COMPARATIVE EVALUATION OF THE EFFICIENCY OF BASIC DRUGS IN THE TREATMENT OF CHILDREN AND ADOLESCENTS WITH DIFFERENT TYPES OF JUVENILE IDIOPATHIC ARTHRITIS
Objective. To specify the diagnosis of juvenile idiopathic arthritis (JIA) and to define the significance of pathogenetic changes, the authors have studied cellular and humoral immunological parameters, which are of the greatest informative value in this pathology: CD4+, CD4+/CD8+, CD8+, CD16+, CD95...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2009-12-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/258 |
| _version_ | 1797876835029090304 |
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| author | Vladimir Alekseyevich Keltsev L I Grebenkina O R Bukhareva M A Bochkareva Yu E Grigoryeva Yu Yu Antonova |
| author_facet | Vladimir Alekseyevich Keltsev L I Grebenkina O R Bukhareva M A Bochkareva Yu E Grigoryeva Yu Yu Antonova |
| author_sort | Vladimir Alekseyevich Keltsev |
| collection | DOAJ |
| description | Objective. To specify the diagnosis of juvenile idiopathic arthritis (JIA) and to define the significance of pathogenetic changes, the authors have studied cellular and humoral immunological parameters, which are of the greatest informative value in this pathology: CD4+, CD4+/CD8+, CD8+, CD16+, CD95+ in the serum, as well as a spectrum of interleukins (IL): tumor necrosis factor-а, IL-6, IL-1, and IL-4. Subjects and methods. An optimal basic drug was selected for a specific form of JIA. Preference is given to cyclosporine and methorexate (MT) in its polyarticular form with the high activity of an inflammatory process, to MT, cyclosporine A, and auranofin in the disseminated form of oligoarthritis, and to auranofin and sulfasalazine in the persistent form. Results. None of the basic drugs is superior while individually choosing a treatment and this or that drug has to be very frequently chosen empirically |
| first_indexed | 2024-04-10T02:08:50Z |
| format | Article |
| id | doaj.art-72baa6f5fc4f48968e8a4b56fdb83122 |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:08:50Z |
| publishDate | 2009-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-72baa6f5fc4f48968e8a4b56fdb831222023-03-13T08:39:21ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2009-12-0134475310.14412/1996-7012-2009-5731563COMPARATIVE EVALUATION OF THE EFFICIENCY OF BASIC DRUGS IN THE TREATMENT OF CHILDREN AND ADOLESCENTS WITH DIFFERENT TYPES OF JUVENILE IDIOPATHIC ARTHRITISVladimir Alekseyevich KeltsevL I GrebenkinaO R BukharevaM A BochkarevaYu E GrigoryevaYu Yu AntonovaObjective. To specify the diagnosis of juvenile idiopathic arthritis (JIA) and to define the significance of pathogenetic changes, the authors have studied cellular and humoral immunological parameters, which are of the greatest informative value in this pathology: CD4+, CD4+/CD8+, CD8+, CD16+, CD95+ in the serum, as well as a spectrum of interleukins (IL): tumor necrosis factor-а, IL-6, IL-1, and IL-4. Subjects and methods. An optimal basic drug was selected for a specific form of JIA. Preference is given to cyclosporine and methorexate (MT) in its polyarticular form with the high activity of an inflammatory process, to MT, cyclosporine A, and auranofin in the disseminated form of oligoarthritis, and to auranofin and sulfasalazine in the persistent form. Results. None of the basic drugs is superior while individually choosing a treatment and this or that drug has to be very frequently chosen empiricallyhttps://mrj.ima-press.net/mrj/article/view/258ювенильный идиопатический артритподростки и детииммунный статусбазисные препараты |
| spellingShingle | Vladimir Alekseyevich Keltsev L I Grebenkina O R Bukhareva M A Bochkareva Yu E Grigoryeva Yu Yu Antonova COMPARATIVE EVALUATION OF THE EFFICIENCY OF BASIC DRUGS IN THE TREATMENT OF CHILDREN AND ADOLESCENTS WITH DIFFERENT TYPES OF JUVENILE IDIOPATHIC ARTHRITIS Современная ревматология ювенильный идиопатический артрит подростки и дети иммунный статус базисные препараты |
| title | COMPARATIVE EVALUATION OF THE EFFICIENCY OF BASIC DRUGS IN THE TREATMENT OF CHILDREN AND ADOLESCENTS WITH DIFFERENT TYPES OF JUVENILE IDIOPATHIC ARTHRITIS |
| title_full | COMPARATIVE EVALUATION OF THE EFFICIENCY OF BASIC DRUGS IN THE TREATMENT OF CHILDREN AND ADOLESCENTS WITH DIFFERENT TYPES OF JUVENILE IDIOPATHIC ARTHRITIS |
| title_fullStr | COMPARATIVE EVALUATION OF THE EFFICIENCY OF BASIC DRUGS IN THE TREATMENT OF CHILDREN AND ADOLESCENTS WITH DIFFERENT TYPES OF JUVENILE IDIOPATHIC ARTHRITIS |
| title_full_unstemmed | COMPARATIVE EVALUATION OF THE EFFICIENCY OF BASIC DRUGS IN THE TREATMENT OF CHILDREN AND ADOLESCENTS WITH DIFFERENT TYPES OF JUVENILE IDIOPATHIC ARTHRITIS |
| title_short | COMPARATIVE EVALUATION OF THE EFFICIENCY OF BASIC DRUGS IN THE TREATMENT OF CHILDREN AND ADOLESCENTS WITH DIFFERENT TYPES OF JUVENILE IDIOPATHIC ARTHRITIS |
| title_sort | comparative evaluation of the efficiency of basic drugs in the treatment of children and adolescents with different types of juvenile idiopathic arthritis |
| topic | ювенильный идиопатический артрит подростки и дети иммунный статус базисные препараты |
| url | https://mrj.ima-press.net/mrj/article/view/258 |
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