Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma
Abstract The purpose of this study was to ascertain whether a correlation exists between glaucoma-associated alteration of ocular vascular haemodynamics and endothelin-1 (ET-1) levels exist. Eyes of patients with cataract (n = 30) or glaucoma (n = 68) were examined with optical coherence tomography...
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| Format: | Article |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15401-5 |
| _version_ | 1811293704366850048 |
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| author | Claudia Lommatzsch Kai Rothaus Lasse Schopmeyer Maria Feldmann Dirk Bauer Swaantje Grisanti Carsten Heinz Maren Kasper |
| author_facet | Claudia Lommatzsch Kai Rothaus Lasse Schopmeyer Maria Feldmann Dirk Bauer Swaantje Grisanti Carsten Heinz Maren Kasper |
| author_sort | Claudia Lommatzsch |
| collection | DOAJ |
| description | Abstract The purpose of this study was to ascertain whether a correlation exists between glaucoma-associated alteration of ocular vascular haemodynamics and endothelin-1 (ET-1) levels exist. Eyes of patients with cataract (n = 30) or glaucoma (n = 68) were examined with optical coherence tomography (OCT) and OCT-angiography (OCT-A; AngioVue™-RTVue-XR; Optovue, Fremont, California, USA). The peripapillary and the macular vessel density (VD) values were measured. Inferior and superior retinal nerve fibre layer (RNFL) thickness loss was used for further OCT staging. Aqueous humour of the examined eye and plasma were sampled during cataract or glaucoma surgery and analysed by means of ELISA to determine their ET-1 level. Glaucoma eyes are characterised by reductions in RNFL thickness and VD that correlate significantly with the OCT GSS score. Peripheral and ocular ET-1 level were significantly elevated in patients with glaucoma and correlate positively with the OCT-GSS score of the entire study population. Peripapillary and macula VD of glaucoma patients correlates negatively with plasma ET-1 levels. Multivariable analysis showed a subordinate role of intraocular pressure predictive factor for impaired retinal blood flow compared with plasma ET-1 level in glaucoma. Peripheral ET-1 level serves as risk factor for detection of ocular blood flow changes in the optic nerve head region of glaucomatous eyes. |
| first_indexed | 2024-04-13T05:05:27Z |
| format | Article |
| id | doaj.art-72b4e7513fc14e6581bf8e714dfa7cc9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T05:05:27Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-72b4e7513fc14e6581bf8e714dfa7cc92022-12-22T03:01:11ZengNature PortfolioScientific Reports2045-23222022-07-0112111210.1038/s41598-022-15401-5Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucomaClaudia Lommatzsch0Kai Rothaus1Lasse Schopmeyer2Maria Feldmann3Dirk Bauer4Swaantje Grisanti5Carsten Heinz6Maren Kasper7Department of Ophthalmology and Ophtha Lab at St. Franziskus HospitalDepartment of Ophthalmology and Ophtha Lab at St. Franziskus HospitalAmsterdam UMC, Location AMCDepartment of Ophthalmology, Braunschweig HospitalDepartment of Ophthalmology and Ophtha Lab at St. Franziskus HospitalDepartment of Ophthalmology, University of LuebeckDepartment of Ophthalmology and Ophtha Lab at St. Franziskus HospitalDepartment of Ophthalmology and Ophtha Lab at St. Franziskus HospitalAbstract The purpose of this study was to ascertain whether a correlation exists between glaucoma-associated alteration of ocular vascular haemodynamics and endothelin-1 (ET-1) levels exist. Eyes of patients with cataract (n = 30) or glaucoma (n = 68) were examined with optical coherence tomography (OCT) and OCT-angiography (OCT-A; AngioVue™-RTVue-XR; Optovue, Fremont, California, USA). The peripapillary and the macular vessel density (VD) values were measured. Inferior and superior retinal nerve fibre layer (RNFL) thickness loss was used for further OCT staging. Aqueous humour of the examined eye and plasma were sampled during cataract or glaucoma surgery and analysed by means of ELISA to determine their ET-1 level. Glaucoma eyes are characterised by reductions in RNFL thickness and VD that correlate significantly with the OCT GSS score. Peripheral and ocular ET-1 level were significantly elevated in patients with glaucoma and correlate positively with the OCT-GSS score of the entire study population. Peripapillary and macula VD of glaucoma patients correlates negatively with plasma ET-1 levels. Multivariable analysis showed a subordinate role of intraocular pressure predictive factor for impaired retinal blood flow compared with plasma ET-1 level in glaucoma. Peripheral ET-1 level serves as risk factor for detection of ocular blood flow changes in the optic nerve head region of glaucomatous eyes.https://doi.org/10.1038/s41598-022-15401-5 |
| spellingShingle | Claudia Lommatzsch Kai Rothaus Lasse Schopmeyer Maria Feldmann Dirk Bauer Swaantje Grisanti Carsten Heinz Maren Kasper Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma Scientific Reports |
| title | Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
| title_full | Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
| title_fullStr | Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
| title_full_unstemmed | Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
| title_short | Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
| title_sort | elevated endothelin 1 levels as risk factor for an impaired ocular blood flow measured by oct a in glaucoma |
| url | https://doi.org/10.1038/s41598-022-15401-5 |
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