Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the abs...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-04-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/16/4/130 |
| _version_ | 1798006738065031168 |
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| author | Dayoung Kim Eun Ju Lee Jihye Lee Alain S. Leutou Yern-Hyerk Shin Bomi Choi Ji Sun Hwang Dongyup Hahn Hyukjae Choi Jungwook Chin Sung Jin Cho Yong Deog Hong Jaeyoung Ko Chi Nam Seong Katherine N. Maloney Dong-Chan Oh Inho Yang Hayoung Hwang Sang-Jip Nam |
| author_facet | Dayoung Kim Eun Ju Lee Jihye Lee Alain S. Leutou Yern-Hyerk Shin Bomi Choi Ji Sun Hwang Dongyup Hahn Hyukjae Choi Jungwook Chin Sung Jin Cho Yong Deog Hong Jaeyoung Ko Chi Nam Seong Katherine N. Maloney Dong-Chan Oh Inho Yang Hayoung Hwang Sang-Jip Nam |
| author_sort | Dayoung Kim |
| collection | DOAJ |
| description | Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase. |
| first_indexed | 2024-04-11T13:00:30Z |
| format | Article |
| id | doaj.art-72b21dfdf2b14bcea07d24dd6575ff67 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T13:00:30Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-72b21dfdf2b14bcea07d24dd6575ff672022-12-22T04:22:58ZengMDPI AGMarine Drugs1660-33972018-04-0116413010.3390/md16040130md16040130Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine SedimentDayoung Kim0Eun Ju Lee1Jihye Lee2Alain S. Leutou3Yern-Hyerk Shin4Bomi Choi5Ji Sun Hwang6Dongyup Hahn7Hyukjae Choi8Jungwook Chin9Sung Jin Cho10Yong Deog Hong11Jaeyoung Ko12Chi Nam Seong13Katherine N. Maloney14Dong-Chan Oh15Inho Yang16Hayoung Hwang17Sang-Jip Nam18Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, KoreaNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, KoreaDepartment of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, KoreaDepartment of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, KoreaNatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 08826, KoreaDepartment of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, KoreaNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, KoreaSchool of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, KoreaCollege of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbukdo 38541, KoreaNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, KoreaNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, KoreaMaterials Lab Amorepacific R&D Unit, Yongin, Gyeonggi-do 17074, KoreaMaterials Lab Amorepacific R&D Unit, Yongin, Gyeonggi-do 17074, KoreaDepartment of Biology, College of Life Science and Natural Resource, Sunchon National University, Suncheon 57922, KoreaDepartment of Chemistry, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, CA 92106, USANatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 08826, KoreaDepartment of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, KoreaNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, KoreaDepartment of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, KoreaAntartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.http://www.mdpi.com/1660-3397/16/4/130Streptomyces sp.cold water natural productmarine natural productzizaane-type sesquiterpenoid |
| spellingShingle | Dayoung Kim Eun Ju Lee Jihye Lee Alain S. Leutou Yern-Hyerk Shin Bomi Choi Ji Sun Hwang Dongyup Hahn Hyukjae Choi Jungwook Chin Sung Jin Cho Yong Deog Hong Jaeyoung Ko Chi Nam Seong Katherine N. Maloney Dong-Chan Oh Inho Yang Hayoung Hwang Sang-Jip Nam Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment Marine Drugs Streptomyces sp. cold water natural product marine natural product zizaane-type sesquiterpenoid |
| title | Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment |
| title_full | Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment |
| title_fullStr | Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment |
| title_full_unstemmed | Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment |
| title_short | Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment |
| title_sort | antartin a cytotoxic zizaane type sesquiterpenoid from a streptomyces sp isolated from an antarctic marine sediment |
| topic | Streptomyces sp. cold water natural product marine natural product zizaane-type sesquiterpenoid |
| url | http://www.mdpi.com/1660-3397/16/4/130 |
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