Antibody persistence in pre-school children after hexavalent vaccine infant primary and booster administration
Objective: Antibody persistence evaluation for all antigens of a fully liquid DTaP-IPV-HB-PRP~T vaccine at 3.5 and 4.5 y of age following different primary series and booster schedules in South Africa and Latin America. Methods: Participants had completed one of two previous studies (Study 1-South A...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-03-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1546524 |
| _version_ | 1827809783318577152 |
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| author | Shabir A. Madhi Pío López Betzana Zambrano Emilia Jordanov Siham B’Chir Fernando Noriega Emmanuel Feroldi |
| author_facet | Shabir A. Madhi Pío López Betzana Zambrano Emilia Jordanov Siham B’Chir Fernando Noriega Emmanuel Feroldi |
| author_sort | Shabir A. Madhi |
| collection | DOAJ |
| description | Objective: Antibody persistence evaluation for all antigens of a fully liquid DTaP-IPV-HB-PRP~T vaccine at 3.5 and 4.5 y of age following different primary series and booster schedules in South Africa and Latin America. Methods: Participants had completed one of two previous studies (Study 1-South Africa; Study 2-Latin America). In Study 1, participants who had not received HB vaccine at birth received a 6–10-14 week primary series of DTaP-IPV-HB-PRP~T or DTwP/PRP~T-Hib+HB+OPV and a third group who had received HB vaccine at birth received a 6–10-14 week primary series of DTaP-IPV-HB-PRP~T; all received a booster (15–18 months) of the primary series vaccine(s) except for HB in the DTwP/PRP~T-Hib group. In Study 2, participants received HB vaccine at birth, a 2–4-6 month primary series of DTaP-IPV-HB-PRP~T or DTaP-HB-IPV//PRP~T, and a DTaP-IPV-HB-PRP~T or DTaP-HB-IPV//PRP~T booster (12–24 months). Participants were followed up at 3.5 and 4.5 y of age for antibody persistence. Results: Approximately 80% of eligible participants were assessed. In Study 1, a birth dose of HB increased anti-HBs persistence (≥10 mIU/mL) following DTaP-IPV-HB-PRP~T primary and booster vaccination from 76.3% to 96.1% at 3.5 y of age and from 73.3% to 96.1% at 4.5 y of age; in Study 2, anti-HBs persistence was high and similar in each group. For the other antigens, there were no differences between groups or studies at 3.5 or 4.5 y. Conclusion: Good persistence of antibodies to each antigen in the DTaP-IPV-HB-PRP~T vaccine up to pre-school age, irrespective of the vaccination schedule during the first 2 y of life. |
| first_indexed | 2024-03-11T22:44:53Z |
| format | Article |
| id | doaj.art-72a4084b7ffa4c37a98eb077503572dd |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:44:53Z |
| publishDate | 2019-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-72a4084b7ffa4c37a98eb077503572dd2023-09-22T08:38:24ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2019-03-0115365866810.1080/21645515.2018.15465241546524Antibody persistence in pre-school children after hexavalent vaccine infant primary and booster administrationShabir A. Madhi0Pío López1Betzana Zambrano2Emilia Jordanov3Siham B’Chir4Fernando Noriega5Emmanuel Feroldi6University of the WitwatersrandCentro de Estudios en Infectología PediátricaSanofi PasteurSanofi PasteurSanofi PasteurSanofi PasteurSanofi PasteurObjective: Antibody persistence evaluation for all antigens of a fully liquid DTaP-IPV-HB-PRP~T vaccine at 3.5 and 4.5 y of age following different primary series and booster schedules in South Africa and Latin America. Methods: Participants had completed one of two previous studies (Study 1-South Africa; Study 2-Latin America). In Study 1, participants who had not received HB vaccine at birth received a 6–10-14 week primary series of DTaP-IPV-HB-PRP~T or DTwP/PRP~T-Hib+HB+OPV and a third group who had received HB vaccine at birth received a 6–10-14 week primary series of DTaP-IPV-HB-PRP~T; all received a booster (15–18 months) of the primary series vaccine(s) except for HB in the DTwP/PRP~T-Hib group. In Study 2, participants received HB vaccine at birth, a 2–4-6 month primary series of DTaP-IPV-HB-PRP~T or DTaP-HB-IPV//PRP~T, and a DTaP-IPV-HB-PRP~T or DTaP-HB-IPV//PRP~T booster (12–24 months). Participants were followed up at 3.5 and 4.5 y of age for antibody persistence. Results: Approximately 80% of eligible participants were assessed. In Study 1, a birth dose of HB increased anti-HBs persistence (≥10 mIU/mL) following DTaP-IPV-HB-PRP~T primary and booster vaccination from 76.3% to 96.1% at 3.5 y of age and from 73.3% to 96.1% at 4.5 y of age; in Study 2, anti-HBs persistence was high and similar in each group. For the other antigens, there were no differences between groups or studies at 3.5 or 4.5 y. Conclusion: Good persistence of antibodies to each antigen in the DTaP-IPV-HB-PRP~T vaccine up to pre-school age, irrespective of the vaccination schedule during the first 2 y of life.http://dx.doi.org/10.1080/21645515.2018.1546524fully liquidhexavalentimmunity persistenceinfantprimary seriesboostervaccine |
| spellingShingle | Shabir A. Madhi Pío López Betzana Zambrano Emilia Jordanov Siham B’Chir Fernando Noriega Emmanuel Feroldi Antibody persistence in pre-school children after hexavalent vaccine infant primary and booster administration Human Vaccines & Immunotherapeutics fully liquid hexavalent immunity persistence infant primary series booster vaccine |
| title | Antibody persistence in pre-school children after hexavalent vaccine infant primary and booster administration |
| title_full | Antibody persistence in pre-school children after hexavalent vaccine infant primary and booster administration |
| title_fullStr | Antibody persistence in pre-school children after hexavalent vaccine infant primary and booster administration |
| title_full_unstemmed | Antibody persistence in pre-school children after hexavalent vaccine infant primary and booster administration |
| title_short | Antibody persistence in pre-school children after hexavalent vaccine infant primary and booster administration |
| title_sort | antibody persistence in pre school children after hexavalent vaccine infant primary and booster administration |
| topic | fully liquid hexavalent immunity persistence infant primary series booster vaccine |
| url | http://dx.doi.org/10.1080/21645515.2018.1546524 |
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