Epigenetics and Vascular Senescence–Potential New Therapeutic Targets?
Epigenetics is defined as the heritable alterations of gene expression without changes to the coding sequence of DNA. These alterations are mediated by processes including DNA methylation, histone modifications, and non-coding RNAs mechanisms. Vascular aging consists of both structural and functiona...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.535395/full |
| _version_ | 1819076087453319168 |
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| author | Qian Ding Qian Ding Chunhong Shao Peter Rose Yi Zhun Zhu |
| author_facet | Qian Ding Qian Ding Chunhong Shao Peter Rose Yi Zhun Zhu |
| author_sort | Qian Ding |
| collection | DOAJ |
| description | Epigenetics is defined as the heritable alterations of gene expression without changes to the coding sequence of DNA. These alterations are mediated by processes including DNA methylation, histone modifications, and non-coding RNAs mechanisms. Vascular aging consists of both structural and functional changes in the vasculature including pathological processes that drive progression such as vascular cell senescence, inflammation, oxidation stress, and calcification. As humans age, these pathological conditions gradually accumulate, driven by epigenetic alterations, and are linked to various aging-related diseases. The development of drugs targeting a spectrum of epigenetic processes therefore offers novel treatment strategies for the targeting of age-related diseases. In our previous studies, we identified HDAC4, JMJD3, Fra-1, and GATA4 as potential pharmacological targets for regulating vascular inflammation, injury, and senescence. |
| first_indexed | 2024-12-21T18:35:44Z |
| format | Article |
| id | doaj.art-72b48235d1dd426ebf8fcfc9088af94b |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-21T18:35:44Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-72b48235d1dd426ebf8fcfc9088af94b2022-12-21T18:54:09ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-09-011110.3389/fphar.2020.535395535395Epigenetics and Vascular Senescence–Potential New Therapeutic Targets?Qian Ding0Qian Ding1Chunhong Shao2Peter Rose3Yi Zhun Zhu4State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, ChinaSchool of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaDepartment of Psychiatry, Huashan Hospital, Fudan University, Shanghai, ChinaSchool of Biosciences, University of Nottingham, Loughborough, United KingdomState Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, ChinaEpigenetics is defined as the heritable alterations of gene expression without changes to the coding sequence of DNA. These alterations are mediated by processes including DNA methylation, histone modifications, and non-coding RNAs mechanisms. Vascular aging consists of both structural and functional changes in the vasculature including pathological processes that drive progression such as vascular cell senescence, inflammation, oxidation stress, and calcification. As humans age, these pathological conditions gradually accumulate, driven by epigenetic alterations, and are linked to various aging-related diseases. The development of drugs targeting a spectrum of epigenetic processes therefore offers novel treatment strategies for the targeting of age-related diseases. In our previous studies, we identified HDAC4, JMJD3, Fra-1, and GATA4 as potential pharmacological targets for regulating vascular inflammation, injury, and senescence.https://www.frontiersin.org/article/10.3389/fphar.2020.535395/fullvascular agingepigeneticscell senescenceinflammationoxidation stresscalcification |
| spellingShingle | Qian Ding Qian Ding Chunhong Shao Peter Rose Yi Zhun Zhu Epigenetics and Vascular Senescence–Potential New Therapeutic Targets? Frontiers in Pharmacology vascular aging epigenetics cell senescence inflammation oxidation stress calcification |
| title | Epigenetics and Vascular Senescence–Potential New Therapeutic Targets? |
| title_full | Epigenetics and Vascular Senescence–Potential New Therapeutic Targets? |
| title_fullStr | Epigenetics and Vascular Senescence–Potential New Therapeutic Targets? |
| title_full_unstemmed | Epigenetics and Vascular Senescence–Potential New Therapeutic Targets? |
| title_short | Epigenetics and Vascular Senescence–Potential New Therapeutic Targets? |
| title_sort | epigenetics and vascular senescence potential new therapeutic targets |
| topic | vascular aging epigenetics cell senescence inflammation oxidation stress calcification |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.535395/full |
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