Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
Bone metastasis is a major complication of breast cancer (BC) and ER+ tumors have a higher incidence of bone metastasis than ER− tumors. Here, the authors report that miR‐19a in exosomes and the bone matrix protein, IBSP, are upregulated and secreted by bone tropic ER+ BC cells, where they cooperati...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25473-y |
| _version_ | 1818401296774856704 |
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| author | Kerui Wu Jiamei Feng Feng Lyu Fei Xing Sambad Sharma Yin Liu Shih-Ying Wu Dan Zhao Abhishek Tyagi Ravindra Pramod Deshpande Xinhong Pei Marco Gabril Ruiz Hiroyuki Takahashi Shunsuke Tsuzuki Takahiro Kimura Yin-yuan Mo Yusuke Shiozawa Ravi Singh Kounosuke Watabe |
| author_facet | Kerui Wu Jiamei Feng Feng Lyu Fei Xing Sambad Sharma Yin Liu Shih-Ying Wu Dan Zhao Abhishek Tyagi Ravindra Pramod Deshpande Xinhong Pei Marco Gabril Ruiz Hiroyuki Takahashi Shunsuke Tsuzuki Takahiro Kimura Yin-yuan Mo Yusuke Shiozawa Ravi Singh Kounosuke Watabe |
| author_sort | Kerui Wu |
| collection | DOAJ |
| description | Bone metastasis is a major complication of breast cancer (BC) and ER+ tumors have a higher incidence of bone metastasis than ER− tumors. Here, the authors report that miR‐19a in exosomes and the bone matrix protein, IBSP, are upregulated and secreted by bone tropic ER+ BC cells, where they cooperatively induce osteoclastogenesis and promote bone colonization. |
| first_indexed | 2024-12-14T07:50:13Z |
| format | Article |
| id | doaj.art-7296b39706fa487aa5244bf2e2e92852 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:50:13Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7296b39706fa487aa5244bf2e2e928522022-12-21T23:10:44ZengNature PortfolioNature Communications2041-17232021-08-0112111810.1038/s41467-021-25473-yExosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancerKerui Wu0Jiamei Feng1Feng Lyu2Fei Xing3Sambad Sharma4Yin Liu5Shih-Ying Wu6Dan Zhao7Abhishek Tyagi8Ravindra Pramod Deshpande9Xinhong Pei10Marco Gabril Ruiz11Hiroyuki Takahashi12Shunsuke Tsuzuki13Takahiro Kimura14Yin-yuan Mo15Yusuke Shiozawa16Ravi Singh17Kounosuke Watabe18Department of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Pathology, Jikei University School of MedicineDepartment of Pathology, Jikei University School of MedicineDepartment of Pathology, Jikei University School of MedicineCancer Institute, University of Mississippi Medical CenterDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineDepartment of Cancer Biology, Wake Forest University School of MedicineBone metastasis is a major complication of breast cancer (BC) and ER+ tumors have a higher incidence of bone metastasis than ER− tumors. Here, the authors report that miR‐19a in exosomes and the bone matrix protein, IBSP, are upregulated and secreted by bone tropic ER+ BC cells, where they cooperatively induce osteoclastogenesis and promote bone colonization.https://doi.org/10.1038/s41467-021-25473-y |
| spellingShingle | Kerui Wu Jiamei Feng Feng Lyu Fei Xing Sambad Sharma Yin Liu Shih-Ying Wu Dan Zhao Abhishek Tyagi Ravindra Pramod Deshpande Xinhong Pei Marco Gabril Ruiz Hiroyuki Takahashi Shunsuke Tsuzuki Takahiro Kimura Yin-yuan Mo Yusuke Shiozawa Ravi Singh Kounosuke Watabe Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer Nature Communications |
| title | Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer |
| title_full | Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer |
| title_fullStr | Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer |
| title_full_unstemmed | Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer |
| title_short | Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer |
| title_sort | exosomal mir 19a and ibsp cooperate to induce osteolytic bone metastasis of estrogen receptor positive breast cancer |
| url | https://doi.org/10.1038/s41467-021-25473-y |
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