Epigenetic mechanisms in metal carcinogenesis
Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic,...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750022000579 |
| _version_ | 1828121535475351552 |
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| author | Luka Manić David Wallace Pinar Uysal Onganer Yasmeen M. Taalab Ammad Ahmad Farooqi Biljana Antonijević Aleksandra Buha Djordjevic |
| author_facet | Luka Manić David Wallace Pinar Uysal Onganer Yasmeen M. Taalab Ammad Ahmad Farooqi Biljana Antonijević Aleksandra Buha Djordjevic |
| author_sort | Luka Manić |
| collection | DOAJ |
| description | Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure to carcinogenic metals and novel therapy development. |
| first_indexed | 2024-04-11T14:21:14Z |
| format | Article |
| id | doaj.art-729d2faeb0c54dbdbed93cdb447cd3ce |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-04-11T14:21:14Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-729d2faeb0c54dbdbed93cdb447cd3ce2022-12-22T04:19:03ZengElsevierToxicology Reports2214-75002022-01-019778787Epigenetic mechanisms in metal carcinogenesisLuka Manić0David Wallace1Pinar Uysal Onganer2Yasmeen M. Taalab3Ammad Ahmad Farooqi4Biljana Antonijević5Aleksandra Buha Djordjevic6Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, SerbiaSchool of Biomedical Science, Oklahoma State University Center for Health Sciences, Tulsa, United StatesCancer Research Group, School of Life Sciences, University of Westminster, London, UKInstitute of Forensic and Traffic Medicine, University of Heidelberg, Voßstraße 2, 69115 Heidelberg, Germany; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Dakahlia Governate 35516, EgyptLaboratory for Translational Oncology and Personalized Medicine, RLMC, Lahore, PakistanDepartment of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, SerbiaDepartment of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia; Correspondence to: Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure to carcinogenic metals and novel therapy development.http://www.sciencedirect.com/science/article/pii/S2214750022000579DNA methylationMicroRNAHistone modificationArsenicCadmiumChromium |
| spellingShingle | Luka Manić David Wallace Pinar Uysal Onganer Yasmeen M. Taalab Ammad Ahmad Farooqi Biljana Antonijević Aleksandra Buha Djordjevic Epigenetic mechanisms in metal carcinogenesis Toxicology Reports DNA methylation MicroRNA Histone modification Arsenic Cadmium Chromium |
| title | Epigenetic mechanisms in metal carcinogenesis |
| title_full | Epigenetic mechanisms in metal carcinogenesis |
| title_fullStr | Epigenetic mechanisms in metal carcinogenesis |
| title_full_unstemmed | Epigenetic mechanisms in metal carcinogenesis |
| title_short | Epigenetic mechanisms in metal carcinogenesis |
| title_sort | epigenetic mechanisms in metal carcinogenesis |
| topic | DNA methylation MicroRNA Histone modification Arsenic Cadmium Chromium |
| url | http://www.sciencedirect.com/science/article/pii/S2214750022000579 |
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