Drug-induced regulation of target expression.

Drug-induced regulation of target expression.

Drug perturbations of human cells lead to complex responses upon target binding. One of the known mechanisms is a (positive or negative) feedback loop that adjusts the expression level of the respective target protein. To quantify this mechanism systems-wide in an unbiased way, drug-induced differen...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Murat Iskar, Monica Campillos, Michael Kuhn, Lars Juhl Jensen, Vera van Noort, Peer Bork
Natura:	Articolo
Lingua:	English
Pubblicazione:	Public Library of Science (PLoS) 2010-09-01
Serie:	PLoS Computational Biology
Accesso online:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20838579/pdf/?tool=EBI

Documenti analoghi

Network neighbors of drug targets contribute to drug side-effect similarity.
di: Lucas Brouwers, et al.
Pubblicazione: (2011-01-01)

Prediction of drug combinations by integrating molecular and pharmacological data.
di: Xing-Ming Zhao, et al.
Pubblicazione: (2011-12-01)

Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding
di: Murat Iskar, et al.
Pubblicazione: (2013-04-01)

A side effect resource to capture phenotypic effects of drugs
di: Michael Kuhn, et al.
Pubblicazione: (2010-01-01)

Systematic identification of proteins that elicit drug side effects
di: Michael Kuhn, et al.
Pubblicazione: (2013-04-01)

Sejarah perkembangan pembinaan masjid al-Ikhlas, Bandar Selesa Jaya di Johor Bahru /
di: 442642 Khalilah Kamaruddin Iskar
Pubblicazione: (2008)

Academic Cheating in Pesantren: How Self Efficacy, Religiosity, and Academic Integrity Predict Academic Cheating
di: Wahidah Iskar Lestari, et al.
Pubblicazione: (2022-11-01)

LOCAL COMMUNITY’S ECOLOGICAL KNOWLEDGE IN THE SELECTION OF SHADING TREESFOR TRADITIONAL AGROFORESTRY SYSTEM (NUTMEG “DUSUNG”) IN AMBON
di: Messalina Lovenia Salampessy, et al.
Pubblicazione: (2017-04-01)

Cell type‐specific nuclear pores: a case in point for context‐dependent stoichiometry of molecular machines
di: Alessandro Ori, et al.
Pubblicazione: (2013-03-01)

Toward molecular trait‐based ecology through integration of biogeochemical, geographical and metagenomic data
di: Jeroen Raes, et al.
Pubblicazione: (2011-03-01)

Annotation of the M. tuberculosis hypothetical orfeome: adding functional information to more than half of the uncharacterized proteins.
di: Tobias Doerks, et al.
Pubblicazione: (2012-01-01)

Evolution and functional cross‐talk of protein post‐translational modifications
di: Pedro Beltrao, et al.
Pubblicazione: (2013-12-01)

Rekabentuk masjid hip hop /
di: 442642 Khalilah Kamaruddin Iskar, et al.
Pubblicazione: (2009)

Comments on "Human dominant disease genes are enriched in paralogs originating from whole genome duplication".
di: Wei-Hua Chen, et al.
Pubblicazione: (2014-07-01)

Ontologies in quantitative biology: a basis for comparison, integration, and discovery.
di: Lars J Jensen, et al.
Pubblicazione: (2010-05-01)

NetworKIN: a resource for exploring cellular phosphorylation networks
di: Jensen, Lars Juhl, et al.
Pubblicazione: (2012)

A Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug Effects.
di: Jeanette Prinz, et al.
Pubblicazione: (2016-09-01)

Streamlined analysis of drug targets by proteome integral solubility alteration indicates organ-specific engagement
di: Tanveer Singh Batth, et al.
Pubblicazione: (2024-10-01)

Extraction of transcript diversity from scientific literature.
di: Parantu K Shah, et al.
Pubblicazione: (2005-06-01)

Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions
di: Maria Claudia Costa, et al.
Pubblicazione: (2024-03-01)

Structural genomics of human proteins – target selection and generation of a public catalogue of expression clones
di: Harttig Ulrich, et al.
Pubblicazione: (2005-07-01)

Transcriptional regulation is a major controller of cell cycle transition dynamics.
di: Alessandro Romanel, et al.
Pubblicazione: (2012-01-01)

Deciphering a global network of functionally associated post‐translational modifications
di: Pablo Minguez, et al.
Pubblicazione: (2012-07-01)

Drug target ontology to classify and integrate drug discovery data
di: Yu Lin, et al.
Pubblicazione: (2017-11-01)

Design, implementation, and operation of a rapid, robust named entity recognition web service
di: Sune Pletscher-Frankild, et al.
Pubblicazione: (2019-03-01)

Assessment of Drug-Induced Toxicity Biomarkers in the Brain Microphysiological System (MPS) Using Targeted and Untargeted Molecular Profiling
di: Mina, Sara G., et al.
Pubblicazione: (2020)

Bradykinin-Mediated Angioedema Induced by Commonly Used Cardiovascular Drugs
di: Janina Hahn, et al.
Pubblicazione: (2023-09-01)

Light-induced asymmetries in embryonic retinal gene expression are mediated by the vascular system and extracellular matrix
di: Elisabetta Versace, et al.
Pubblicazione: (2022-07-01)

Consistent mutational paths predict eukaryotic thermostability
di: van Noort Vera, et al.
Pubblicazione: (2013-01-01)

Mining Drug-Target Associations in Cancer: Analysis of Gene Expression and Drug Activity Correlations
di: Monica M. Arroyo, et al.
Pubblicazione: (2020-04-01)

Processing overwhelms biostimulant‐induced vitamin E improvement in lentils
di: Sílvia Campillos, et al.
Pubblicazione: (2023-09-01)

Comprehensive comparison of large-scale tissue expression datasets
di: Alberto Santos, et al.
Pubblicazione: (2015-06-01)

DoReMi: context-based prioritization of linear motif matches
di: Heiko Horn, et al.
Pubblicazione: (2014-03-01)

Análisis de errores pragmático-discursivos en un corpus oral de lengua española
di: Leonardo Campillos
Pubblicazione: (2014-06-01)

The application of tetracycline-regulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis
di: Joanna Catherine Evans, et al.
Pubblicazione: (2015-08-01)

Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease
di: Reza Yarani, et al.
Pubblicazione: (2022-06-01)

Assessing systems properties of yeast mitochondria through an interaction map of the organelle.
di: Fabiana Perocchi, et al.
Pubblicazione: (2006-10-01)

Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression
di: Edward Pym, et al.
Pubblicazione: (2017-05-01)

Feedback regulation in gene networks
di: Acar, Murat
Pubblicazione: (2009)

Targeted Regulation Of Cgrp Gene Expression
di: A. F. Russo, et al.
Pubblicazione: (2001-01-01)