pathologically proved lymphoma were included in this prospective study, divided into two groups: responder...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2016-12-01
|
| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X16301164 |
| _version_ | 1818503715891445760 |
|---|---|
| author | Nihal M. Batouty Amina A. Sultan Nazem A. Shams Nahed Abd El-Gaber Mahmoud A. Rashed |
| author_facet | Nihal M. Batouty Amina A. Sultan Nazem A. Shams Nahed Abd El-Gaber Mahmoud A. Rashed |
| author_sort | Nihal M. Batouty |
| collection | DOAJ |
| description | Objective: Compare CT perfusion between responders and non-responders in patients with residual cervical nodes after lymphoma treatment.
Subjects and methods: Twenty-seven patients with treated pathologically proved lymphoma were included in this prospective study, divided into two groups: responders (n. 15) and non-responders to treatment (n. 12). Blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability (PS) were determined using CT perfusion. Lymph nodes sizes were measured (short axis).
Results: BF, BV and PS were significantly higher in non-responders group [93.3 (65.3–111) ml/min/100 g, 6.3 (5.2–8) ml/100 g and 18.9 (14.5–25.1) ml/min/100 g respectively] as compared to responders group [54 (43.8–77.5) ml/min/100 g, 4.1 (2.2–4.8) ml/100 g and 9.4 (7.5–14.5) ml/min/100 g respectively], [p 0.019, 0.004 and 0.004 respectively]. MTT had a trend to be low in non-responders group, but did not reach statistical significance (p 0.305). Cutoff value for BF, BV and PS was 59.5 ml/min/100 g, 3.6 ml/100 g and 11.1 ml/min/100 g respectively, 92% sensitivity for the three parameters and specificity 67%, 47% and 73% respectively. Lymph node sizes had no relation to the perfusion parameter values.
Conclusion: CT perfusion is a functional imaging tool with promising results in differentiating between responders and non-responders in treated lymphoma patients, using BF, BV and PS. |
| first_indexed | 2024-12-10T21:27:41Z |
| format | Article |
| id | doaj.art-7294f33235574c0191bce02f6fee12b7 |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-12-10T21:27:41Z |
| publishDate | 2016-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-7294f33235574c0191bce02f6fee12b72022-12-22T01:32:57ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2016-12-014741673167910.1016/j.ejrnm.2016.07.012CT perfusion in evaluation of post therapy cervical lymphomaNihal M. BatoutyAmina A. SultanNazem A. ShamsNahed Abd El-GaberMahmoud A. RashedObjective: Compare CT perfusion between responders and non-responders in patients with residual cervical nodes after lymphoma treatment. Subjects and methods: Twenty-seven patients with treated pathologically proved lymphoma were included in this prospective study, divided into two groups: responders (n. 15) and non-responders to treatment (n. 12). Blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability (PS) were determined using CT perfusion. Lymph nodes sizes were measured (short axis). Results: BF, BV and PS were significantly higher in non-responders group [93.3 (65.3–111) ml/min/100 g, 6.3 (5.2–8) ml/100 g and 18.9 (14.5–25.1) ml/min/100 g respectively] as compared to responders group [54 (43.8–77.5) ml/min/100 g, 4.1 (2.2–4.8) ml/100 g and 9.4 (7.5–14.5) ml/min/100 g respectively], [p 0.019, 0.004 and 0.004 respectively]. MTT had a trend to be low in non-responders group, but did not reach statistical significance (p 0.305). Cutoff value for BF, BV and PS was 59.5 ml/min/100 g, 3.6 ml/100 g and 11.1 ml/min/100 g respectively, 92% sensitivity for the three parameters and specificity 67%, 47% and 73% respectively. Lymph node sizes had no relation to the perfusion parameter values. Conclusion: CT perfusion is a functional imaging tool with promising results in differentiating between responders and non-responders in treated lymphoma patients, using BF, BV and PS.http://www.sciencedirect.com/science/article/pii/S0378603X16301164CT perfusionLymphomaCervical lymphadenopathy |
| spellingShingle | Nihal M. Batouty Amina A. Sultan Nazem A. Shams Nahed Abd El-Gaber Mahmoud A. Rashed CT perfusion in evaluation of post therapy cervical lymphoma The Egyptian Journal of Radiology and Nuclear Medicine CT perfusion Lymphoma Cervical lymphadenopathy |
| title | CT perfusion in evaluation of post therapy cervical lymphoma |
| title_full | CT perfusion in evaluation of post therapy cervical lymphoma |
| title_fullStr | CT perfusion in evaluation of post therapy cervical lymphoma |
| title_full_unstemmed | CT perfusion in evaluation of post therapy cervical lymphoma |
| title_short | CT perfusion in evaluation of post therapy cervical lymphoma |
| title_sort | ct perfusion in evaluation of post therapy cervical lymphoma |
| topic | CT perfusion Lymphoma Cervical lymphadenopathy |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X16301164 |
| work_keys_str_mv | AT nihalmbatouty ctperfusioninevaluationofposttherapycervicallymphoma AT aminaasultan ctperfusioninevaluationofposttherapycervicallymphoma AT nazemashams ctperfusioninevaluationofposttherapycervicallymphoma AT nahedabdelgaber ctperfusioninevaluationofposttherapycervicallymphoma AT mahmoudarashed ctperfusioninevaluationofposttherapycervicallymphoma |