The cellular basis of platelet secretion: Emerging structure/function relationships
Platelet activation has long been known to be accompanied by secretion from at least three types of compartments. These include dense granules, the major source of small molecules; α-granules, the major protein storage organelle; and lysosomes, the site of acid hydrolase storage. Despite ~60 years o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-02-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2016.1257786 |
| _version_ | 1797684270300397568 |
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| author | Shilpi Yadav Brian Storrie |
| author_facet | Shilpi Yadav Brian Storrie |
| author_sort | Shilpi Yadav |
| collection | DOAJ |
| description | Platelet activation has long been known to be accompanied by secretion from at least three types of compartments. These include dense granules, the major source of small molecules; α-granules, the major protein storage organelle; and lysosomes, the site of acid hydrolase storage. Despite ~60 years of research, there are still many unanswered questions about the cell biology of platelet secretion: for example, how are these secretory organelles organized to support cargo release and what are the key routes of cargo release, granule to plasma membrane or granule to canalicular system. Moreover, in recent years, increasing evidence points to the platelet being organized for secretion of the contents from other organelles, namely the dense tubular system (endoplasmic reticulum) and the Golgi apparatus. Conceivably, protein secretion is a widespread property of the platelet and its organelles. In this review, we concentrate on the cell biology of the α-granule and its structure/function relationships. We both review the literature and discuss the wide array of 3-dimensional, high-resolution structural approaches that have emerged in the last few years. These have begun to reveal new and unanticipated outcomes and some of these are discussed. We are hopeful that the next several years will bring rapid advances to this field that will resolve past controversies and be clinically relevant. |
| first_indexed | 2024-03-12T00:28:10Z |
| format | Article |
| id | doaj.art-72b891a721ff4d6c885f9b44ab876e9d |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:28:10Z |
| publishDate | 2017-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-72b891a721ff4d6c885f9b44ab876e9d2023-09-15T10:31:57ZengTaylor & Francis GroupPlatelets0953-71041369-16352017-02-0128210811810.1080/09537104.2016.12577861257786The cellular basis of platelet secretion: Emerging structure/function relationshipsShilpi Yadav0Brian Storrie1University of Arkansas for Medical SciencesUniversity of Arkansas for Medical SciencesPlatelet activation has long been known to be accompanied by secretion from at least three types of compartments. These include dense granules, the major source of small molecules; α-granules, the major protein storage organelle; and lysosomes, the site of acid hydrolase storage. Despite ~60 years of research, there are still many unanswered questions about the cell biology of platelet secretion: for example, how are these secretory organelles organized to support cargo release and what are the key routes of cargo release, granule to plasma membrane or granule to canalicular system. Moreover, in recent years, increasing evidence points to the platelet being organized for secretion of the contents from other organelles, namely the dense tubular system (endoplasmic reticulum) and the Golgi apparatus. Conceivably, protein secretion is a widespread property of the platelet and its organelles. In this review, we concentrate on the cell biology of the α-granule and its structure/function relationships. We both review the literature and discuss the wide array of 3-dimensional, high-resolution structural approaches that have emerged in the last few years. These have begun to reveal new and unanticipated outcomes and some of these are discussed. We are hopeful that the next several years will bring rapid advances to this field that will resolve past controversies and be clinically relevant.http://dx.doi.org/10.1080/09537104.2016.1257786alpha-granulesmicroscopyplatelets, platelet release reactionsecretion |
| spellingShingle | Shilpi Yadav Brian Storrie The cellular basis of platelet secretion: Emerging structure/function relationships Platelets alpha-granules microscopy platelets, platelet release reaction secretion |
| title | The cellular basis of platelet secretion: Emerging structure/function relationships |
| title_full | The cellular basis of platelet secretion: Emerging structure/function relationships |
| title_fullStr | The cellular basis of platelet secretion: Emerging structure/function relationships |
| title_full_unstemmed | The cellular basis of platelet secretion: Emerging structure/function relationships |
| title_short | The cellular basis of platelet secretion: Emerging structure/function relationships |
| title_sort | cellular basis of platelet secretion emerging structure function relationships |
| topic | alpha-granules microscopy platelets, platelet release reaction secretion |
| url | http://dx.doi.org/10.1080/09537104.2016.1257786 |
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