Experience in the use of docosahexaenoic acid (BrudiPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology
Male factor is the reason of infertility in almost half of marriages. Infertile men have the percentage of sperm with violations of DNA integrity of over 30 %; with that, healthy fertile men have that indicator of less than 15 %. Understanding of importance of damages of sperm DNA is growing with di...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2015-08-01
|
| Series: | Андрология и генитальная хирургия |
| Subjects: | |
| Online Access: | https://agx.abvpress.ru/jour/article/view/146 |
| _version_ | 1827992410193395712 |
|---|---|
| author | A. Yu. Popova S. I. Gamidov R. I. Ovchinnikov I. V. Ushakova O. N. Golubeva |
| author_facet | A. Yu. Popova S. I. Gamidov R. I. Ovchinnikov I. V. Ushakova O. N. Golubeva |
| author_sort | A. Yu. Popova |
| collection | DOAJ |
| description | Male factor is the reason of infertility in almost half of marriages. Infertile men have the percentage of sperm with violations of DNA integrity of over 30 %; with that, healthy fertile men have that indicator of less than 15 %. Understanding of importance of damages of sperm DNA is growing with distribution ofauxiliary reproductive technologies. As of today, these consequences have not been studies yet, and the therapeutic effect of intake of antioxidants has not direct correlation with the sperm DNA fragmentation level. Docosahexaenoic acid is one of the most valuable omega-3 polyunsaturated fatty acids for human health. Docosahexaenoic acid is the main component of the brain gray matter, retina, testes, and sperm cell membranes. In connection with that, a study was held the purpose of which was to assess the effect of the nutraceutical enzymatic docosahexaenoic acid triglyceride (BrudiPlus) in high concentrations on damaged sperm DNA of patients with idiopathic pathozoospermia. 40 patients with idiopathic pathozoospermia and the level of DNA fragmentation over the statutory value took part in this study. The following positive results were received: intake of BrudiPlus allowed decreasing sperm DNA damages and improving of antioxidant system of sperm. |
| first_indexed | 2024-04-10T03:53:52Z |
| format | Article |
| id | doaj.art-729c8b4409624d048e2a6fc52a5ac1f1 |
| institution | Directory Open Access Journal |
| issn | 2070-9781 |
| language | Russian |
| last_indexed | 2024-04-10T03:53:52Z |
| publishDate | 2015-08-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Андрология и генитальная хирургия |
| spelling | doaj.art-729c8b4409624d048e2a6fc52a5ac1f12023-03-13T07:15:07ZrusABV-pressАндрология и генитальная хирургия2070-97812015-08-01162515510.17650/2070-9781-2015-16-2-51-55140Experience in the use of docosahexaenoic acid (BrudiPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and PerinatologyA. Yu. Popova0S. I. Gamidov1R. I. Ovchinnikov2I. V. Ushakova3O. N. Golubeva4Department of Urology and Andrology, Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia; 4 akademika Oparina St., Moscow, 117997, Russia; Department of Obstetrics, Gynecology, Perinatology and Reproductology, Faculty of Postgraduate Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; 4 akademika Oparina St., Moscow, 117997, RussiaDepartment of Urology and Andrology, Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia; 4 akademika Oparina St., Moscow, 117997, Russia; Department of Obstetrics, Gynecology, Perinatology and Reproductology, Faculty of Postgraduate Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; 4 akademika Oparina St., Moscow, 117997, RussiaDepartment of Urology and Andrology, Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia; 4 akademika Oparina St., Moscow, 117997, Russia;Department of Urology and Andrology, Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia; 4 akademika Oparina St., Moscow, 117997, Russia;Department of Urology and Andrology, Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia; 4 akademika Oparina St., Moscow, 117997, Russia;Male factor is the reason of infertility in almost half of marriages. Infertile men have the percentage of sperm with violations of DNA integrity of over 30 %; with that, healthy fertile men have that indicator of less than 15 %. Understanding of importance of damages of sperm DNA is growing with distribution ofauxiliary reproductive technologies. As of today, these consequences have not been studies yet, and the therapeutic effect of intake of antioxidants has not direct correlation with the sperm DNA fragmentation level. Docosahexaenoic acid is one of the most valuable omega-3 polyunsaturated fatty acids for human health. Docosahexaenoic acid is the main component of the brain gray matter, retina, testes, and sperm cell membranes. In connection with that, a study was held the purpose of which was to assess the effect of the nutraceutical enzymatic docosahexaenoic acid triglyceride (BrudiPlus) in high concentrations on damaged sperm DNA of patients with idiopathic pathozoospermia. 40 patients with idiopathic pathozoospermia and the level of DNA fragmentation over the statutory value took part in this study. The following positive results were received: intake of BrudiPlus allowed decreasing sperm DNA damages and improving of antioxidant system of sperm.https://agx.abvpress.ru/jour/article/view/146male infertilitysperm dna fragmentationdocosahexaenoic acidspermograminfertility treatmentfragmentation indexasthenozoospermiaasthenoteratozoospermiateratozoospermiaoligoasthenozoospermiaoligoasthenoteratozoospermia |
| spellingShingle | A. Yu. Popova S. I. Gamidov R. I. Ovchinnikov I. V. Ushakova O. N. Golubeva Experience in the use of docosahexaenoic acid (BrudiPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology Андрология и генитальная хирургия male infertility sperm dna fragmentation docosahexaenoic acid spermogram infertility treatment fragmentation index asthenozoospermia asthenoteratozoospermia teratozoospermia oligoasthenozoospermia oligoasthenoteratozoospermia |
| title | Experience in the use of docosahexaenoic acid (BrudiPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology |
| title_full | Experience in the use of docosahexaenoic acid (BrudiPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology |
| title_fullStr | Experience in the use of docosahexaenoic acid (BrudiPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology |
| title_full_unstemmed | Experience in the use of docosahexaenoic acid (BrudiPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology |
| title_short | Experience in the use of docosahexaenoic acid (BrudiPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology |
| title_sort | experience in the use of docosahexaenoic acid brudiplus in patients with increased sperm dna fragmentation index in acad v i kulakov research center for obstetrics gynecology and perinatology |
| topic | male infertility sperm dna fragmentation docosahexaenoic acid spermogram infertility treatment fragmentation index asthenozoospermia asthenoteratozoospermia teratozoospermia oligoasthenozoospermia oligoasthenoteratozoospermia |
| url | https://agx.abvpress.ru/jour/article/view/146 |
| work_keys_str_mv | AT ayupopova experienceintheuseofdocosahexaenoicacidbrudiplusinpatientswithincreasedspermdnafragmentationindexinacadvikulakovresearchcenterforobstetricsgynecologyandperinatology AT sigamidov experienceintheuseofdocosahexaenoicacidbrudiplusinpatientswithincreasedspermdnafragmentationindexinacadvikulakovresearchcenterforobstetricsgynecologyandperinatology AT riovchinnikov experienceintheuseofdocosahexaenoicacidbrudiplusinpatientswithincreasedspermdnafragmentationindexinacadvikulakovresearchcenterforobstetricsgynecologyandperinatology AT ivushakova experienceintheuseofdocosahexaenoicacidbrudiplusinpatientswithincreasedspermdnafragmentationindexinacadvikulakovresearchcenterforobstetricsgynecologyandperinatology AT ongolubeva experienceintheuseofdocosahexaenoicacidbrudiplusinpatientswithincreasedspermdnafragmentationindexinacadvikulakovresearchcenterforobstetricsgynecologyandperinatology |