Serum 8-isoprostane increased in pre-eclampsia
Background The main causes of maternal mortality in Indonesia are pre-eclampsia, hemorrhage, and infection. Oxidative stress has a primary role in pre-eclampsia and one of its parameters is 8-isoprostane serum level. The objective of this study is to measure 8-isoprostane and to analyze the relatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine Trisakti University
2015-12-01
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| Series: | Universa Medicina |
| Subjects: | |
| Online Access: | https://univmed.org/ejurnal/index.php/medicina/article/view/112 |
| _version_ | 1811206507845386240 |
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| author | Besari Adi Pramono Herman Kristanto |
| author_facet | Besari Adi Pramono Herman Kristanto |
| author_sort | Besari Adi Pramono |
| collection | DOAJ |
| description | Background
The main causes of maternal mortality in Indonesia are pre-eclampsia, hemorrhage, and infection. Oxidative stress has a primary role in pre-eclampsia and one of its parameters is 8-isoprostane serum level. The objective of this study is to measure 8-isoprostane and to analyze the relationship between 8-isoprostane level and birth weight in pre-eclampsia.
Methods
A cross-sectional study involving 23 pre-eclampsia and 29 normotensive pregnant women with normal or cesarean delivery at Dr. Kariadi Hospital Semarang from January to May 2011. Collected maternal blood samples were assessed for 8-Isoprostane levels by means of a specific ELISA kit. Neonatal birth weight was measured immediately after delivery by means of calibrated baby scales. Differences in 8-isoprostane levels between pre-eclampsia and normotensive women were assessed using independent t-test for normal distributed data, and the Mann-Whitney test for non-normally distributed data.
Results
Mean 8-isoprostane level was significantly higher in women with pre-eclampsia than in normotensive women (62.52 ± 12.19 pg/mL vs 28.64 ± 8.81 pg/mL) (p<0.05). Low birth weight was twice as frequent in pre-eclampsia than in normotensives. There was no correlation between 8-isoprostane serum level and neonatal birth weight in pre-eclampsia.
Conclusion
The level of 8-isoprostane was higher in pre-eclampsia than in normotensives. It is recommended to conduct further studies to determine whether 8-isoprostane may be used as a predictive marker of pre-eclampsia. |
| first_indexed | 2024-04-12T03:49:50Z |
| format | Article |
| id | doaj.art-729ba9cd5aef468db7177bab27482a85 |
| institution | Directory Open Access Journal |
| issn | 1907-3062 2407-2230 |
| language | English |
| last_indexed | 2024-04-12T03:49:50Z |
| publishDate | 2015-12-01 |
| publisher | Faculty of Medicine Trisakti University |
| record_format | Article |
| series | Universa Medicina |
| spelling | doaj.art-729ba9cd5aef468db7177bab27482a852022-12-22T03:49:02ZengFaculty of Medicine Trisakti UniversityUniversa Medicina1907-30622407-22302015-12-01311435110.18051/UnivMed.2012.v31.43-51104Serum 8-isoprostane increased in pre-eclampsiaBesari Adi Pramono0Herman Kristanto1Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Diponegoro University / Dr. Kariadi Hospital SemarangFetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Diponegoro University / Dr. Kariadi Hospital SemarangBackground The main causes of maternal mortality in Indonesia are pre-eclampsia, hemorrhage, and infection. Oxidative stress has a primary role in pre-eclampsia and one of its parameters is 8-isoprostane serum level. The objective of this study is to measure 8-isoprostane and to analyze the relationship between 8-isoprostane level and birth weight in pre-eclampsia. Methods A cross-sectional study involving 23 pre-eclampsia and 29 normotensive pregnant women with normal or cesarean delivery at Dr. Kariadi Hospital Semarang from January to May 2011. Collected maternal blood samples were assessed for 8-Isoprostane levels by means of a specific ELISA kit. Neonatal birth weight was measured immediately after delivery by means of calibrated baby scales. Differences in 8-isoprostane levels between pre-eclampsia and normotensive women were assessed using independent t-test for normal distributed data, and the Mann-Whitney test for non-normally distributed data. Results Mean 8-isoprostane level was significantly higher in women with pre-eclampsia than in normotensive women (62.52 ± 12.19 pg/mL vs 28.64 ± 8.81 pg/mL) (p<0.05). Low birth weight was twice as frequent in pre-eclampsia than in normotensives. There was no correlation between 8-isoprostane serum level and neonatal birth weight in pre-eclampsia. Conclusion The level of 8-isoprostane was higher in pre-eclampsia than in normotensives. It is recommended to conduct further studies to determine whether 8-isoprostane may be used as a predictive marker of pre-eclampsia.https://univmed.org/ejurnal/index.php/medicina/article/view/1128-isoprostane levelbirth weightpre-eclampsia |
| spellingShingle | Besari Adi Pramono Herman Kristanto Serum 8-isoprostane increased in pre-eclampsia Universa Medicina 8-isoprostane level birth weight pre-eclampsia |
| title | Serum 8-isoprostane increased in pre-eclampsia |
| title_full | Serum 8-isoprostane increased in pre-eclampsia |
| title_fullStr | Serum 8-isoprostane increased in pre-eclampsia |
| title_full_unstemmed | Serum 8-isoprostane increased in pre-eclampsia |
| title_short | Serum 8-isoprostane increased in pre-eclampsia |
| title_sort | serum 8 isoprostane increased in pre eclampsia |
| topic | 8-isoprostane level birth weight pre-eclampsia |
| url | https://univmed.org/ejurnal/index.php/medicina/article/view/112 |
| work_keys_str_mv | AT besariadipramono serum8isoprostaneincreasedinpreeclampsia AT hermankristanto serum8isoprostaneincreasedinpreeclampsia |