Carcinoma -associated Retinopathy(CAR): Role of Electroretinography(ERG) and Optical coherence Tomography(OCT) in diagnosis and predicting treatment outcome
Purpose: Cancer-associated retinopathy (CAR) is a potentially blinding condition that can be stalled or,rarely, reversed if diagnosed early. This case report aims to highlight the role of Electroretinography (ERG) and Optical Coherence Tomography (OCT) in diagnosis and predicting treatment response,...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993620303236 |
| _version_ | 1819053431290068992 |
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| author | R. Neena Aarti Jain Giridhar Anantharaman Michelle Aline Antony |
| author_facet | R. Neena Aarti Jain Giridhar Anantharaman Michelle Aline Antony |
| author_sort | R. Neena |
| collection | DOAJ |
| description | Purpose: Cancer-associated retinopathy (CAR) is a potentially blinding condition that can be stalled or,rarely, reversed if diagnosed early. This case report aims to highlight the role of Electroretinography (ERG) and Optical Coherence Tomography (OCT) in diagnosis and predicting treatment response, in the clinical scenario of unexplained vision loss in a patient with a recent diagnosis of uterine malignancy. Observations: A 70 year old lady, recently diagnosed with Endometrial carcinoma Stage 3, came to us with defective vision and photopsiae of both eyes of ten days duration. A high index of suspicion, flat ERG, OCT changes, absence of metastasis, and positive Antirecoverin antibody clinched the diagnosis. Early systemic steroid therapy along with surgical removal of the tumour, adjuvant radiotherapy and chemotherapy helped in visual improvement in our patient. Conclusions: Presence of intact ellipsoid zone (EZ) and external limiting membrane (ELM) in pre-treatment OCT was found to be a positive predictor of visual recovery. |
| first_indexed | 2024-12-21T12:35:37Z |
| format | Article |
| id | doaj.art-729d5c8e093a45429a819baf037471ca |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-21T12:35:37Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-729d5c8e093a45429a819baf037471ca2022-12-21T19:03:56ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362021-03-0121101008Carcinoma -associated Retinopathy(CAR): Role of Electroretinography(ERG) and Optical coherence Tomography(OCT) in diagnosis and predicting treatment outcomeR. Neena0Aarti Jain1Giridhar Anantharaman2Michelle Aline Antony3Giridhar Eye Institute, Ponneth Temple Road, Kadavanthara, Kochi, Kerala, 682020, India; Corresponding author.Giridhar Eye Institute, Ponneth Temple Road, Kadavanthara, Kochi, Kerala, 682020, IndiaGiridhar Eye Institute, Ponneth Temple Road, Kadavanthara, Kochi, Kerala, 682020, IndiaRajagiri Hospital, Near GTN Junction, Chunangamvely Aluva, Kochi, Kerala, 683112, IndiaPurpose: Cancer-associated retinopathy (CAR) is a potentially blinding condition that can be stalled or,rarely, reversed if diagnosed early. This case report aims to highlight the role of Electroretinography (ERG) and Optical Coherence Tomography (OCT) in diagnosis and predicting treatment response, in the clinical scenario of unexplained vision loss in a patient with a recent diagnosis of uterine malignancy. Observations: A 70 year old lady, recently diagnosed with Endometrial carcinoma Stage 3, came to us with defective vision and photopsiae of both eyes of ten days duration. A high index of suspicion, flat ERG, OCT changes, absence of metastasis, and positive Antirecoverin antibody clinched the diagnosis. Early systemic steroid therapy along with surgical removal of the tumour, adjuvant radiotherapy and chemotherapy helped in visual improvement in our patient. Conclusions: Presence of intact ellipsoid zone (EZ) and external limiting membrane (ELM) in pre-treatment OCT was found to be a positive predictor of visual recovery.http://www.sciencedirect.com/science/article/pii/S2451993620303236Cancer-associated retinopathy(CAR)Electroretinography(ERG)Optical coherence tomography(OCT)Fundus auto fluorescence(FAF)Ellipsoid zone(EZ)External limiting membrane(ELM) |
| spellingShingle | R. Neena Aarti Jain Giridhar Anantharaman Michelle Aline Antony Carcinoma -associated Retinopathy(CAR): Role of Electroretinography(ERG) and Optical coherence Tomography(OCT) in diagnosis and predicting treatment outcome American Journal of Ophthalmology Case Reports Cancer-associated retinopathy(CAR) Electroretinography(ERG) Optical coherence tomography(OCT) Fundus auto fluorescence(FAF) Ellipsoid zone(EZ) External limiting membrane(ELM) |
| title | Carcinoma -associated Retinopathy(CAR): Role of Electroretinography(ERG) and Optical coherence Tomography(OCT) in diagnosis and predicting treatment outcome |
| title_full | Carcinoma -associated Retinopathy(CAR): Role of Electroretinography(ERG) and Optical coherence Tomography(OCT) in diagnosis and predicting treatment outcome |
| title_fullStr | Carcinoma -associated Retinopathy(CAR): Role of Electroretinography(ERG) and Optical coherence Tomography(OCT) in diagnosis and predicting treatment outcome |
| title_full_unstemmed | Carcinoma -associated Retinopathy(CAR): Role of Electroretinography(ERG) and Optical coherence Tomography(OCT) in diagnosis and predicting treatment outcome |
| title_short | Carcinoma -associated Retinopathy(CAR): Role of Electroretinography(ERG) and Optical coherence Tomography(OCT) in diagnosis and predicting treatment outcome |
| title_sort | carcinoma associated retinopathy car role of electroretinography erg and optical coherence tomography oct in diagnosis and predicting treatment outcome |
| topic | Cancer-associated retinopathy(CAR) Electroretinography(ERG) Optical coherence tomography(OCT) Fundus auto fluorescence(FAF) Ellipsoid zone(EZ) External limiting membrane(ELM) |
| url | http://www.sciencedirect.com/science/article/pii/S2451993620303236 |
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