Individual differences in chemotherapy-induced anticipatory nausea

Anticipatory Nausea (AN) is a severe side effect of chemotherapy that can lead cancer patients to discontinue their treatment. This kind of nausea is usually elicited by the re-exposure of the patients to the clinical context they need to attend to be treated. There has been considerable agreement t...

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Main Author: Marcial eRodríguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Psychology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyg.2013.00502/full
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author Marcial eRodríguez
author_facet Marcial eRodríguez
author_sort Marcial eRodríguez
collection DOAJ
description Anticipatory Nausea (AN) is a severe side effect of chemotherapy that can lead cancer patients to discontinue their treatment. This kind of nausea is usually elicited by the re-exposure of the patients to the clinical context they need to attend to be treated. There has been considerable agreement that AN represents a paradigmatic example of Pavlovian conditioning, and within this framework, several behavioral interventions have been proposed in order to prevent this psychopathology. However, some studies have questioned the validity of the Pavlovian approach, suggesting that CS-US associations are neither necessary nor sufficient for AN to occur. The data and the alternative theories behind such criticisms are discussed. Additionally, it is suggested that animal models of AN could be enriched by taking into account rats’ individual differences.
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spelling doaj.art-729d13440c7743a6987eb1e29fddedac2022-12-21T22:55:24ZengFrontiers Media S.A.Frontiers in Psychology1664-10782013-08-01410.3389/fpsyg.2013.0050242880Individual differences in chemotherapy-induced anticipatory nauseaMarcial eRodríguez0University of GranadaAnticipatory Nausea (AN) is a severe side effect of chemotherapy that can lead cancer patients to discontinue their treatment. This kind of nausea is usually elicited by the re-exposure of the patients to the clinical context they need to attend to be treated. There has been considerable agreement that AN represents a paradigmatic example of Pavlovian conditioning, and within this framework, several behavioral interventions have been proposed in order to prevent this psychopathology. However, some studies have questioned the validity of the Pavlovian approach, suggesting that CS-US associations are neither necessary nor sufficient for AN to occur. The data and the alternative theories behind such criticisms are discussed. Additionally, it is suggested that animal models of AN could be enriched by taking into account rats’ individual differences.http://journal.frontiersin.org/Journal/10.3389/fpsyg.2013.00502/fullNauseaPersonalityRatschemotherapyClassical Conditioningdifferences
spellingShingle Marcial eRodríguez
Individual differences in chemotherapy-induced anticipatory nausea
Frontiers in Psychology
Nausea
Personality
Rats
chemotherapy
Classical Conditioning
differences
title Individual differences in chemotherapy-induced anticipatory nausea
title_full Individual differences in chemotherapy-induced anticipatory nausea
title_fullStr Individual differences in chemotherapy-induced anticipatory nausea
title_full_unstemmed Individual differences in chemotherapy-induced anticipatory nausea
title_short Individual differences in chemotherapy-induced anticipatory nausea
title_sort individual differences in chemotherapy induced anticipatory nausea
topic Nausea
Personality
Rats
chemotherapy
Classical Conditioning
differences
url http://journal.frontiersin.org/Journal/10.3389/fpsyg.2013.00502/full
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