Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for Dentists
Osteonecrosis of the jaws is a complication after treatment with antiresorptive drugs. Bisphosphonates (BPs) are widely used to treat conditions with bone metastases of malignant tumors such as multiple myeloma, breast cancer, prostatic cancer, as well as hypercalcemia of malignancy, osteoporosis, P...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-06-01
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| Series: | Journal of Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/jim-2017-0046 |
| _version_ | 1818582173443162112 |
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| author | Albu-Stan Ioana-Aurița Albu Daniel-Emil Cerghizan Diana Eremie Lia Yero Jánosi Kinga Baloș Monica Copotoiu Constantin |
| author_facet | Albu-Stan Ioana-Aurița Albu Daniel-Emil Cerghizan Diana Eremie Lia Yero Jánosi Kinga Baloș Monica Copotoiu Constantin |
| author_sort | Albu-Stan Ioana-Aurița |
| collection | DOAJ |
| description | Osteonecrosis of the jaws is a complication after treatment with antiresorptive drugs. Bisphosphonates (BPs) are widely used to treat conditions with bone metastases of malignant tumors such as multiple myeloma, breast cancer, prostatic cancer, as well as hypercalcemia of malignancy, osteoporosis, Paget’s disease, and osteogenesis imperfecta. Denosumab is an antiresorptive agent that is used for the treatment of osteoporosis or metastatic bone diseases. These antiresorptive agents improve the quality of life of patients by increasing strength and bone mineral density, and reducing the risk of bone fractures. More than a decade had passed since the first publication of this pathology, and the occurrence of the disease, its pathophysiology, and proper treatment methods are still not fully elucidated. Prevention is critical in medication-related osteonecrosis of the jaw, because the treatment is difficult, and there are no universally accepted treatment protocols. There is an accepted approach of palliation of symptoms and controlling the associated infections. Treatment may follow one of three procedures: conservative management of pain, conservative or extensive (segmental) surgery, depending on the disease stage. |
| first_indexed | 2024-12-16T07:45:11Z |
| format | Article |
| id | doaj.art-729ae8dc32884e4a9b8e41204a9c81ef |
| institution | Directory Open Access Journal |
| issn | 2501-8132 |
| language | English |
| last_indexed | 2024-12-16T07:45:11Z |
| publishDate | 2017-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Interdisciplinary Medicine |
| spelling | doaj.art-729ae8dc32884e4a9b8e41204a9c81ef2022-12-21T22:38:58ZengSciendoJournal of Interdisciplinary Medicine2501-81322017-06-012211712110.1515/jim-2017-0046jim-2017-0046Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for DentistsAlbu-Stan Ioana-Aurița0Albu Daniel-Emil1Cerghizan Diana2Eremie Lia Yero3Jánosi Kinga4Baloș Monica5Copotoiu Constantin6University of Medicine and Pharmacy, Tîrgu Mureș, RomaniaDepartment of Orthopedic Surgery and Traumatology I, County Emergency Clinical Hospital, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaDepartment of Surgery, University of Medicine and Pharmacy, Tîrgu Mureș, RomaniaOsteonecrosis of the jaws is a complication after treatment with antiresorptive drugs. Bisphosphonates (BPs) are widely used to treat conditions with bone metastases of malignant tumors such as multiple myeloma, breast cancer, prostatic cancer, as well as hypercalcemia of malignancy, osteoporosis, Paget’s disease, and osteogenesis imperfecta. Denosumab is an antiresorptive agent that is used for the treatment of osteoporosis or metastatic bone diseases. These antiresorptive agents improve the quality of life of patients by increasing strength and bone mineral density, and reducing the risk of bone fractures. More than a decade had passed since the first publication of this pathology, and the occurrence of the disease, its pathophysiology, and proper treatment methods are still not fully elucidated. Prevention is critical in medication-related osteonecrosis of the jaw, because the treatment is difficult, and there are no universally accepted treatment protocols. There is an accepted approach of palliation of symptoms and controlling the associated infections. Treatment may follow one of three procedures: conservative management of pain, conservative or extensive (segmental) surgery, depending on the disease stage.https://doi.org/10.1515/jim-2017-0046osteonecrosisbisphosphonatesantiresorptive drugssurgeryquality of life |
| spellingShingle | Albu-Stan Ioana-Aurița Albu Daniel-Emil Cerghizan Diana Eremie Lia Yero Jánosi Kinga Baloș Monica Copotoiu Constantin Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for Dentists Journal of Interdisciplinary Medicine osteonecrosis bisphosphonates antiresorptive drugs surgery quality of life |
| title | Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for Dentists |
| title_full | Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for Dentists |
| title_fullStr | Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for Dentists |
| title_full_unstemmed | Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for Dentists |
| title_short | Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for Dentists |
| title_sort | medication related osteonecrosis of the jaw a brief review treatment and practical guidelines for dentists |
| topic | osteonecrosis bisphosphonates antiresorptive drugs surgery quality of life |
| url | https://doi.org/10.1515/jim-2017-0046 |
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