GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages

GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages

Abstract Anemia is a significant complication of chronic inflammation and may be related to dysregulated activities among erythroblastic island (EBI) macrophages. GM-CSF was reported to be upregulated and attracted as a therapeutic target in many inflammatory diseases. Among EBIs, we found that the...

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Bibliographic Details
Main Authors: Weijie Cao, Wenjuan Fan, Fang Wang, Yinyin Zhang, Guanghua Wu, Xiaojing Shi, Jian xiang Shi, Fengcai Gao, Meimei Yan, Rong Guo, Yingmei Li, Wei Li, Chunyan Du, Zhongxing Jiang
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Translational Medicine
Subjects:
GMCSF
EBI macrophages
Erythropoiesis
Anemia of inflammatory diseases
Online Access:https://doi.org/10.1186/s12967-021-03214-5

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