Folate deficiency elimination: basic strategy homocysteine dependent correction of endothelial dysfunction
Endothelial dysfunction is one of the most important pathogenetic mechanisms of both cardiovascular disease and uterine-placental microcirculation. Recent research shows that homocysteine plays a role of a forthcoming universal pathogenic factor in the case of mechanisms regulating cellular homeosta...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IP Berlin A.V.
2013-06-01
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| Series: | Гинекология |
| Subjects: | |
| Online Access: | https://gynecology.orscience.ru/2079-5831/article/view/28247 |
| _version_ | 1818472418809741312 |
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| author | N I Tapilskaya S N Gaidukov |
| author_facet | N I Tapilskaya S N Gaidukov |
| author_sort | N I Tapilskaya |
| collection | DOAJ |
| description | Endothelial dysfunction is one of the most important pathogenetic mechanisms of both cardiovascular disease and uterine-placental microcirculation. Recent research shows that homocysteine plays a role of a forthcoming universal pathogenic factor in the case of mechanisms regulating cellular homeostasis depletion, namely, in a long flowing hyperhomocysteinemia by an imbalance in the antioxidant system of the body leads to a decrease in the number of endothelial progenitor cells, which reduces the regenerative capacity and plasticity of the vascular wall. Hyperhomocysteine when administered in excessive concentrations leads to inhibition of sodium-potassium adenosinetriphosphatase in the membrane of vascular smooth muscle cells, increasing intracellular sodium concentration, and thus leading to electrolyte disturbances that cause vasoconstriction becoming and essential element is a vicious circle of the underlying pathogenesis of both hypertension and preeclampsia. The use of contraceptives containing biologically active folate metafolin on preconception stage is a part of a targeted approach to the prevention of complications of pregnancy in women of reproductive age. |
| first_indexed | 2024-04-14T04:07:25Z |
| format | Article |
| id | doaj.art-72a2c5417cb547579e37001c0d7fc279 |
| institution | Directory Open Access Journal |
| issn | 2079-5696 2079-5831 |
| language | Russian |
| last_indexed | 2024-04-14T04:07:25Z |
| publishDate | 2013-06-01 |
| publisher | IP Berlin A.V. |
| record_format | Article |
| series | Гинекология |
| spelling | doaj.art-72a2c5417cb547579e37001c0d7fc2792022-12-22T02:13:19ZrusIP Berlin A.V.Гинекология2079-56962079-58312013-06-01153707425377Folate deficiency elimination: basic strategy homocysteine dependent correction of endothelial dysfunctionN I TapilskayaS N GaidukovEndothelial dysfunction is one of the most important pathogenetic mechanisms of both cardiovascular disease and uterine-placental microcirculation. Recent research shows that homocysteine plays a role of a forthcoming universal pathogenic factor in the case of mechanisms regulating cellular homeostasis depletion, namely, in a long flowing hyperhomocysteinemia by an imbalance in the antioxidant system of the body leads to a decrease in the number of endothelial progenitor cells, which reduces the regenerative capacity and plasticity of the vascular wall. Hyperhomocysteine when administered in excessive concentrations leads to inhibition of sodium-potassium adenosinetriphosphatase in the membrane of vascular smooth muscle cells, increasing intracellular sodium concentration, and thus leading to electrolyte disturbances that cause vasoconstriction becoming and essential element is a vicious circle of the underlying pathogenesis of both hypertension and preeclampsia. The use of contraceptives containing biologically active folate metafolin on preconception stage is a part of a targeted approach to the prevention of complications of pregnancy in women of reproductive age.https://gynecology.orscience.ru/2079-5831/article/view/28247homocysteineendothelial dysfunctionmetafolincombined oral contraceptives, folate containing |
| spellingShingle | N I Tapilskaya S N Gaidukov Folate deficiency elimination: basic strategy homocysteine dependent correction of endothelial dysfunction Гинекология homocysteine endothelial dysfunction metafolin combined oral contraceptives, folate containing |
| title | Folate deficiency elimination: basic strategy homocysteine dependent correction of endothelial dysfunction |
| title_full | Folate deficiency elimination: basic strategy homocysteine dependent correction of endothelial dysfunction |
| title_fullStr | Folate deficiency elimination: basic strategy homocysteine dependent correction of endothelial dysfunction |
| title_full_unstemmed | Folate deficiency elimination: basic strategy homocysteine dependent correction of endothelial dysfunction |
| title_short | Folate deficiency elimination: basic strategy homocysteine dependent correction of endothelial dysfunction |
| title_sort | folate deficiency elimination basic strategy homocysteine dependent correction of endothelial dysfunction |
| topic | homocysteine endothelial dysfunction metafolin combined oral contraceptives, folate containing |
| url | https://gynecology.orscience.ru/2079-5831/article/view/28247 |
| work_keys_str_mv | AT nitapilskaya folatedeficiencyeliminationbasicstrategyhomocysteinedependentcorrectionofendothelialdysfunction AT sngaidukov folatedeficiencyeliminationbasicstrategyhomocysteinedependentcorrectionofendothelialdysfunction |