Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons

In neurons, the microtubule cytoskeleton provides support and directionality of axons. Here, the authors report that microtubule dynamics in axons may be regulated by the autophagy proteins (ATGs) independently of their known role in autophagy.

Bibliographic Details
Main Authors: A. Negrete-Hurtado, M. Overhoff, S. Bera, E. De Bruyckere, K. Schätzmüller, M. J. Kye, C. Qin, M. Lammers, V. Kondylis, I. Neundorf, N. L. Kononenko
Format: Article
Language:English
Published: Nature Portfolio 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15287-9
Description
Summary:In neurons, the microtubule cytoskeleton provides support and directionality of axons. Here, the authors report that microtubule dynamics in axons may be regulated by the autophagy proteins (ATGs) independently of their known role in autophagy.
ISSN:2041-1723