RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
RAF family kinases transmit signals from activated RAS at the plasma membrane to downstream kinases to control cell proliferation, differentiation and survival. Here the authors shed light on the molecular mechanisms whereby small molecule RAF inhibitors induce RAS-RAF association and paradoxical RA...
| Главные авторы: | , , , , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
Nature Portfolio
2017-10-01
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| Серии: | Nature Communications |
| Online-ссылка: | https://doi.org/10.1038/s41467-017-01274-0 |