Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting
Self-propelled nanomotors have shown enormous potential in biomedical applications. Herein, we report on a nanozyme-powered cup-shaped nanomotor for active cellular targeting and synergistic photodynamic/thermal therapy under near-infrared (NIR) laser irradiation. The nanomotor is constructed by the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2022-01-01
|
| Series: | Research |
| Online Access: | http://dx.doi.org/10.34133/2022/9831012 |
| _version_ | 1797286692377329664 |
|---|---|
| author | Xin Wang Zhongju Ye Shen Lin Lin Wei Lehui Xiao |
| author_facet | Xin Wang Zhongju Ye Shen Lin Lin Wei Lehui Xiao |
| author_sort | Xin Wang |
| collection | DOAJ |
| description | Self-propelled nanomotors have shown enormous potential in biomedical applications. Herein, we report on a nanozyme-powered cup-shaped nanomotor for active cellular targeting and synergistic photodynamic/thermal therapy under near-infrared (NIR) laser irradiation. The nanomotor is constructed by the asymmetric decoration of platinum nanoparticles (PtNPs) at the bottom of gold nanocups (GNCs). PtNPs with robust peroxidase- (POD-) like activity are employed not only as propelling elements for nanomotors but also as continuous O2 generators to promote photodynamic therapy via catalyzing endogenous H2O2 decomposition. Owing to the Janus structure, asymmetric propulsion force is generated to trigger the short-ranged directional diffusion, facilitating broader diffusion areas and more efficient cellular searching and uptake. This cascade strategy combines key capabilities, i.e., endogenous substrate-based self-propulsion, active cellular targeting, and enhanced dual-modal therapy, in one multifunctional nanomotor, which is crucial in advancing self-propelled nanomotors towards eventual therapeutic agents. |
| first_indexed | 2024-03-07T18:21:56Z |
| format | Article |
| id | doaj.art-729da0f11c9a4aadbb9034ceba6ca8b0 |
| institution | Directory Open Access Journal |
| issn | 2639-5274 |
| language | English |
| last_indexed | 2024-03-07T18:21:56Z |
| publishDate | 2022-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj.art-729da0f11c9a4aadbb9034ceba6ca8b02024-03-02T07:13:28ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742022-01-01202210.34133/2022/9831012Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular TargetingXin Wang0Zhongju Ye1Shen Lin2Lin Wei3Lehui Xiao4State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, ChinaCollege of Chemistry, Zhengzhou University, Zhengzhou 450001, ChinaState Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, ChinaKey Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Key Laboratory of Phytochemical R&D of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410082, ChinaState Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, ChinaSelf-propelled nanomotors have shown enormous potential in biomedical applications. Herein, we report on a nanozyme-powered cup-shaped nanomotor for active cellular targeting and synergistic photodynamic/thermal therapy under near-infrared (NIR) laser irradiation. The nanomotor is constructed by the asymmetric decoration of platinum nanoparticles (PtNPs) at the bottom of gold nanocups (GNCs). PtNPs with robust peroxidase- (POD-) like activity are employed not only as propelling elements for nanomotors but also as continuous O2 generators to promote photodynamic therapy via catalyzing endogenous H2O2 decomposition. Owing to the Janus structure, asymmetric propulsion force is generated to trigger the short-ranged directional diffusion, facilitating broader diffusion areas and more efficient cellular searching and uptake. This cascade strategy combines key capabilities, i.e., endogenous substrate-based self-propulsion, active cellular targeting, and enhanced dual-modal therapy, in one multifunctional nanomotor, which is crucial in advancing self-propelled nanomotors towards eventual therapeutic agents.http://dx.doi.org/10.34133/2022/9831012 |
| spellingShingle | Xin Wang Zhongju Ye Shen Lin Lin Wei Lehui Xiao Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting Research |
| title | Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting |
| title_full | Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting |
| title_fullStr | Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting |
| title_full_unstemmed | Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting |
| title_short | Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting |
| title_sort | nanozyme triggered cascade reactions from cup shaped nanomotors promote active cellular targeting |
| url | http://dx.doi.org/10.34133/2022/9831012 |
| work_keys_str_mv | AT xinwang nanozymetriggeredcascadereactionsfromcupshapednanomotorspromoteactivecellulartargeting AT zhongjuye nanozymetriggeredcascadereactionsfromcupshapednanomotorspromoteactivecellulartargeting AT shenlin nanozymetriggeredcascadereactionsfromcupshapednanomotorspromoteactivecellulartargeting AT linwei nanozymetriggeredcascadereactionsfromcupshapednanomotorspromoteactivecellulartargeting AT lehuixiao nanozymetriggeredcascadereactionsfromcupshapednanomotorspromoteactivecellulartargeting |