Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma
The prognosis of multiple myeloma patients varies widely. Here, to identify genetic factors associated with differing prognoses, the authors carried out a meta-analysis of four genome-wide association studies and identified a risk variant associated with survival interval.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10290 |
| _version_ | 1818420229640814592 |
|---|---|
| author | David C. Johnson Niels Weinhold Jonathan S. Mitchell Bowang Chen Martin Kaiser Dil B. Begum Jens Hillengass Uta Bertsch Walter A. Gregory David Cairns Graham H. Jackson Asta Försti Jolanta Nickel Per Hoffmann Markus M. Nöethen Owen W. Stephens Bart Barlogie Faith E. Davis Kari Hemminki Hartmut Goldschmidt Richard S. Houlston Gareth J. Morgan |
| author_facet | David C. Johnson Niels Weinhold Jonathan S. Mitchell Bowang Chen Martin Kaiser Dil B. Begum Jens Hillengass Uta Bertsch Walter A. Gregory David Cairns Graham H. Jackson Asta Försti Jolanta Nickel Per Hoffmann Markus M. Nöethen Owen W. Stephens Bart Barlogie Faith E. Davis Kari Hemminki Hartmut Goldschmidt Richard S. Houlston Gareth J. Morgan |
| author_sort | David C. Johnson |
| collection | DOAJ |
| description | The prognosis of multiple myeloma patients varies widely. Here, to identify genetic factors associated with differing prognoses, the authors carried out a meta-analysis of four genome-wide association studies and identified a risk variant associated with survival interval. |
| first_indexed | 2024-12-14T12:51:09Z |
| format | Article |
| id | doaj.art-7295b3d0d9804f8f8eee173bdad4235a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T12:51:09Z |
| publishDate | 2016-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7295b3d0d9804f8f8eee173bdad4235a2022-12-21T23:00:40ZengNature PortfolioNature Communications2041-17232016-01-01711710.1038/ncomms10290Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myelomaDavid C. Johnson0Niels Weinhold1Jonathan S. Mitchell2Bowang Chen3Martin Kaiser4Dil B. Begum5Jens Hillengass6Uta Bertsch7Walter A. Gregory8David Cairns9Graham H. Jackson10Asta Försti11Jolanta Nickel12Per Hoffmann13Markus M. Nöethen14Owen W. Stephens15Bart Barlogie16Faith E. Davis17Kari Hemminki18Hartmut Goldschmidt19Richard S. Houlston20Gareth J. Morgan21Division of Molecular Pathology, The Institute of Cancer ResearchMyeloma Institute, University of Arkansas for Medical SciencesDivision of Genetics and Epidemiology, The Institute of Cancer ResearchGerman Cancer Research CenterDivision of Molecular Pathology, The Institute of Cancer ResearchDivision of Molecular Pathology, The Institute of Cancer ResearchDepartment of Internal Medicine V, University of HeidelbergDepartment of Internal Medicine V, University of HeidelbergLeeds Institute of Molecular Medicine, Section of Clinical Trials Research, University of LeedsLeeds Institute of Molecular Medicine, Section of Clinical Trials Research, University of LeedsDepartment of Haematology, Newcastle UniversityGerman Cancer Research CenterDepartment of Internal Medicine V, University of HeidelbergInstitute of Human Genetics, University of BonnInstitute of Human Genetics, University of BonnMyeloma Institute, University of Arkansas for Medical SciencesMyeloma Institute, University of Arkansas for Medical SciencesMyeloma Institute, University of Arkansas for Medical SciencesGerman Cancer Research CenterDepartment of Internal Medicine V, University of HeidelbergDivision of Molecular Pathology, The Institute of Cancer ResearchMyeloma Institute, University of Arkansas for Medical SciencesThe prognosis of multiple myeloma patients varies widely. Here, to identify genetic factors associated with differing prognoses, the authors carried out a meta-analysis of four genome-wide association studies and identified a risk variant associated with survival interval.https://doi.org/10.1038/ncomms10290 |
| spellingShingle | David C. Johnson Niels Weinhold Jonathan S. Mitchell Bowang Chen Martin Kaiser Dil B. Begum Jens Hillengass Uta Bertsch Walter A. Gregory David Cairns Graham H. Jackson Asta Försti Jolanta Nickel Per Hoffmann Markus M. Nöethen Owen W. Stephens Bart Barlogie Faith E. Davis Kari Hemminki Hartmut Goldschmidt Richard S. Houlston Gareth J. Morgan Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma Nature Communications |
| title | Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma |
| title_full | Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma |
| title_fullStr | Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma |
| title_full_unstemmed | Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma |
| title_short | Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma |
| title_sort | genome wide association study identifies variation at 6q25 1 associated with survival in multiple myeloma |
| url | https://doi.org/10.1038/ncomms10290 |
| work_keys_str_mv | AT davidcjohnson genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT nielsweinhold genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT jonathansmitchell genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT bowangchen genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT martinkaiser genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT dilbbegum genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT jenshillengass genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT utabertsch genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT walteragregory genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT davidcairns genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT grahamhjackson genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT astaforsti genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT jolantanickel genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT perhoffmann genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT markusmnoethen genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT owenwstephens genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT bartbarlogie genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT faithedavis genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT karihemminki genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT hartmutgoldschmidt genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT richardshoulston genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma AT garethjmorgan genomewideassociationstudyidentifiesvariationat6q251associatedwithsurvivalinmultiplemyeloma |