Ideal body weight-based determination of minimum oral calories beneficial to function and survival in ALS
IntroductionThis study sought to identify the optimal caloric intake to improve function and survival in ALS patients by comparing oral intake per ideal body weight (IBW) and its discrepancy with total energy expenditure (TEE) using the Shimizu formula.MethodsA retrospective analysis of 104 ALS pati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1286153/full |
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| author | Ryutaro Nakamura Mika Kurihara Shuhei Kobashi Yoshitaka Tamaki Nobuhiro Ogawa Akihiro Kitamura Isamu Yamakawa Shigeki Bamba Shigeki Bamba Tomoya Terashima Makoto Urushitani |
| author_facet | Ryutaro Nakamura Mika Kurihara Shuhei Kobashi Yoshitaka Tamaki Nobuhiro Ogawa Akihiro Kitamura Isamu Yamakawa Shigeki Bamba Shigeki Bamba Tomoya Terashima Makoto Urushitani |
| author_sort | Ryutaro Nakamura |
| collection | DOAJ |
| description | IntroductionThis study sought to identify the optimal caloric intake to improve function and survival in ALS patients by comparing oral intake per ideal body weight (IBW) and its discrepancy with total energy expenditure (TEE) using the Shimizu formula.MethodsA retrospective analysis of 104 ALS patients was conducted, categorizing them based on their average intake during the first week after admission using two primary intake cutoffs: 25 kcal/kgIBW and 30 kcal/kgIBW. The variance between oral intake and TEE was also evaluated using −300 kcal and 0 kcal as reference points.ResultsOral caloric intake per IBW and functional decline rate (rs = −0.35, p < 0.001), but the variance from TEE was not significantly correlated (−0.11, p = 0.27). Survival data showed that patients consuming less than 25 kcal/kgIBW had a median survival of 24 months, increasing to 38 months for those consuming between 25–30 kcal/kgIBW and 63 months for those consuming 30 kcal/kgIBW or more. Deviations from the TEE did not significantly affect survival (p = 0.36). Among patients consuming less than their TEE, those consuming less than 25 kcal/kgIBW had a shorter median survival (24 months) compared to their counterparts (46 months) (p = 0.022). Consumption of less than 25 kcal/kgBW emerged as a significant negative predictor of patient outcome, independent of factors such as age, gender or disease progression.DiscussionIntakes of 25 kcal/kgIBW or more are correlated with improved ALS outcomes, and larger, multi-regional studies are recommended for deeper insights. |
| first_indexed | 2024-03-11T11:44:38Z |
| format | Article |
| id | doaj.art-72b3448007d34a04bf3ab7ea3ff39f6a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T11:44:38Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-72b3448007d34a04bf3ab7ea3ff39f6a2023-11-09T15:26:56ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-11-011410.3389/fneur.2023.12861531286153Ideal body weight-based determination of minimum oral calories beneficial to function and survival in ALSRyutaro Nakamura0Mika Kurihara1Shuhei Kobashi2Yoshitaka Tamaki3Nobuhiro Ogawa4Akihiro Kitamura5Isamu Yamakawa6Shigeki Bamba7Shigeki Bamba8Tomoya Terashima9Makoto Urushitani10Department of Neurology, Shiga University of Medical Science, Otsu, JapanDivision of Clinical Nutrition, Shiga University of Medical Science, Otsu, JapanDepartment of Neurology, Shiga University of Medical Science, Otsu, JapanDepartment of Neurology, Shiga University of Medical Science, Otsu, JapanDepartment of Neurology, Shiga University of Medical Science, Otsu, JapanDepartment of Neurology, Shiga University of Medical Science, Otsu, JapanDepartment of Neurology, Shiga University of Medical Science, Otsu, JapanDivision of Clinical Nutrition, Shiga University of Medical Science, Otsu, JapanDepartment of Fundamental Nursing, Shiga University of Medical Science, Otsu, JapanDepartment of Neurology, Shiga University of Medical Science, Otsu, JapanDepartment of Neurology, Shiga University of Medical Science, Otsu, JapanIntroductionThis study sought to identify the optimal caloric intake to improve function and survival in ALS patients by comparing oral intake per ideal body weight (IBW) and its discrepancy with total energy expenditure (TEE) using the Shimizu formula.MethodsA retrospective analysis of 104 ALS patients was conducted, categorizing them based on their average intake during the first week after admission using two primary intake cutoffs: 25 kcal/kgIBW and 30 kcal/kgIBW. The variance between oral intake and TEE was also evaluated using −300 kcal and 0 kcal as reference points.ResultsOral caloric intake per IBW and functional decline rate (rs = −0.35, p < 0.001), but the variance from TEE was not significantly correlated (−0.11, p = 0.27). Survival data showed that patients consuming less than 25 kcal/kgIBW had a median survival of 24 months, increasing to 38 months for those consuming between 25–30 kcal/kgIBW and 63 months for those consuming 30 kcal/kgIBW or more. Deviations from the TEE did not significantly affect survival (p = 0.36). Among patients consuming less than their TEE, those consuming less than 25 kcal/kgIBW had a shorter median survival (24 months) compared to their counterparts (46 months) (p = 0.022). Consumption of less than 25 kcal/kgBW emerged as a significant negative predictor of patient outcome, independent of factors such as age, gender or disease progression.DiscussionIntakes of 25 kcal/kgIBW or more are correlated with improved ALS outcomes, and larger, multi-regional studies are recommended for deeper insights.https://www.frontiersin.org/articles/10.3389/fneur.2023.1286153/fullamyotrophic lateral sclerosisnutritional therapyideal body weightmetabolismprognosis |
| spellingShingle | Ryutaro Nakamura Mika Kurihara Shuhei Kobashi Yoshitaka Tamaki Nobuhiro Ogawa Akihiro Kitamura Isamu Yamakawa Shigeki Bamba Shigeki Bamba Tomoya Terashima Makoto Urushitani Ideal body weight-based determination of minimum oral calories beneficial to function and survival in ALS Frontiers in Neurology amyotrophic lateral sclerosis nutritional therapy ideal body weight metabolism prognosis |
| title | Ideal body weight-based determination of minimum oral calories beneficial to function and survival in ALS |
| title_full | Ideal body weight-based determination of minimum oral calories beneficial to function and survival in ALS |
| title_fullStr | Ideal body weight-based determination of minimum oral calories beneficial to function and survival in ALS |
| title_full_unstemmed | Ideal body weight-based determination of minimum oral calories beneficial to function and survival in ALS |
| title_short | Ideal body weight-based determination of minimum oral calories beneficial to function and survival in ALS |
| title_sort | ideal body weight based determination of minimum oral calories beneficial to function and survival in als |
| topic | amyotrophic lateral sclerosis nutritional therapy ideal body weight metabolism prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1286153/full |
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