Nanotechnology for research and treatment of the intestine
Abstract The establishment of intestinal in vitro models is crucial for elucidating intestinal cell-microbe intrinsic connections and interaction mechanisms to advance normalized intestinal diagnosis and precision therapy. This review discusses the application of nanomaterials in mucosal therapy and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01517-3 |
| _version_ | 1811236375783014400 |
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| author | Yanquan Fei Yong Ma Huaizu Zhang Hao Li Guangfu Feng Jun Fang |
| author_facet | Yanquan Fei Yong Ma Huaizu Zhang Hao Li Guangfu Feng Jun Fang |
| author_sort | Yanquan Fei |
| collection | DOAJ |
| description | Abstract The establishment of intestinal in vitro models is crucial for elucidating intestinal cell-microbe intrinsic connections and interaction mechanisms to advance normalized intestinal diagnosis and precision therapy. This review discusses the application of nanomaterials in mucosal therapy and mechanism research in combination with the study of nanoscaffold in vitro models of the gut. By reviewing the original properties of nanomaterials synthesized by different physicochemical principles and modifying the original properties, the contribution of nanomaterials to solving the problems of short survival period, low cell differentiation rate, and poor reduction ability in traditional intestinal models is explored. According to nanomaterials’ different diagnostic mediators and therapeutic targets, the current diagnostic principles in inflammatory bowel disease, intestinal cancer, and other diseases are summarized inductively. In addition, the mechanism of action of nanomedicines in repairing mucosa, inhibiting inflammation, and alleviating the disease process is also discussed. Through such systematic elaboration, it offers a basis for nanomaterials to help advance in vitro research on the intestine and provide precision treatments in the clinic. |
| first_indexed | 2024-04-12T12:08:06Z |
| format | Article |
| id | doaj.art-729c15dedf3d44be91807fd7576482d0 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-12T12:08:06Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-729c15dedf3d44be91807fd7576482d02022-12-22T03:33:39ZengBMCJournal of Nanobiotechnology1477-31552022-09-0120112010.1186/s12951-022-01517-3Nanotechnology for research and treatment of the intestineYanquan Fei0Yong Ma1Huaizu Zhang2Hao Li3Guangfu Feng4Jun Fang5College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryCollege of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryCollege of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultrySchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen UniversityCollege of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryCollege of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryAbstract The establishment of intestinal in vitro models is crucial for elucidating intestinal cell-microbe intrinsic connections and interaction mechanisms to advance normalized intestinal diagnosis and precision therapy. This review discusses the application of nanomaterials in mucosal therapy and mechanism research in combination with the study of nanoscaffold in vitro models of the gut. By reviewing the original properties of nanomaterials synthesized by different physicochemical principles and modifying the original properties, the contribution of nanomaterials to solving the problems of short survival period, low cell differentiation rate, and poor reduction ability in traditional intestinal models is explored. According to nanomaterials’ different diagnostic mediators and therapeutic targets, the current diagnostic principles in inflammatory bowel disease, intestinal cancer, and other diseases are summarized inductively. In addition, the mechanism of action of nanomedicines in repairing mucosa, inhibiting inflammation, and alleviating the disease process is also discussed. Through such systematic elaboration, it offers a basis for nanomaterials to help advance in vitro research on the intestine and provide precision treatments in the clinic.https://doi.org/10.1186/s12951-022-01517-3NanotechnologyIn vitro modelingIntestinal diseasePrecision treatment |
| spellingShingle | Yanquan Fei Yong Ma Huaizu Zhang Hao Li Guangfu Feng Jun Fang Nanotechnology for research and treatment of the intestine Journal of Nanobiotechnology Nanotechnology In vitro modeling Intestinal disease Precision treatment |
| title | Nanotechnology for research and treatment of the intestine |
| title_full | Nanotechnology for research and treatment of the intestine |
| title_fullStr | Nanotechnology for research and treatment of the intestine |
| title_full_unstemmed | Nanotechnology for research and treatment of the intestine |
| title_short | Nanotechnology for research and treatment of the intestine |
| title_sort | nanotechnology for research and treatment of the intestine |
| topic | Nanotechnology In vitro modeling Intestinal disease Precision treatment |
| url | https://doi.org/10.1186/s12951-022-01517-3 |
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