Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancer
Abstract Purpose This study aimed to compare the outcomes of patients with ground-grass opacity (GGO)-dominant non-small cell lung cancer (NSCLC) who were treated with carbon ion radiotherapy (CIRT) versus segmentectomy. Methods A retrospective review of medical records was conducted. The study incl...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13014-023-02387-1 |
| _version_ | 1827399400645722112 |
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| author | Teruaki Mizobuchi Akihiro Nomoto Hironobu Wada Naoyoshi Yamamoto Mio Nakajima Takehiko Fujisawa Hidemi Suzuki Ichiro Yoshino |
| author_facet | Teruaki Mizobuchi Akihiro Nomoto Hironobu Wada Naoyoshi Yamamoto Mio Nakajima Takehiko Fujisawa Hidemi Suzuki Ichiro Yoshino |
| author_sort | Teruaki Mizobuchi |
| collection | DOAJ |
| description | Abstract Purpose This study aimed to compare the outcomes of patients with ground-grass opacity (GGO)-dominant non-small cell lung cancer (NSCLC) who were treated with carbon ion radiotherapy (CIRT) versus segmentectomy. Methods A retrospective review of medical records was conducted. The study included 123 cases of clinical stage 0/IA peripheral NSCLC treated with single-fraction CIRT from 2003 to 2012, 14 of which were determined to be GGO-dominant and were assigned to CIRT group. As a control, 48 consecutive patients who underwent segmentectomy for peripheral GGO-dominant clinical stage IA NSCLC were assigned to segmentectomy group. Results The patients in CIRT group, compared with segmentectomy group, were significantly older (75 ± 7.2 vs. 65 ± 8.2 years, P = 0.000660), more likely to be male (13/14 vs. 22/48, P = 0.00179), and had a lower forced vital capacity (91 ± 19% vs. 110 ± 13%, P = 0.0173). There was a significant difference in the 5-years overall survival rate (86% vs. 96%, P = 0.000860), but not in the 5-years disease-specific survival rate (93% vs. 98%, P = 0.368). Discussion Compared with segmentectomy, CIRT may be an alternative option for patients with early GGO-dominant NSCLC who are poor candidates for, or who refuse, surgery. |
| first_indexed | 2024-03-08T19:44:27Z |
| format | Article |
| id | doaj.art-729fc7024fad4b3caf9708bb2ea40c61 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-03-08T19:44:27Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-729fc7024fad4b3caf9708bb2ea40c612023-12-24T12:25:29ZengBMCRadiation Oncology1748-717X2023-12-011811810.1186/s13014-023-02387-1Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancerTeruaki Mizobuchi0Akihiro Nomoto1Hironobu Wada2Naoyoshi Yamamoto3Mio Nakajima4Takehiko Fujisawa5Hidemi Suzuki6Ichiro Yoshino7Department of General Thoracic Surgery, Social Welfare Organization Saiseikai Imperial Gift Foundation, Chibaken Saiseikai Narashino HospitalDepartment of Radiology, Teikyo University School of MedicineDepartment of Pulmonary Surgery, International University of Health and Welfare Narita HospitalDepartment of Internal Medicine, Chosei Municipal HospitalNational Institutes for Quantum Science and Technology QST HospitalChiba Foundation for Health Promotion and Disease PreventionDepartments of General Thoracic Surgery, Departments of General Thoracic Surgery, Graduate School of Medicine, Chiba UniversityDepartments of General Thoracic Surgery, Departments of General Thoracic Surgery, Graduate School of Medicine, Chiba UniversityAbstract Purpose This study aimed to compare the outcomes of patients with ground-grass opacity (GGO)-dominant non-small cell lung cancer (NSCLC) who were treated with carbon ion radiotherapy (CIRT) versus segmentectomy. Methods A retrospective review of medical records was conducted. The study included 123 cases of clinical stage 0/IA peripheral NSCLC treated with single-fraction CIRT from 2003 to 2012, 14 of which were determined to be GGO-dominant and were assigned to CIRT group. As a control, 48 consecutive patients who underwent segmentectomy for peripheral GGO-dominant clinical stage IA NSCLC were assigned to segmentectomy group. Results The patients in CIRT group, compared with segmentectomy group, were significantly older (75 ± 7.2 vs. 65 ± 8.2 years, P = 0.000660), more likely to be male (13/14 vs. 22/48, P = 0.00179), and had a lower forced vital capacity (91 ± 19% vs. 110 ± 13%, P = 0.0173). There was a significant difference in the 5-years overall survival rate (86% vs. 96%, P = 0.000860), but not in the 5-years disease-specific survival rate (93% vs. 98%, P = 0.368). Discussion Compared with segmentectomy, CIRT may be an alternative option for patients with early GGO-dominant NSCLC who are poor candidates for, or who refuse, surgery.https://doi.org/10.1186/s13014-023-02387-1Lung cancerCarbon ion radiotherapySegmentectomyGround glass opacity |
| spellingShingle | Teruaki Mizobuchi Akihiro Nomoto Hironobu Wada Naoyoshi Yamamoto Mio Nakajima Takehiko Fujisawa Hidemi Suzuki Ichiro Yoshino Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancer Radiation Oncology Lung cancer Carbon ion radiotherapy Segmentectomy Ground glass opacity |
| title | Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancer |
| title_full | Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancer |
| title_fullStr | Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancer |
| title_full_unstemmed | Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancer |
| title_short | Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancer |
| title_sort | outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity dominant early stage lung cancer |
| topic | Lung cancer Carbon ion radiotherapy Segmentectomy Ground glass opacity |
| url | https://doi.org/10.1186/s13014-023-02387-1 |
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