Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis
<p>Abstract</p> <p>Background</p> <p>Little is known at the molecular level concerning the differences and/or similarities between alcohol and hepatitis C virus induced liver disease. Global transcriptional profiling using oligonucleotide microarrays was therefore perfo...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-11-01
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| Series: | Virology Journal |
| Online Access: | http://www.virologyj.com/content/3/1/98 |
| _version_ | 1818567080696348672 |
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| author | Boix Loreto Robinzon Shahar Paeper Bryan Proll Sean Walters Kathie-Anne Lederer Sharon L Fausto Nelson Bruix Jordi Katze Michael G |
| author_facet | Boix Loreto Robinzon Shahar Paeper Bryan Proll Sean Walters Kathie-Anne Lederer Sharon L Fausto Nelson Bruix Jordi Katze Michael G |
| author_sort | Boix Loreto |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Little is known at the molecular level concerning the differences and/or similarities between alcohol and hepatitis C virus induced liver disease. Global transcriptional profiling using oligonucleotide microarrays was therefore performed on liver biopsies from patients with cirrhosis caused by either chronic alcohol consumption or chronic hepatitis C virus (HCV).</p> <p>Results</p> <p>Global gene expression patterns varied significantly depending upon etiology of liver disease, with a greater number of differentially regulated genes seen in HCV-infected patients. Many of the gene expression changes specifically observed in HCV-infected cirrhotic livers were expectedly associated with activation of the innate antiviral immune response. We also compared severity (CTP class) of cirrhosis for each etiology and identified gene expression patterns that differentiated ethanol-induced cirrhosis by class. CTP class A ethanol-cirrhotic livers showed unique expression patterns for genes implicated in the inflammatory response, including those related to macrophage activation and migration, as well as lipid metabolism and oxidative stress genes.</p> <p>Conclusion</p> <p>Stages of liver cirrhosis could be differentiated based on gene expression patterns in ethanol-induced, but not HCV-induced, disease. In addition to genes specifically regulating the innate antiviral immune response, mechanisms responsible for differentiating chronic liver damage due to HCV or ethanol may be closely related to regulation of lipid metabolism and to effects of macrophage activation on deposition of extracellular matrix components.</p> |
| first_indexed | 2024-12-14T06:18:52Z |
| format | Article |
| id | doaj.art-72b8f18bf1174557904a51544dba78f2 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-14T06:18:52Z |
| publishDate | 2006-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-72b8f18bf1174557904a51544dba78f22022-12-21T23:13:55ZengBMCVirology Journal1743-422X2006-11-01319810.1186/1743-422X-3-98Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosisBoix LoretoRobinzon ShaharPaeper BryanProll SeanWalters Kathie-AnneLederer Sharon LFausto NelsonBruix JordiKatze Michael G<p>Abstract</p> <p>Background</p> <p>Little is known at the molecular level concerning the differences and/or similarities between alcohol and hepatitis C virus induced liver disease. Global transcriptional profiling using oligonucleotide microarrays was therefore performed on liver biopsies from patients with cirrhosis caused by either chronic alcohol consumption or chronic hepatitis C virus (HCV).</p> <p>Results</p> <p>Global gene expression patterns varied significantly depending upon etiology of liver disease, with a greater number of differentially regulated genes seen in HCV-infected patients. Many of the gene expression changes specifically observed in HCV-infected cirrhotic livers were expectedly associated with activation of the innate antiviral immune response. We also compared severity (CTP class) of cirrhosis for each etiology and identified gene expression patterns that differentiated ethanol-induced cirrhosis by class. CTP class A ethanol-cirrhotic livers showed unique expression patterns for genes implicated in the inflammatory response, including those related to macrophage activation and migration, as well as lipid metabolism and oxidative stress genes.</p> <p>Conclusion</p> <p>Stages of liver cirrhosis could be differentiated based on gene expression patterns in ethanol-induced, but not HCV-induced, disease. In addition to genes specifically regulating the innate antiviral immune response, mechanisms responsible for differentiating chronic liver damage due to HCV or ethanol may be closely related to regulation of lipid metabolism and to effects of macrophage activation on deposition of extracellular matrix components.</p>http://www.virologyj.com/content/3/1/98 |
| spellingShingle | Boix Loreto Robinzon Shahar Paeper Bryan Proll Sean Walters Kathie-Anne Lederer Sharon L Fausto Nelson Bruix Jordi Katze Michael G Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis Virology Journal |
| title | Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis |
| title_full | Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis |
| title_fullStr | Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis |
| title_full_unstemmed | Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis |
| title_short | Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis |
| title_sort | distinct cellular responses differentiating alcohol and hepatitis c virus induced liver cirrhosis |
| url | http://www.virologyj.com/content/3/1/98 |
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