Recombinant Human Erythropoietin Protects Myocardial Cells from Apoptosis via the Janus-Activated Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway in Rats with Epilepsy

Recombinant Human Erythropoietin Protects Myocardial Cells from Apoptosis via the Janus-Activated Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway in Rats with Epilepsy

Objective: To investigate the potential mechanisms underlying the protective effects of recombinant human erythropoietin (rhEPO) and carbamylated EPO (CEPO) against myocardial cell apoptosis in epilepsy. Methods: Rats were given an intra-amygdala injection of kainic acid to induce epilepsy. Groups o...

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Bibliographic Details
Main Authors: Bao-Xin Ma, MD, Jie Li, MD, Hua Li, MD, Sui-Sheng Wu, MD
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Current Therapeutic Research
Subjects:
apoptosis
epilepsy
erythropoietin
JAK2
STAT5
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X15000090

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