Mixed phenotype acute leukemia: B/T-cell type-case report and review of literature
Mixed phenotypic acute leukemia (MPAL), classified under acute leukemia of ambiguous lineage, pose diagnostic dilemma due to multiple lineage-specific antigen expression. World Health Organization has laid down strict criteria for assigning >1 lineage to a single blast population. Most reported c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Journal of Applied Hematology |
| Subjects: | |
| Online Access: | http://www.jahjournal.org/article.asp?issn=1658-5127;year=2015;volume=6;issue=1;spage=27;epage=29;aulast=Sharma |
| _version_ | 1828974181110251520 |
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| author | Sunita Sharma Preeti Rai Richa Chauhan Jagdish Chandra |
| author_facet | Sunita Sharma Preeti Rai Richa Chauhan Jagdish Chandra |
| author_sort | Sunita Sharma |
| collection | DOAJ |
| description | Mixed phenotypic acute leukemia (MPAL), classified under acute leukemia of ambiguous lineage, pose diagnostic dilemma due to multiple lineage-specific antigen expression. World Health Organization has laid down strict criteria for assigning >1 lineage to a single blast population. Most reported cases of biphenotypic acute leukemia belong to myeloid/B-cell lineage or myeloid/T-cell lineage. However, MPAL with B-/T-cell phenotype is very rare. A 5-year-old girl was admitted with fever, petechial rash, pallor, generalized lymphadenopathy, and hepatosplenomegaly. Complete blood counts revealed leukocytosis, anemia, and thrombocytopenia. Bone Marrow Aspiration showed 97% blasts which were negative for myeloperoxidase, and nonspecific esterase. Immunophenotyping showed a single compact population of blasts which expressed CD19, CD79a, CD22, cytoplasmic CD3, and CD7. Thus, flow cytometric immunophenotyping helped to establish a final diagnosis of MPAL: B/T-cell type. |
| first_indexed | 2024-12-14T13:57:41Z |
| format | Article |
| id | doaj.art-72ac9f274d444d9ebb67f40e5a833880 |
| institution | Directory Open Access Journal |
| issn | 1658-5127 |
| language | English |
| last_indexed | 2024-12-14T13:57:41Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Applied Hematology |
| spelling | doaj.art-72ac9f274d444d9ebb67f40e5a8338802022-12-21T22:58:48ZengWolters Kluwer Medknow PublicationsJournal of Applied Hematology1658-51272015-01-0161272910.4103/1658-5127.155182Mixed phenotype acute leukemia: B/T-cell type-case report and review of literatureSunita SharmaPreeti RaiRicha ChauhanJagdish ChandraMixed phenotypic acute leukemia (MPAL), classified under acute leukemia of ambiguous lineage, pose diagnostic dilemma due to multiple lineage-specific antigen expression. World Health Organization has laid down strict criteria for assigning >1 lineage to a single blast population. Most reported cases of biphenotypic acute leukemia belong to myeloid/B-cell lineage or myeloid/T-cell lineage. However, MPAL with B-/T-cell phenotype is very rare. A 5-year-old girl was admitted with fever, petechial rash, pallor, generalized lymphadenopathy, and hepatosplenomegaly. Complete blood counts revealed leukocytosis, anemia, and thrombocytopenia. Bone Marrow Aspiration showed 97% blasts which were negative for myeloperoxidase, and nonspecific esterase. Immunophenotyping showed a single compact population of blasts which expressed CD19, CD79a, CD22, cytoplasmic CD3, and CD7. Thus, flow cytometric immunophenotyping helped to establish a final diagnosis of MPAL: B/T-cell type.http://www.jahjournal.org/article.asp?issn=1658-5127;year=2015;volume=6;issue=1;spage=27;epage=29;aulast=SharmaAcute leukemiaB/T subtypemixed phenotype |
| spellingShingle | Sunita Sharma Preeti Rai Richa Chauhan Jagdish Chandra Mixed phenotype acute leukemia: B/T-cell type-case report and review of literature Journal of Applied Hematology Acute leukemia B/T subtype mixed phenotype |
| title | Mixed phenotype acute leukemia: B/T-cell type-case report and review of literature |
| title_full | Mixed phenotype acute leukemia: B/T-cell type-case report and review of literature |
| title_fullStr | Mixed phenotype acute leukemia: B/T-cell type-case report and review of literature |
| title_full_unstemmed | Mixed phenotype acute leukemia: B/T-cell type-case report and review of literature |
| title_short | Mixed phenotype acute leukemia: B/T-cell type-case report and review of literature |
| title_sort | mixed phenotype acute leukemia b t cell type case report and review of literature |
| topic | Acute leukemia B/T subtype mixed phenotype |
| url | http://www.jahjournal.org/article.asp?issn=1658-5127;year=2015;volume=6;issue=1;spage=27;epage=29;aulast=Sharma |
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