PNP inhibitors selectively kill cancer cells lacking SAMHD1

PNP inhibitors selectively kill cancer cells lacking SAMHD1

Purine nucleoside phosphorylase inhibitors (PNP-Is) were developed to ablate transformed lymphocytes. However, only some patients with leukemia benefit from PNP-Is. We provide a molecular explanation: the deoxyribonucleoside triphosphate (dNTP) hydrolase SAM and HD domain-containing protein 1 (SAMHD...

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Bibliographic Details
Main Authors:	Tamara Davenne, Jan Rehwinkel
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2020-11-01
Series:	Molecular & Cellular Oncology
Subjects:	pnp forodesine samhd1 leukemia cll
Online Access:	http://dx.doi.org/10.1080/23723556.2020.1804308

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