A Rare Case of Acute Myeloblastc Leukemia With Blast Count Less Than 20% in Bone Marrow
One of the diagnostic criteria for Acute Myeloblastic Leukemia (AML) is the presence of 20% myeloid blasts in peripheral blood or bone marrow. Some cases with recurrent cytogenetic abnormalities also fall in this category with blast cell count less than 20%. Thus, in the presence of these genetic ab...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2019-07-01
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| Series: | Case Reports in Clinical Practice |
| Subjects: | |
| Online Access: | https://crcp.tums.ac.ir/index.php/crcp/article/view/210 |
| _version_ | 1811259721343041536 |
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| author | Pardis Nematollahi Behnaz Sabaghi Alireza Moafi |
| author_facet | Pardis Nematollahi Behnaz Sabaghi Alireza Moafi |
| author_sort | Pardis Nematollahi |
| collection | DOAJ |
| description | One of the diagnostic criteria for Acute Myeloblastic Leukemia (AML) is the presence of 20% myeloid blasts in peripheral blood or bone marrow. Some cases with recurrent cytogenetic abnormalities also fall in this category with blast cell count less than 20%. Thus, in the presence of these genetic abnormalities, the patients are classified as AML regardless of blast cell count. One of these genetic heterogeneities is t(8; 21) (q22, q22.1) which is more commonly seen in children and young adults. In this study, a 14-year-old boy is reported with a final diagnosis of AML, which was presented with fever and bicytopenia, clinically suspicious for acute leukemia. Laboratory results reported less than 20% blasts in bone marrow aspiration smears but genetic alteration t(8; 21) (q22, q22.1) was detected by molecular exams. |
| first_indexed | 2024-04-12T18:35:59Z |
| format | Article |
| id | doaj.art-72990d563b2e4e928966f8469ffc6e99 |
| institution | Directory Open Access Journal |
| issn | 2538-2683 2538-2691 |
| language | English |
| last_indexed | 2024-04-12T18:35:59Z |
| publishDate | 2019-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Case Reports in Clinical Practice |
| spelling | doaj.art-72990d563b2e4e928966f8469ffc6e992022-12-22T03:20:56ZengTehran University of Medical SciencesCase Reports in Clinical Practice2538-26832538-26912019-07-014110.18502/crcp.v4i1.1298A Rare Case of Acute Myeloblastc Leukemia With Blast Count Less Than 20% in Bone MarrowPardis Nematollahi0Behnaz Sabaghi1Alireza Moafi2Department of Hematopathology, Shiraz University of Medical Sciences, Shiraz, Iran. AND Department of Pathology, School of Medicine, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Pediatric Hematology and Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.One of the diagnostic criteria for Acute Myeloblastic Leukemia (AML) is the presence of 20% myeloid blasts in peripheral blood or bone marrow. Some cases with recurrent cytogenetic abnormalities also fall in this category with blast cell count less than 20%. Thus, in the presence of these genetic abnormalities, the patients are classified as AML regardless of blast cell count. One of these genetic heterogeneities is t(8; 21) (q22, q22.1) which is more commonly seen in children and young adults. In this study, a 14-year-old boy is reported with a final diagnosis of AML, which was presented with fever and bicytopenia, clinically suspicious for acute leukemia. Laboratory results reported less than 20% blasts in bone marrow aspiration smears but genetic alteration t(8; 21) (q22, q22.1) was detected by molecular exams.https://crcp.tums.ac.ir/index.php/crcp/article/view/210Acute myeloblastic leukemiaBone marrow examinationCytogenetic abnormality |
| spellingShingle | Pardis Nematollahi Behnaz Sabaghi Alireza Moafi A Rare Case of Acute Myeloblastc Leukemia With Blast Count Less Than 20% in Bone Marrow Case Reports in Clinical Practice Acute myeloblastic leukemia Bone marrow examination Cytogenetic abnormality |
| title | A Rare Case of Acute Myeloblastc Leukemia With Blast Count Less Than 20% in Bone Marrow |
| title_full | A Rare Case of Acute Myeloblastc Leukemia With Blast Count Less Than 20% in Bone Marrow |
| title_fullStr | A Rare Case of Acute Myeloblastc Leukemia With Blast Count Less Than 20% in Bone Marrow |
| title_full_unstemmed | A Rare Case of Acute Myeloblastc Leukemia With Blast Count Less Than 20% in Bone Marrow |
| title_short | A Rare Case of Acute Myeloblastc Leukemia With Blast Count Less Than 20% in Bone Marrow |
| title_sort | rare case of acute myeloblastc leukemia with blast count less than 20 in bone marrow |
| topic | Acute myeloblastic leukemia Bone marrow examination Cytogenetic abnormality |
| url | https://crcp.tums.ac.ir/index.php/crcp/article/view/210 |
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