Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction

Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction

Elevated glucagon level in obesity and diabetes promotes hepatic glucose production and hyperglycemia. Here the authors report that NF-κB2 augments the hepatic glucagon responses by inhibiting PDE4B induction, and that metformin lowers blood glucose in part by inhibiting NF-κB2.

Bibliographic Details
Main Authors:	Wen-Song Zhang, An Pan, Xu Zhang, Ang Ying, Gaoxiang Ma, Bao-Lin Liu, Lian-Wen Qi, Qun Liu, Ping Li
Format:	Article
Language:	English
Published:	Nature Portfolio 2019-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-12351-x

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