Eosinophilic bioactivities in severe asthma
Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | World Allergy Organization Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455119301772 |
| _version_ | 1818216109208240128 |
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| author | Tara F. Carr Sergejs Berdnikovs Hans-Uwe Simon Bruce S. Bochner Lanny J. Rosenwasser |
| author_facet | Tara F. Carr Sergejs Berdnikovs Hans-Uwe Simon Bruce S. Bochner Lanny J. Rosenwasser |
| author_sort | Tara F. Carr |
| collection | DOAJ |
| description | Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokines, cytokines, lipid mediators and other growth factors. Eosinophils may persist in the blood and airways despite guidelines-based treatment. This review details eosinophil effector mechanisms, surface markers, and clinical outcomes associated with eosinophilia and asthma severity. There is interest in the potential of eosinophils or their products to predict treatment response with biotherapeutics and their usefulness as biomarkers. This is important as monoclonal antibodies are targeting cytokines and eosinophils in different lung environments for treating severe asthma. Identifying disease state-specific eosinophil biomarkers would help to refine these strategies and choose likely responders to biotherapeutics. Keywords: Severe asthma, Eosinophils, Eosinophilia, Bioactivities, Biotherapeutics |
| first_indexed | 2024-12-12T06:46:45Z |
| format | Article |
| id | doaj.art-729d597ad94c4a4cb907026887a61872 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-12-12T06:46:45Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-729d597ad94c4a4cb907026887a618722022-12-22T00:34:10ZengElsevierWorld Allergy Organization Journal1939-45512016-01-019Eosinophilic bioactivities in severe asthmaTara F. Carr0Sergejs Berdnikovs1Hans-Uwe Simon2Bruce S. Bochner3Lanny J. Rosenwasser4University of Arizona, Tucson, Arizona, USANorthwestern University Feinberg School of Medicine, Chicago, Illinois, USAInstitute of Pharmacology, University of Bern, Bern, SwitzerlandNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USAChildren’s Mercy Hospital, Kansas City, Missouri, USA; Correspondence:Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokines, cytokines, lipid mediators and other growth factors. Eosinophils may persist in the blood and airways despite guidelines-based treatment. This review details eosinophil effector mechanisms, surface markers, and clinical outcomes associated with eosinophilia and asthma severity. There is interest in the potential of eosinophils or their products to predict treatment response with biotherapeutics and their usefulness as biomarkers. This is important as monoclonal antibodies are targeting cytokines and eosinophils in different lung environments for treating severe asthma. Identifying disease state-specific eosinophil biomarkers would help to refine these strategies and choose likely responders to biotherapeutics. Keywords: Severe asthma, Eosinophils, Eosinophilia, Bioactivities, Biotherapeuticshttp://www.sciencedirect.com/science/article/pii/S1939455119301772 |
| spellingShingle | Tara F. Carr Sergejs Berdnikovs Hans-Uwe Simon Bruce S. Bochner Lanny J. Rosenwasser Eosinophilic bioactivities in severe asthma World Allergy Organization Journal |
| title | Eosinophilic bioactivities in severe asthma |
| title_full | Eosinophilic bioactivities in severe asthma |
| title_fullStr | Eosinophilic bioactivities in severe asthma |
| title_full_unstemmed | Eosinophilic bioactivities in severe asthma |
| title_short | Eosinophilic bioactivities in severe asthma |
| title_sort | eosinophilic bioactivities in severe asthma |
| url | http://www.sciencedirect.com/science/article/pii/S1939455119301772 |
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