Systemic sarcoidosis with bone marrow involvement responding to therapy with adalimumab: a case report
<p>Abstract</p> <p>Introduction</p> <p>Sarcoidosis is an inflammatory disorder characterized by the presence of non-caseating granulomas in affected organs. The presence of CD4-positive T lymphocytes and macrophages in affected organs suggests an ongoing immune response...
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| Format: | Article |
| Language: | English |
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BMC
2009-07-01
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| Series: | Journal of Medical Case Reports |
| Online Access: | http://www.jmedicalcasereports.com/content/3/1/8573 |
| _version_ | 1811321735357661184 |
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| author | Patel Supen R |
| author_facet | Patel Supen R |
| author_sort | Patel Supen R |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>Sarcoidosis is an inflammatory disorder characterized by the presence of non-caseating granulomas in affected organs. The presence of CD4-positive T lymphocytes and macrophages in affected organs suggests an ongoing immune response. Systemic corticosteroids remain the mainstay of treatment, but therapy is often limited by adverse effects. This is the first report of the use of adalimumab (HUMIRA<sup>®</sup>, Abbott Laboratories, North Chicago, IL, USA), an anti-tumor necrosis factor monoclonal antibody, in a patient with systemic sarcoidosis with bone marrow involvement.</p> <p>Case presentation</p> <p>A 42-year-old African-American man with a medical history significant for hypertension and diabetes mellitus presented with anemia and thrombocytopenia of two months duration. The patient underwent physical examination, bone marrow aspiration and biopsy, chest X-ray, acid-fast bacilli stain, computed tomography with contrast, and additional laboratory tests. He was diagnosed with systemic sarcoidosis with splenomegaly and bone marrow involvement. Drug therapy included prednisone, which had to be discontinued owing to adverse effects, and adalimumab.</p> <p>Conclusion</p> <p>This is the first report describing the use of adalimumab in a patient with systemic sarcoidosis with bone marrow involvement. Tumor necrosis factor antagonism with adalimumab was efficacious and well-tolerated in this patient and may be considered as a treatment option for similar cases.</p> |
| first_indexed | 2024-04-13T13:22:48Z |
| format | Article |
| id | doaj.art-72950e5b68f74faba4fba6c93d801bfd |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-13T13:22:48Z |
| publishDate | 2009-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-72950e5b68f74faba4fba6c93d801bfd2022-12-22T02:45:15ZengBMCJournal of Medical Case Reports1752-19472009-07-0131857310.4076/1752-1947-3-8573Systemic sarcoidosis with bone marrow involvement responding to therapy with adalimumab: a case reportPatel Supen R<p>Abstract</p> <p>Introduction</p> <p>Sarcoidosis is an inflammatory disorder characterized by the presence of non-caseating granulomas in affected organs. The presence of CD4-positive T lymphocytes and macrophages in affected organs suggests an ongoing immune response. Systemic corticosteroids remain the mainstay of treatment, but therapy is often limited by adverse effects. This is the first report of the use of adalimumab (HUMIRA<sup>®</sup>, Abbott Laboratories, North Chicago, IL, USA), an anti-tumor necrosis factor monoclonal antibody, in a patient with systemic sarcoidosis with bone marrow involvement.</p> <p>Case presentation</p> <p>A 42-year-old African-American man with a medical history significant for hypertension and diabetes mellitus presented with anemia and thrombocytopenia of two months duration. The patient underwent physical examination, bone marrow aspiration and biopsy, chest X-ray, acid-fast bacilli stain, computed tomography with contrast, and additional laboratory tests. He was diagnosed with systemic sarcoidosis with splenomegaly and bone marrow involvement. Drug therapy included prednisone, which had to be discontinued owing to adverse effects, and adalimumab.</p> <p>Conclusion</p> <p>This is the first report describing the use of adalimumab in a patient with systemic sarcoidosis with bone marrow involvement. Tumor necrosis factor antagonism with adalimumab was efficacious and well-tolerated in this patient and may be considered as a treatment option for similar cases.</p>http://www.jmedicalcasereports.com/content/3/1/8573 |
| spellingShingle | Patel Supen R Systemic sarcoidosis with bone marrow involvement responding to therapy with adalimumab: a case report Journal of Medical Case Reports |
| title | Systemic sarcoidosis with bone marrow involvement responding to therapy with adalimumab: a case report |
| title_full | Systemic sarcoidosis with bone marrow involvement responding to therapy with adalimumab: a case report |
| title_fullStr | Systemic sarcoidosis with bone marrow involvement responding to therapy with adalimumab: a case report |
| title_full_unstemmed | Systemic sarcoidosis with bone marrow involvement responding to therapy with adalimumab: a case report |
| title_short | Systemic sarcoidosis with bone marrow involvement responding to therapy with adalimumab: a case report |
| title_sort | systemic sarcoidosis with bone marrow involvement responding to therapy with adalimumab a case report |
| url | http://www.jmedicalcasereports.com/content/3/1/8573 |
| work_keys_str_mv | AT patelsupenr systemicsarcoidosiswithbonemarrowinvolvementrespondingtotherapywithadalimumabacasereport |